The Impact of Interleukin (IL)-33 Gene Polymorphisms and Environmental Factors on Risk of Asthma in the Iranian Population

Matloubi, Mojdeh; Ranjbar, Maral; Assarehzadegan, Mohammad-Ali; Fallahpour, Morteza; Sadeghi, Fatemeh; Soleyman-Jahi, Saeed; Janani, Leila

doi:10.1007/s00408-019-00301-9

Cited by 11 publications

(6 citation statements)

References 27 publications

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“…A larger study conducted in Finland, including 521 cases of adult onset asthma and 1016 controls reported a direct association between SNPs rs996029, rs2006682, rs7037276, and adult onset asthma [ 23 ]. The same correlation has been demonstrated for the SNPs rs3939286 and rs1342326 [ 24 ].…”

Section: Genetic Polymorphisms Associated With Asthma Susceptibility ...supporting

confidence: 74%

The Genetic Factors of the Airway Epithelium Associated with the Pathology of Asthma

Ranjbar

Whetstone

Omer

et al. 2022

Genes

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Asthma is a chronic disease of the airways characterized by inflammation, tightened muscles, and thickened airway walls leading to symptoms such as shortness of breath, chest tightness, and cough in patients. The increased risk of asthma in children of asthmatics parents supports the existence of genetic factors involved in the pathogenesis of this disease. Genome-wide association studies have discovered several single nucleotide polymorphisms associated with asthma. These polymorphisms occur within several genes and can contribute to different asthma phenotypes, affect disease severity, and clinical response to different therapies. The complexity in the etiology of asthma also results from interactions between environmental and genetic factors. Environmental exposures have been shown to increase the prevalence of asthma in individuals who are genetically susceptible. This review summarizes what is currently known about the genetics of asthma in relation to risk, response to common treatments, and gene-environmental interactions.

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Section: Genetic Polymorphisms Associated With Asthma Susceptibility ...supporting

confidence: 74%

The Genetic Factors of the Airway Epithelium Associated with the Pathology of Asthma

Ranjbar

Whetstone

Omer

et al. 2022

Genes

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“…However, these results are not fully comparable with ours due to differences in the study population and age distribution and have not been replicated in other populations. In addition, other studies have identified SNPs in the IL18 receptor gene cluster and in the IL1 family that are linked to asthma-associated biomarkers (i.e., serum IgE, blood eosinophilic counts) in asthma or other allergic disorders [ 36 , 37 , 38 , 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

IL18 Gene Polymorphism Is Associated with Total IgE in Adult Subjects with Asthma

Lando

Calciano

Minelli

et al. 2023

JCM

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The allergic asthma phenotype is characterized by a T helper type 2 (Th2) immune response, based on Immunoglobulin E (IgE)-mediated type 1 hypersensitivity reactions. Total IgE is the sum of all IgE types produced by the human body and is used as a biomarker of inflammation in asthma. We analysed data collected in 143 asthma cases (median age 42.1 years) from the general Italian population (GEIRD survey; 2008–2010) to identify single nucleotide polymorphisms (SNPs) in candidate genes that are associated with total IgE in adult subjects with asthma. These patients reported respiratory symptoms in response to perennial allergens and provided data on 166 SNPs tagging 50 candidate genes or gene regions. Replication of the statistically significant results was performed in 842 asthma cases from other European countries (ECRHS II survey; 1998–2002). SNP rs549908 in interleukin 18 (IL18) gene was significantly associated with total IgE in GEIRD, and this result was replicated in ECRHS II. SNP rs1063320 in the human leukocyte antigen G (HLA-G) gene was identified in GEIRD, but this association was not replicated in ECRHS II. Further investigating IL18 and its biological pathways could be important for developing new therapeutic targets, due to its involvement in inflammatory response processes.

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“…Many of the SNPs in the IL-33 gene that have been studied in asthmatic patients have demonstrated a positive and direct association with asthma. Rs3939286, rs16924159, rs1342326, and rs992969 are among the SNPs that are more pronounced in the asthmatic population compared to the healthy subjects [ 231 , 233 , 234 ]. Reports on the associations of different variants show that the presence of only one mutated allele in the genome can result in a significant direct or inverse association.…”

Section: Variants Of Alarmins Genes In Asthmamentioning

confidence: 99%

The Role of Airway Epithelial Cell Alarmins in Asthma

Whetstone

Ranjbar

Omer

et al. 2022

Cells

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The airway epithelium is the first line of defense for the lungs, detecting inhaled environmental threats through pattern recognition receptors expressed transmembrane or intracellularly. Activation of pattern recognition receptors triggers the release of alarmin cytokines IL-25, IL-33, and TSLP. These alarmins are important mediators of inflammation, with receptors widely expressed in structural cells as well as innate and adaptive immune cells. Many of the key effector cells in the allergic cascade also produce alarmins, thereby contributing to the airways disease by driving downstream type 2 inflammatory processes. Randomized controlled clinical trials have demonstrated benefit when blockade of TSLP and IL-33 were added to standard of care medications, suggesting these are important new targets for treatment of asthma. With genome-wide association studies demonstrating associations between single-nucleotide polymorphisms of the TSLP and IL-33 gene and risk of asthma, it will be important to understand which subsets of asthma patients will benefit most from anti-alarmin therapy.

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The Impact of Interleukin (IL)-33 Gene Polymorphisms and Environmental Factors on Risk of Asthma in the Iranian Population

Cited by 11 publications

References 27 publications

The Genetic Factors of the Airway Epithelium Associated with the Pathology of Asthma

The Genetic Factors of the Airway Epithelium Associated with the Pathology of Asthma

IL18 Gene Polymorphism Is Associated with Total IgE in Adult Subjects with Asthma

The Role of Airway Epithelial Cell Alarmins in Asthma

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