As the 21st century has begun, increased globalization and competitiveness have negatively affected closed innovation. with the rise of the digital economy and sharing economy, new ventures can no longer afford to depend solely on internal research and development innovation processes Shahzadi, 2021). There is a disappearance of enterprise boundaries, which requires enterprises to gain innovation capabilities from outside, hence the concept of open innovation. By implementing open innovation, new ventures are able to lower their research and development costs (Haar et al., 2021), reduce product development time (Aljanabi, 2022), achieve higher coordination among organizations, and generate more revenue (Zhu et al., 2019), as well as overcome existing lack of managerial or technical knowledge (Aleksić et al., 2021). Therefore, scholars and practitioners have recently shifted attention from traditional closed internal innovation to open innovation (Naseer et al., 2021). Open innovation refers to the deliberate use of inflows and outflows of knowledge and expansion of external markets for fostering innovation (Aljanabi, 2022;Chesbrough, 2003). Previously, studies have primarily examined open innovation's outcomes, while few have examined its antecedents. However, promoting and encouraging open innovation requires examining the driving factors of open innovation. For this reason, in an attempt to clarify the possible effects of these factors, the study explores the effects of high-performance work systems (HPWS) on open innovation under the mediating effects of the knowledge management process (KMP). Furthermore, knowledge worker productivity (KWP) is also examined for its role in moderating the relationship between the constructs to gain a deeper understanding. There are many motives for the paper to contribute significantly to the theory of HPWS, knowledge management, and open innovation. As one of various factors or antecedents that affect open innovation, A recent literature review emphasizes the importance of using an organization's human resources and