The impact of infection control upon hospital-acquired influenza and respiratory syncytial virus

Weedon, Kathryn M.; Rupp, Angela; Heffron, Annie C.; Kelly, Sinead Forkan; Zheng, Xiaotian; Shulman, Stanford T.; Gutman, Peggy; Wang, Deli; Zhou, Ying; Noskin, Gary A.; Anderson, Evan J.

doi:10.3109/00365548.2012.726738

Cited by 16 publications

(22 citation statements)

References 32 publications

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“…All these elements provide additional evidence that these infections could be classified as healthcare-associated infections. Similarly, to what is observed for influenza viruses, parainfluenza virus type 3 and respiratory syncytial virus, our data show that HCoV−OC43 is involved in healthcare-associated infections [33][34][35].…”

Section: Discussionsupporting

confidence: 87%

Use of whole-genome sequencing in the molecular investigation of care-associated HCoV-OC43 infections in a hematopoietic stem cell transplant unit

Beury

Fléchon

Maurier

et al. 2020

Journal of Clinical Virology

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A B S T R A C TBackground: While respiratory viral infections are recognized as a frequent cause of illness in hematopoietic stem cell transplantation (HSCT) recipients, HCoV−OC43 infections have rarely been investigated as healthcareassociated infections in this population. Objectives: In this report, HCoV−OC43 isolates collected from HSCT patients were retrospectively characterized to identify potential clusters of infection that may stand for a hospital transmission. Study design: Whole-genome and S gene sequences were obtained from nasal swabs using next-generation sequencing and phylogenetic trees were constructed. Similar identity matrix and determination of the most common ancestor were used to compare clusters of patient's sequences. Amino acids substitutions were analysed. Results: Genotypes B, E, F and G were identified. Two clusters of patients were defined from chronological data and phylogenetic trees. Analyses of amino acids substitutions of the S protein sequences identified substitutions specific for genotype F strains circulating among European people. Conclusions: HCoV−OC43 may be implicated in healthcare-associated infections.

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Section: Discussionsupporting

confidence: 87%

Use of whole-genome sequencing in the molecular investigation of care-associated HCoV-OC43 infections in a hematopoietic stem cell transplant unit

Beury

Fléchon

Maurier

et al. 2020

Journal of Clinical Virology

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“…Incidence was expressed as HA-VRI incidence density (number of HA VRIs per 1000 patient-days) and VRI transmission index (number of HA VRIs per 100 inpatient CA VRIs). Because seasonal CA-VRI incidence varies substantially between VRPP and non-VRPP periods, and because HA-VRI transmission depends on inpatient CA-VRI burden, we normalized HA-VRI incidence to CA-VRI burden by calculating the VRI transmission index, as previously described [4]. Hand hygiene and personal protective equipment compliance, which were monitored monthly by direct observation in all inpatient units throughout the study period, were also compared between the VRPP and non-VRPP periods.…”

Section: Methodsmentioning

confidence: 99%

Association Between Children’s Hospital Visitor Restrictions and Healthcare-Associated Viral Respiratory Infections: A Quasi-Experimental Study

Forkpa

Rupp

Shulman

et al. 2019

Journal of the Pediatric Infectious Diseases Society

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We investigated the effect of annual winter visitor restrictions on hospital respiratory virus transmission. The healthcareassociated (HA) viral respiratory infection (VRI) transmission index (number of HA VRIs per 100 inpatient communityassociated VRIs) was 59% lower during the months in which visitor restrictions were implemented. These data prompt consideration for instituting year-round visitor restrictions.

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“…52 Staying away from situations that favor clusters of people during periods of increased viral circulation has been recommended, although there are no studies that proved the effectiveness of this strategy. 52,53 The use of substances such as herbal preparations including Echinacea and vitamin C has been evaluated, but double-blind, placebo-controlled studies failed to demonstrate their benefit. 54 The prevention of viral infections through vaccines has been the most effective way to control diseases caused by viruses.…”

Section: Preventive and Therapeutic Aspectsmentioning

confidence: 99%

Exacerbation of asthma and airway infection: is the virus the villain?

Costa¹,

Costa²,

Camargos³

2014

Jornal de Pediatria (Versão em Português)

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Objective: To review the available literature on the association between acute viral respiratory tract infection and the onset of asthma exacerbations, identifying the most prevalent viruses, detection methods, as well as preventive and therapeutic aspects. Sources: A search was conducted in PubMed, Lilacs, and SciELO databases, between the years 2002 and 2013, using the following descriptors: asthma exacerbation, virus, child, and acute respiratory infection. Summary of the findings: A total of 42 original articles addressing the identification of respiratory viruses during episodes of asthma exacerbation were selected, mostly cross-sectional studies. There was a wide variation in the methodology of the assessed studies, particularly in relation to the children's age and methods of collection and viral detection. The results indicate that, in up to 92.2% of exacerbations, a viral agent was potentially the main triggering factor, and human rhinovirus was the most frequently identified factor. The pattern of viral circulation may have been responsible for the seasonality of exacerbations. The association between viral infections and allergic inflammation appears to be crucial for the clinical and functional uncontrolled asthma, but few studies have evaluated other triggering factors in association with viral infection.Conclusions: Respiratory viruses are present in the majority of asthmatic children during episodes of exacerbation. The involved physiopathological mechanisms are yet to be fully established, and the synergism between allergic inflammation and viral infection appears to determine uncontrolled disease. The role of other triggering and protective agents is yet to be clearly determined. ଝ Please cite this article as: Costa LD, Costa PS, Camargos PA. Exacerbation of asthma and airway infection: is the virus the villain? J Pediatr (Rio J). 2014;90:542---55. ଝଝ Study conducted at the Vírus; Criança; Infecção do trato respiratório Exacerbação da asma e infecção das vias aéreas: o vírus é o vilão?Resumo Objetivo: Rever a literatura disponível sobre a relação entre infecção viral aguda do trato respiratório e o desencadeamento de exacerbações da asma, identificando os vírus mais prevalentes, os métodos de detecção, bem como os aspectos preventivos e terapêuticos. Fonte dos dados: Foi realizada uma busca nas bases de dados PubMed, SciELO e Lilacs utilizando os descritores: asma, exacerbação, vírus, criança e infecção respiratória aguda, entre os anos de 2002 e 2013. Síntese dos dados: Foram selecionados 42 artigos originais que tratavam da identificação de vírus respiratórios durante episódios de exacerbação da asma, em sua maioria estudos transversais. Houve ampla variação na metodologia dos trabalhos avaliados, principalmente em relação à idade das crianças e métodos de coleta e detecção viral. Os resultados apontam que, em até 92,2% das exacerbações, um agente viral foi potencialmente o principal fator desencadeante, sendo o rinovírus humano o mais identificado. O padrão de circulação viral pode ter sido re...

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The impact of infection control upon hospital-acquired influenza and respiratory syncytial virus

Abstract: We observed that improvements in hand hygiene compliance correlated with less transmission of RSV and influenza in the hospital. The important role of hand hygiene in preventing transmission of RSV and influenza to hospitalized children should be emphasized.

Cited by 16 publications

References 32 publications

Use of whole-genome sequencing in the molecular investigation of care-associated HCoV-OC43 infections in a hematopoietic stem cell transplant unit

Use of whole-genome sequencing in the molecular investigation of care-associated HCoV-OC43 infections in a hematopoietic stem cell transplant unit

Association Between Children’s Hospital Visitor Restrictions and Healthcare-Associated Viral Respiratory Infections: A Quasi-Experimental Study

Exacerbation of asthma and airway infection: is the virus the villain?

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