The waiting area in dental clinics is a known source of stress for patients. However, positive distractions and comfortable design elements might reduce stress levels and provide mental stimulation while awaiting treatment. While ambient elements might play an important role in patient well-being, few studies have directly explored the impact of various design attributes of dental clinic waiting areas on patients’ perceived stress. This study intended to bridge that gap and employed a discrete choice experiment method where 250 participants randomly selected a block and evaluated six pairs of computer-generated images of dental clinic waiting areas created based on eight interior design attributes with various levels: ambient lighting, false ceiling, window size, window view, indoor plants, wall shape, wall material, and seating options. Each visitor chose their preferred option in relation to its presumed effect on stress mitigation. The results suggest that the presence of ambient lighting, a false ceiling with a nature design, large window dimensions, a nature window view, green indoor plants, a curved wall shape, natural wall materials, and mixed seating options all can contribute to mitigating patients’ perceived stress. Additionally, our findings indicate that age, gender, and education might influence choices across some levels of these variables. Overall, these results might assist architects and designers in shaping clinic environments mitigating patient stress during visits. Further studies would be needed to validate our findings and should also consider additional design attributes, more immersive stimuli presentation technologies, as well as potential differences across cultural contexts.