The Impact of Intermittent Air Exposure on Lipid Deposition

Abstract

This study found that lipid deposition profiles are CL material dependent and that intermittent air exposure can influence the mass of lipid deposited.

Development of an <em>In Vitro</em> Ocular Platform to Test Contact Lenses

“…The limitations of the conventional vial model have been recognized by researchers, and attempts have been made to create unique in vitro eye models simulating the ocular environment, by including a microfluidic tear replenishment component [20][21][22][23][24] and/or intermittent air exposure. 25,26 Not surprisingly, the results generated from these experiments are very different than those obtained with the conventional vial model, and may more closely resemble in vivo data. [20][21][22][23][24][25] Thus, developing an intricate in vitro eye model to examine CLs will provide new insights on the interaction of lens materials with the ocular surface, and help facilitate the development of new materials and new applications for CLs in the coming decades.…”

“…25,26 Not surprisingly, the results generated from these experiments are very different than those obtained with the conventional vial model, and may more closely resemble in vivo data. [20][21][22][23][24][25] Thus, developing an intricate in vitro eye model to examine CLs will provide new insights on the interaction of lens materials with the ocular surface, and help facilitate the development of new materials and new applications for CLs in the coming decades.…”

Factors that Influence In Vitro Cholesterol Deposition on Contact Lenses

“…Pucker and colleagues 18 also examined the in vitro uptake of lipids, exposing the lens materials to straight lipid solutions, showing higher uptake rates than reported in this article. 54 Other differences in ATS concentrations, measuring techniques, examined lipids, incubation solution, incubation volumes, and replenishment rates influence the degree of cholesterol uptake and make direct comparisons between experiments difficult. 18 It also differs from the ex vivo study of Maziarz et al, 28 in that our lenses were not exposed to the atmosphere during blinking, and recent work from our laboratory has shown that drying of the lens surface during the interblink period does increase lipid deposition.…”

The role of multi-purpose solutions in prevention and removal of lipid depositions on contact lenses

“…A few previous publications hinted that care solutions may have a role in removal of lipids from contact lenses [15,22]. Thus it seems feasible that they could also play a prophylactic role in reducing lipid sorption.…”