The impact of Lactobacillus and Bifidobacterium probiotic cocktail on modulation of gene expression of gap junctions dysregulated by intestinal pathogens

Miri, Seyedeh Tina; Sotoodehnejadnematalahi, Fattah; Amiri, Mohammad Mehdi; Pourshafie, Mohammad Reza; Rohani, Mahdi

doi:10.1007/s00203-022-03026-1

Cited by 11 publications

(4 citation statements)

References 33 publications

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“…Various conditions which disrupt the balance and diversity of gut microbiota (dysbiosis) and intestinal homeostasis lead to the growth of pathogens and the consequent initiation of systemic inflammation. Lifestyle, diet, antibiotic consumption, environmental factors and stress conditions include potential risk factors (Jostins et al 2012 ; Sheehan et al 2015 ; Statovci et al 2017 ; Cui and Yuan 2018 ; Piovani et al 2019 ; Andreou et al 2020 ; Miri et al 2022 ). The gut microbiota dysbiosis in the IBD can be translated into a decrease in Suterella , Bacteroides and Saccharomyces cervisiae , Faecalibacterium prausnitzii , Roseburia species, Bifidobacterium spp and Groups IV and XIVA of Clostridium (Rivière et al 2016 ; Pavel et al 2021a ).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, probiotics mitigate the risk of hereditary IBD. Lactobacillus and Bifidobacterium species figure out between the major probiotics play key roles in GIT health, applied to heal IBD or UC complications (Pavel et al 2021a ; Miri et al 2022 ). Figures 1 and 2 describe the variety of mechanisms by which the gut microbiota contribute to protect the mucosal barrier and to prevent epithelial inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Protective role of flavonoids quercetin and silymarin in the viral-associated inflammatory bowel disease: an updated review

Zarenezhad

Abdulabbas

Kareem³

et al. 2023

Arch Microbiol

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Inflammatory bowel disease (IBD) is a chronic recurrent inflammation of the gastrointestinal tract (GIT). IBD patients are susceptible to various infections such as viral infections due to the long-term consumption of immunosuppressive drugs and biologics. The antiviral and IBD protective traits of flavonoids have not been entirely investigated. This study objective included an overview of the protective role of flavonoids quercetin and silymarin in viral-associated IBD. Several viral agents such as cytomegalovirus (CMV), Epstein–Barr virus (EBV), varicella zoster virus (VZV) and enteric viruses can be reactivated and thus develop or exacerbate the IBD conditions or eventually facilitate the disease remission. Flavonoids such as quercetin and silymarin are non-toxic and safe bioactive compounds with remarkable anti-oxidant, anti-inflammatory and anti-viral effects. Mechanisms of anti-inflammatory and antiviral effects of silymarin and quercetin mainly include immune modulation and inhibition of caspase enzymes, viral binding and replication, RNA synthesis, viral proteases and viral assembly. In the nutraceutical sector, natural flavonoids low bioavailability and solubility necessitate the application of delivery systems to enhance their efficacy. This review study provided an updated understanding of the protective role of quercetin and silymarin against viral-associated IBD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective role of flavonoids quercetin and silymarin in the viral-associated inflammatory bowel disease: an updated review

Zarenezhad

Abdulabbas

Kareem³

et al. 2023

Arch Microbiol

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“…The process of gastric ulcer healing entails a carefully orchestrated interplay of various mechanisms, restoring the equilibrium between deleterious and protective factors [13,14,92,93]. Among the probiotics extensively investigated for treating and preventing gastrointestinal disorders, lactobacilli and bifidobacteria species emerge as leading candidates [24,69,94]. These bacterial species exhibit remarkable resilience in the face of the challenging luminal conditions within the gastrointestinal tract [95,96].…”

Section: Discussionmentioning

confidence: 99%

Unravelling the Gastroprotective Potential of Kefir: Exploring Antioxidant Effects in Preventing Gastric Ulcers

Côco,

Aires,

Carvalho

et al. 2023

Cells

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The present study was conducted to evaluate the protective effect of milk kefir against NSAID-induced gastric ulcers. Male Swiss mice were divided into three groups: control (Vehicle; UHT milk at a dose of 0.3 mL/100 g), proton pump inhibitor (PPI; lansoprazole 30 mg/kg), and 4% milk kefir (Kefir; 0.3 mL/100 g). After 14 days of treatment, gastric ulcer was induced by oral administration of indomethacin (40 mg/kg). Reactive oxygen species (ROS), nitric oxide (NO), DNA content, cellular apoptosis, IL-10 and TNF-α levels, and myeloperoxidase (MPO) enzyme activity were determined. The interaction networks between NADPH oxidase 2 and kefir peptides 1–35 were determined using the Residue Interaction Network Generator (RING) webserver. Pretreatment with kefir for 14 days prevented gastric lesions. In addition, kefir administration reduced ROS production, DNA fragmentation, apoptosis, and TNF-α systemic levels. Simultaneously, kefir increased NO bioavailability in gastric cells and IL-10 systemic levels. A total of 35 kefir peptides showed affinity with NADPH oxidase 2. These findings suggest that the gastroprotective effect of kefir is due to its antioxidant and anti-inflammatory properties. Kefir could be a promising natural therapy for gastric ulcers, opening new perspectives for future research.

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“…Lu et al [ 141 ] showed that B. animalis sup F1-7 might function as a potent activator to module the immunological response by supporting the expression of caspase 8/3, the Bid and Bak genes and proteins as well as by activating the FAS/CD95 pathway. In the study by Miri et al [ 142 ], the expression of cell junctions was influenced by the strains of Lactobacillus and Bifidobacterium , which may have modulated homeostasis.…”

Section: Impact Of Probiotic Fruits and Vegetable Juice On Human Healthmentioning

confidence: 99%

Recent advances in probiotication of fruit and vegetable juices

Rahman,

Emon,

Toma

et al. 2023

J Adv Vet Anim Res

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Probiotics are live bacteria beneficial to health when consumed adequately. Health professionals now recommend probiotics on regular diets due to their positive effects on human health. The probiotics that are usually consumed from the market through food products are mostly dairy-based. Fruit and vegetables are gaining popularity as preferred matrices for probiotic carriers to the human body, owing to their high cholesterol content and the lactose intolerance of dairy products. On the other hand, fruits and vegetable juices are rich in nutrient content such as vita¬mins, minerals, and antioxidants and do not contain a starter culture that can compete with the nutrients. The probiotication of fruit and vegetable juices (apple, carrot, citrus fruit, pomegranate, watermelon, tomato, and pineapple) are performing as efficient probiotic bacteria carriers. This review covers the previous works that highlighted the variety of probiotic fruit and vegetable juices as well as the viability of each probiotic in various products after proper fermentation and storage. In addition, physicochemical and sensory changes that occurred during the processing and storage period have been discussed. Furthermore, strategies (microencapsulation, adding prebiotics, antioxidant addition, maintaining optimum pH, temperature, adaptation with resis¬tance, and good packaging) to improve the stability of probiotic bacteria are outlined, as it is difficult to maintain the stability of probiotic bacteria during storage. Finally, the manuscript discusses the effect of probiotic fruit and vegetable juices on human health.

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The impact of Lactobacillus and Bifidobacterium probiotic cocktail on modulation of gene expression of gap junctions dysregulated by intestinal pathogens

Cited by 11 publications

References 33 publications

Protective role of flavonoids quercetin and silymarin in the viral-associated inflammatory bowel disease: an updated review

Protective role of flavonoids quercetin and silymarin in the viral-associated inflammatory bowel disease: an updated review

Unravelling the Gastroprotective Potential of Kefir: Exploring Antioxidant Effects in Preventing Gastric Ulcers

Recent advances in probiotication of fruit and vegetable juices

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