The impact of l-lanthionine supplementation on the production of nisin by lactococci

Feldeková, Eva; Solichová, K.; Horáčková, Šárka; Kumherová, Monika; Kyselka, Jan

doi:10.1007/s00217-020-03449-4

Cited by 2 publications

(1 citation statement)

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“…The fermentation process was organically combined with lower cost L‐lanthionine , and the medium MI7 (0.5% W/W) was added to stimulate the synthesis of nisin by Lactococci . It was found that the addition of L‐Lan had a significant effect on the synthesis of nisin, and the concentrations of nisin in strains CCDM731 and LTM 32 were increased by 88.6% and 90.0% (Feldeková et al., 2020).…”

Section: Optimization Of Nisin Productionmentioning

confidence: 99%

Synthesis, high yield strategy and application of nisin: A review

Wang

Sheng

Huang

et al. 2023

Int J of Food Sci Tech

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Nisin is a peptide with antibacterial activity against a variety of pathogens. It was originally obtained from a Lactococcus lactis. It is classified as a class I bacteriocin, as it is synthesised by ribosomes and post-translationally modified. It has been studied extensively and has a wide range of applications in the food industry, biomedicine, veterinary, and research fields. It is approved as a food preservative by the Food and Agriculture Organization (FAO). What's more, nisin, the only antimicrobial peptide that has generally considered as safe (GRAS) status from both World Health Organization (WHO) and Food and Drug Administration (FDA), has the potential to become an important natural antibiotic as bacteria become more resistant to traditional antibiotics. However, nisin purified from biological sources usually results in low yields and high production costs, limiting industrial-scale manufacturing and application in other fields. Hence, more methods need to be used to optimise the production of nisin. Therefore, this paper aimed to understand the structure and biosynthesis mechanism of nisin and to summarise the innovative methods for increasing the production of nisin using biosynthesis regulation.

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Section: Optimization Of Nisin Productionmentioning

confidence: 99%