The impact of intrahepatic cholestasis of pregnancy on fetal cardiac and peripheral circulation

Abstract

Results:The Doppler parameters of fetal cardiac and peripheral circulation did not significantly differ between the two groups. S/D ratio readings in the ICP group were significantly above 2 SD before 35 weeks of gestation. Women with ICP had increased risks of preterm delivery, neonatal unit admission, and meconium-stained amniotic fluid compared with those in the controls. Keywords: Intrahepatic cholestasis of pregnancy, fetal Doppler, fetal cardiac circulation Received: 14 October, 2014 Accepted: 18 January, 2015 The impact of intrahepatic cholestasis of pregnancy on fetal cardiac and peripheral circulation Conclusion:

The impact of ursodeoxycholic acid treatment on myocardial performance index in the obstetric cholestasis cases

“…[24] These factors cause intermeasurement and intraobserver variations which may affect the result of the study. [22][23][24][25] The previous studies found interclass correlation coefficient 0.7-0.9 for MPI. [24][25][26][27] Similarly, although we found a shortening in AV conduction time, this finding should be evaluated carefully.…”

“…Previous studies reported that E/A ratio did not change in the cases with obstetric cholestasis. [23] It was found that the increase in peripheral Doppler resistance indices, which are the findings of hypoxia and asphyxia, did not fail in the cases with obstetric cholestasis. These findings show that there was a cardiac dysfunction in obstetric cholestasis but this dysfunction did not cause a prenatal asphyxia or hypoxia.…”

The effect of intrahepatic cholestasis of pregnancy and ursodeoxycholic acid treatment on Doppler parameters of fetal and maternal circulation

“…Suri et al [20] showed that a S/D ratio above 2 SD was significantly higher in pregnancies with ICP compared with gestation matched reference values of the umbilical artery of a normal healthy pregnant population, however adverse fetal outcome was not associated with Doppler findings. Kurtulmuş et al [21] found that UA and MCA Doppler S/D ratio, PI, and RI in pregnant women with ICP were not different when compared with healthy pregnant women. In our study there was no statistically significant difference between Doppler findings in the ICP group and the control group.…”