The impact of initial concentration of selected pharmaceuticals on their early stage of dissipation in soils

Menacherry, Sunil Paul M.; Kočárek, Martin; Kačerová, Tereza; Kotíková, Zora; Kačer, Petr; Kodešová, Radka

doi:10.1007/s11368-021-03095-7

Cited by 9 publications

(11 citation statements)

References 55 publications

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“…3). This fact clearly demonstrated the stability of this molecule within the soil environment as clearly noticed by previous researchers (Kodešová et al 2020;Menacherry et al 2022b). The results obtained after the simultaneous application of these pharmaceuticals are presented in a later section.…”

Section: Pharmaceuticals Remained In the Soilssupporting

confidence: 85%

“…Minor differences were also observed in the remaining concentration of pharmaceuticals in soil as well (Fig. 3B; please see Tables S15 for exact values), indicating either an enhancement in their accumulation (e.g., onion leaves) or their faster dissipation after applying them simultaneously as already noticed by various researchers (Khalaf et al 2022;Menacherry et al 2022b;Papaioannou et al 2019;Styrishave et al 2011;Zheng and Guo 2021). By considering the differences in the BAF calculations between the single and simultaneous application (which accounts the possible degradation of parent pharmaceuticals in the soil environment), such changes are well anticipated.…”

Section: Accumulation Of Pharmaceuticals In Plants After Simultaneous...supporting

confidence: 68%

“…Additionally, the stability of an individual pharmaceutical on a given soil type, which in-turn is associated with several factors, such as the soil-molecule interactions, efficiency of degradation pathways, and various other environmental factors (Diez 2010), is also expected to influence their uptake. By considering the established relationship between the speciation of pharmaceuticals (i.e., neutral, anionic, or cationic) on its dissipation within the soil compartments, it is expected that the molecule with higher stability and lower dissipation characteristics will be more susceptible to plant uptake and translocation through the transpiration stream (Diez 2010;Koba et al 2016;Kodešová et al 2015Kodešová et al , 2016Kodešová et al , 2020Menacherry et al 2022b). S16 and S17 Systematic studies on the transfer of pharmaceuticals existing in soils, either adsorbed on the soil solids or dissolved in the soil pore water, to plant are recently available (Christou et al 2019;Keerthanan et al 2021;Miller et al 2016;Zheng and Guo 2021).…”

Section: Discussionmentioning

confidence: 99%

“…During these studies, the six parent pharmaceuticals (CAR, CIT, CIL, FEX, IRB, SUL), either alone or as a mixture of all together, were applied on three selected plants (onion (Allium cepa L.), spinach (Spinacea oleracea L.), and radish (Raphanus sativus L.)) grown in small pots (volume: 340 cm 3 ) filled with one of the six selected soils taken from the surface horizons of the following soil types: Stagnic Chernozem Siltic (SChS), Haplic Chernozem (HCh), Greyic Phaeozem (GP), Haplic Luvisol (HL), Haplic Cambisol (HCa), Dystric Cambisol (DCa). All these soil types, either all or few of them, were recently utilized for the studies of Schmidtová et al (2020), Kodešová et al (2019aKodešová et al ( , b, 2020, Frková et al (2020), and other researchers (Brunetti et al 2021;Golovko et al 2016;Klement et al 2020;Menacherry et al 2022b). The physical properties of the fresh soil samples taken for this study (e.g., soil organic content, sand and clay proportions) as well as the sorption and dissipation behaviors of the selected parent pharmaceuticals on each of them were previously analyzed by Frková et al (2020), Kodešová et al (2020), andSchmidtová et al (2020).…”

Section: Pot Experimentsmentioning

confidence: 99%

“…Moreover, the above-described analytical method for soil analyses is already validated for a wide range of compounds (including CAR, CIT, CLI, FEX, IRB, SUL, and their metabolites) and soils (including the soils used in this study) (Brunetti et al 2021(Brunetti et al , 2022Golovko et al 2016;Kodešová et al 2020;Menacherry et al 2022b). The method used for the analysis of plant tissues is also validated for three leafy vegetables (arugula, spinach, and lamb's lettuce), radish (Kodešová et al 2019a, b), green pea (Klement et al 2020), spinach (Kodešová et al 2019a), and others (Brunetti et al 2021(Brunetti et al , 2022.…”

Section: Analysis Of Pharmaceuticals and Their Metabolites By Lc-ms/msmentioning

confidence: 99%

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Selective accumulation of pharmaceutical residues from 6 different soils by plants: a comparative study on onion, radish, and spinach

Menacherry

Kodešová

Švecová

et al. 2023

Environ Sci Pollut Res

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The accumulation of six pharmaceuticals of different therapeutic uses has been thoroughly investigated and compared between onion, spinach, and radish plants grown in six soil types. While neutral molecules (e.g., carbamazepine (CAR) and some of its metabolites) were efficiently accumulated and easily translocated to the plant leaves (onion > radish > spinach), the same for ionic (both anionic and cationic) molecules seems to be minor to moderate. The maximum accumulation of CAR crosses 38,000 (onion), 42,000 (radish), and 7000 (spinach) ng g−1 (dry weight) respectively, in which the most majority of them happened within the plant leaves. Among the metabolites, the accumulation of carbamazepine 10,11-epoxide (EPC — a primary CAR metabolite) was approximately 19,000 (onion), 7000 (radish), and 6000 (spinach) ng g−1 (dry weight) respectively. This trend was considerably similar even when all these pharmaceuticals applied together. The accumulation of most other molecules (e.g., citalopram, clindamycin, clindamycin sulfoxide, fexofenadine, irbesartan, and sulfamethoxazole) was restricted to plant roots, except for certain cases (e.g., clindamycin and clindamycin sulfoxide in onion leaves). Our results clearly demonstrated the potential role of this accumulation process on the entrance of pharmaceuticals/metabolites into the food chain, which eventually becomes a threat to associated living biota.

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Section: Pharmaceuticals Remained In the Soilssupporting

confidence: 85%

Section: Accumulation Of Pharmaceuticals In Plants After Simultaneous...supporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Pot Experimentsmentioning

confidence: 99%

Section: Analysis Of Pharmaceuticals and Their Metabolites By Lc-ms/msmentioning

confidence: 99%

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Selective accumulation of pharmaceutical residues from 6 different soils by plants: a comparative study on onion, radish, and spinach

Menacherry

Kodešová

Švecová

et al. 2023

Environ Sci Pollut Res

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Toxicity Risks Associated With the Beta‐Blocker Metoprolol in Marine and Freshwater Organisms: A Review

Love,

Slovisky,

Costa

et al. 2024

Enviro Toxic and Chemistry

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The detection of pharmaceuticals in aquatic ecosystems has generated concern for wildlife and human health over the past several decades. β‐adrenergic blocking agents are a class of drugs designed to treat cardiovascular diseases and high blood pressure. Metoprolol is a second‐generation β1‐adrenergic receptor inhibitor detected in effluent derived from sewage treatment plants. Our review presents an updated survey of the current state of knowledge regarding the sources, occurrence, and toxicity of metoprolol in aquatic ecosystems. We further aimed to summarize the current literature on the presence of metoprolol in various classes of aquatic species and to consider the trophic transfer of these contaminants in marine mammals. The biological impacts of metoprolol have been reported in 20 aquatic organisms, with a primary focus on cardiac function and oxidative stress. Our review reveals that concentrations of metoprolol that cause toxicity in aquatic species are above levels that are typical of marine and freshwater environments. Future studies should investigate the effects of metoprolol at lower concentrations in aquatic organisms. Other recommendations include (1) a further focus on noncardiac endpoints, because computational assessments of currently available molecular data identify gonadotropins, vitellogenin, collagen, and cytokines as potential targets of modulation, and (2) development of adverse outcome pathways for cardiac dysfunction in aquatic species to improve our understanding of molecular interactions and outcomes following exposure. As the next generation of β‐blockers is developed, continued diligence is needed for assessing environmental impacts in aquatic ecosystems to determine their potential accumulation and long‐term effects on wildlife and humans. Environ Toxicol Chem 2024;00:1–14. © 2024 SETAC

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Phytoremediation of pharmaceutical compounds in soil

N.,

Singh,

Khan

et al. 2024

Bioremediation of Emerging Contaminants From Soils

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The impact of initial concentration of selected pharmaceuticals on their early stage of dissipation in soils

Cited by 9 publications

References 55 publications

Selective accumulation of pharmaceutical residues from 6 different soils by plants: a comparative study on onion, radish, and spinach

Selective accumulation of pharmaceutical residues from 6 different soils by plants: a comparative study on onion, radish, and spinach

Toxicity Risks Associated With the Beta‐Blocker Metoprolol in Marine and Freshwater Organisms: A Review

Phytoremediation of pharmaceutical compounds in soil

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