The Impact of Inflammation on Cognitive Impairment in Chronic Kidney Disease Patients

Καλτσάτου, Αντωνία

doi:10.21767/2472-5056.100020

Cited by 6 publications

(3 citation statements)

References 68 publications

(87 reference statements)

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“…Cognitive impairment may also result from higher levels of inflammation, oxidative stress, anemia, and uremic toxins that rise with decreasing kidney function (McClellan et al, 2004;Oberg et al, 2004;Watanabe, Watanabe, & Nakayama, 2014). With inflammation in particular, increased levels of interleukin-6, interleukin-1β, fibrinogen, and C-reactive protein in CKD patients have been associated with increased cognitive impairment (Kalsatou, 2016;Kurella Tamura et al, 2017). There is also evidence that the parathyroid hormone is linked to greater cognitive deficits (Roman et al, 2011).…”

Section: Mechanisms Of Ckd-related Cognitive Impairmentmentioning

confidence: 99%

A Systematic Review of Cognitive Impairments Associated With Kidney Failure in Adults Before Natural Age-Related Changes

Brodski

Rossell

Castle

et al. 2018

J Int Neuropsychol Soc

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Objectives: Recognition of cognitive impairment in chronic kidney disease (CKD) and its impact on functioning in adults is growing. The vast majority of studies to date have been conducted in older populations where CKD is more pronounced; however, the degree to which age-related cognitive changes could be influencing these findings remains unaddressed. This current study thus aimed to review cognitive impairment findings by stage in non-elderly CKD samples. Methods: PubMed and Medline via Scopus were searched for cross-sectional or cohort studies and randomized controlled trials that assessed cognitive function in individuals with CKD in any research setting. CKD studies including patients at any illness stage were included providing participants were below 65 years old, were not on peritoneal dialysis and had not undergone a kidney transplant. Results: Fifteen studies, with a total of 9304 participants, were included. Cognitive function broadly deteriorated from stage 1 to stage 5. Early stage CKD was associated with a drop in speed of processing, attention, response speed, and short-term memory abilities. Moderate stage CKD was associated with deficits in executive functioning, verbal fluency, logical memory, orientation and concentration. People with end stage kidney disease manifested significant deficits in all previous cognitive domains, along with cognitive control, delayed and immediate memory, visuospatial impairment, and overall cognitive impairment. Conclusions: Cognitive impairment is evident across the stages of CKD, independent of age-related changes, for both lower-order and higher-order cognitive abilities. These impairments also increase between the stages, suggesting a cumulative effect. Future directions for research are discussed. (JINS, 2019, 25, 101–114)

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Section: Mechanisms Of Ckd-related Cognitive Impairmentmentioning

confidence: 99%

A Systematic Review of Cognitive Impairments Associated With Kidney Failure in Adults Before Natural Age-Related Changes

Brodski

Rossell

Castle

et al. 2018

J Int Neuropsychol Soc

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“…Additionally, there could even be a causal link between metabolic conditions and cognitive impairment—there are parallels for this finding in human medicine. Diabetes mellitus is associated with an amnestic mild cognitive impairment through vascular disease mechanisms [ 82 ], and chronic kidney disease is also associated with cognitive impairment due to altered cytokine production [ 83 ]. This latter mechanism relates back to inflammatory processes and highlights how interconnected the body systems are, meaning that they cannot be considered in isolation.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Signs of Medical Conditions and Cognitive Decline in Senior Dogs

Wrightson,

Albertini,

Pirrone

et al. 2023

Animals

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Canine cognitive dysfunction syndrome (CCDS) is a progressive age-related neurodegenerative disorder in dogs. Minimal research has been performed to investigate how clinical signs may be impacted by other medical conditions. A cross-sectional study was performed using the Canine Cognitive Assessment Scale (CCAS) to evaluate cognitive impairment as reported by owners. Owner-reported health-related measures included behaviour changes, the body condition score, and veterinary diagnoses of disease. The responses from 804 dogs in the last 25% of their expected lifespan were analysed. Factors were identified in the owner-reported behavioural signs of disease representing pathologies in four body systems: musculoskeletal–neurological, digestive, metabolic, and dermatological, with the items comprising these factors also compiled into a cumulative measure of health. The results showed a strong correlation between the CCAS score and both the musculoskeletal–neurological factor and the overall cumulative measure of health. Moderate correlations between the CCAS score and the digestive factor and metabolic factor were also observed. The correlation between the dermatological factor and the CCAS score was weak. This study highlights the need to screen dogs for concurrent diseases when using scales to assess cognitive impairment and to monitor dogs who have health conditions, particularly those that are painful, for the onset of cognitive impairment.

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“…The frequent occurrence of neurological complications in patients with CKD [ 1 , 29 ] and RTRs [ 2 ] justifies the need for further investigations into this relevant issue. Indeed, kidney-brain cross-talk has attracted interest from researchers in the last decade [ 30 – 32 ].…”

Section: Discussionmentioning

confidence: 99%

Transcranial sonography depicts a larger substantia nigra echogenic area in renal transplant patients on calcineurin inhibitors than on rapamycin

2022

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Background After kidney transplantation neurologic manifestations may develop, including Parkinson’s disease (PD). An enlarged substantia nigra (SN) by transcranial sonography has been recognized as a marker of PD. Methods In renal transplant recipients (RTRs = 95) and controls (n = 20), measurement of mesencephalon, SN, third ventricle, spleen and carotid intima-media thickness (cIMT) and middle cerebral artery (MCA), kidney and spleen arteries Doppler resistive index (RI) were performed. Results RTRs had larger SN, third ventricle and cIMT and higher renal RI than controls. The SN was larger in the CNIs group than in controls and rapamycin group, while the third ventricle was similar between patients but larger than in controls. In RTRs, SN showed a direct linear correlation with spleen and the third ventricle with age, cIMT and RI of the MCA, kidney and spleen. In CNIs group the SN correlated positively with age and cIMT, while the third ventricle reproduced RTRs correlations. Rapamycin group showed a direct linear relationship between the third ventricle and age and RI of the MCA, kidney and spleen; SN showed no correlations. Conclusion RTRs on CNIs present a larger SN area than on rapamycin, probably due to the antiproliferative effect of rapamycin. This finding might be relevant when interpreting TCS in RTRs.

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The Impact of Inflammation on Cognitive Impairment in Chronic Kidney Disease Patients

Cited by 6 publications

References 68 publications

A Systematic Review of Cognitive Impairments Associated With Kidney Failure in Adults Before Natural Age-Related Changes

A Systematic Review of Cognitive Impairments Associated With Kidney Failure in Adults Before Natural Age-Related Changes

The Relationship between Signs of Medical Conditions and Cognitive Decline in Senior Dogs

Transcranial sonography depicts a larger substantia nigra echogenic area in renal transplant patients on calcineurin inhibitors than on rapamycin

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