@ERSpublications Self-management interventions in patients with COPD need to address the complexity of multimorbidity and should include action plans for worsening of both COPD and common comorbidities in order to empower patients to manage their different diseases. http://bit.ly/2nXSCuzCite this article as: Vanfleteren LEGW, Fabbri LM. Self-management interventions in COPD patients with multimorbidity. Eur Respir J 2019; 54: 1901850 [https://doi.org/10.1183/13993003.01850-2019.Self-management interventions in patients with COPD have the goals of motivating, engaging and supporting patients to positively adapt their behaviours and develop skills to better manage their disease. Exacerbation action plans are a key component of COPD self-management interventions [1,2], and self-management interventions are a key component of COPD management [3]. However, studies assessing these interventions show contradictory results, particularly depending on the primary outcome, e.g. quality of life, exacerbations, re-hospitalisations or mortality [1, 2, 4].Self-management interventions, including a COPD exacerbation action plan, are associated with improved health status, as measured by St George's Respiratory Questionnaire (SGRQ), and a lower probability of respiratory-related hospital admissions. Conflicting results on the incidence of exacerbation and mortality have been reported: Exploratory analyses showed a small but significantly higher respiratory-related mortality rate in patients with a high risk of exacerbation [2,5].COPD is almost invariably associated with concomitant chronic diseases, commonly termed comorbidities. A more proper term probably is multimorbidities, i.e. two or more diseases occurring in a person in whom it is difficult to identify an index disease [6]. Exacerbations of COPD should be evaluated in this context. A deterioration of respiratory symptoms in a multimorbid patient who also has COPD demands a differential diagnosis. Viral or bacterial infections, but also heart failure, coronary heart disease, pulmonary embolism and panic attacks, can be equated with an exacerbation of COPD [7].Thus, COPD is just the pulmonary component of multimorbidity, and consequently a patient with COPD should be managed comprehensively for all concomitant chronic diseases that can be identified [3,6,8]. However, a recent elegant and well-designed intervention aimed at comprehensively addressing the complexity of multimorbidity did not improve the quality of life of the patients studied [9].In this issue of the European Respiratory Journal, LENFERINK et al.[10] report the results of an international randomised controlled trial intended to evaluate whether COPD patients with multimorbidities who had been trained in using a patient-tailored multidisease exacerbation action plan (figure 1) had fewer days of COPD exacerbations. Unfortunately, the study was negative for the primary outcome (number of COPD exacerbation days per patient per year) but showed a significant reduction of some relevant predefined secondary outcomes...