The impact of laparoscopic cystectomy on ovarian reserve in patients with unilateral and bilateral endometrioma

Kashi, Abolfazl Mehdizadeh; Chaichian, Shahla; Ariana, Shideh; Fazaeli, Masoumeh; Moradi, Yousef; Rashidi, Mandana; Najmi, Zahra

doi:10.1002/ijgo.12046

Cited by 35 publications

(25 citation statements)

References 21 publications

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“…These results are in agreement with Kashi et al [23] who concluded from his study that Laparoscopic cystectomy was associated with post-operative decreases in serum AMH, particularly with bilateral involvement (p value in bilateral = 0.029 and in unilateral = 0.046) and endometriomas at least 50 mm in diameter ( p value in ≥ 50mm was < 0.001 and in <50mm was 0.015).…”

Section: Discussionsupporting

confidence: 92%

Effect of Laparoscopic Ovarian Cystectomy for Endometrioma on Ovarian Reserve

Elhameid¹,

Amin²,

Alnemr³

et al. 2018

Zagazig University Medical Journal

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Background: To assess the effect of laparoscopic ovarian cystectomy for endometrioma on ovarian reserve by markers as Anti-Mullerian Hormone and Follicle Stimulating Hormone. Subjects: 48 Women of reproductive age who had ultrasonographic diagnosis of endometrioma measuring>3cm whether unilateral or bilateral and subjected to laparoscopic excision. Methods: From January 2017 to December 2017, Women with endometrioma underwent to laparoscopic excision. Serum AMH and FSH were determined preoperatively and 3months postoperative. Results: There was a statistically significant reduction in postoperative mean value of AMH (2.04+ 1.69) when compared to the preoperative mean value of AMH (2.59+ 1.85) and a statistically significant rise in postoperative mean value of serum FSH (7.23+ 1.48), when compared to preoperative mean value of FSH (5.50+ 1.85). Post-operative AMH decreases were greater in patients with endometriomas > 5cm in diameter compared with smaller ones and in patients with bilateral endometriomas compared with unilateral ones. Conclusion: Laparoscopic cystectomy for endometrioma has an adverse impact on ovarian reserve. Bilaterality and size of endometrioma increase the adverse effect of Laparocopic ovarian cystectomy on the ovarian reserve.

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Section: Discussionsupporting

confidence: 92%

Effect of Laparoscopic Ovarian Cystectomy for Endometrioma on Ovarian Reserve

Elhameid¹,

Amin²,

Alnemr³

et al. 2018

Zagazig University Medical Journal

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“…Other factors could also affect the ovarian reserve, such as cyst size, laterality of the endometriomas, and surgical skill of the physician performing cyst stripping . However, scientific data regarding these factors are contradictory and the mentioned variables might not have any tangible influence .…”

Section: Discussionmentioning

confidence: 99%

Systematic review and meta‐analysis of the effect of bipolar electrocoagulation during laparoscopic ovarian endometrioma stripping on ovarian reserve

Deckers

Ribeiro

Simões

et al. 2017

Intl J Gynecology & Obste

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“…Apart from AFC and basal hormone, anti-Müllerian hormone (AMH) level is also demonstrated to predict the magnitude of ovarian reserve as well as controlled ovarian stimulation (COS) responses [18,22]. Endometrioma cystectomy, especially bilateral surgery, is deleterious with respect to ovarian reserve for AMH, which decreased significantly based on a recent systematic review and meta-analysis and previous studies [12,18,23,24].…”

Section: Introductionmentioning

confidence: 99%

Live birth rate comparison of three controlled ovarian stimulation protocols for in vitro fertilization-embryo transfer in patients with diminished ovarian reserve after endometrioma cystectomy: a retrospective study

et al. 2020

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Background: Women with endometriosis and previous cystectomy may respond less well to gonadotropin stimulation, which results in fewer oocytes retrieved and poor pregnancy outcomes. Choosing an appropriate protocol for such populations is essential. This study involved an analysis of the effect of different controlled ovarian stimulation (COS) protocols on the clinical outcomes of in vitro fertilization-embryo transfer (IVF-ET) in women with diminished ovarian reserve (DOR) who underwent ovarian endometrioma cystectomy. Methods: A total of 342 patients that underwent IVF-ET treatment at the Beijing Obstetrics and Gynecology Hospital from January 1, 2013 to April 30, 2018 were included in this retrospective study. The patients were distributed into three groups according to the COS protocols, namely prolonged GnRH-agonist (Group A, n = 113), GnRH-antagonist (Group B, n = 121), and long GnRH-agonist (Group C, n = 108). The clinical and laboratory parameters of the three protocols were analyzed and a logistic regression of clinical pregnancy and live births was conducted. Results: There were no significant differences in the age, infertility duration, basic follicle stimulation hormone (FSH), luteinizing hormone (LH), or estradiol (E 2 ) levels as well as other baseline characteristics among groups (P > 0.05). The total gonadotrophin (Gn) dosage and duration tended to be less in the GnRH-antagonist group than in the others (P < 0.05). No significant differences were found in the implantation rate and clinical pregnancy rate among the groups, but the prolonged GnRH-agonist group showed the highest rates. In addition, no significant differences were present in the number of retrieved oocytes, oocyte fertilization rate, embryo utilization rate, live birth rate, abortion rate, ectopic pregnancy rate, or multiple pregnancy rate in the three groups (P > 0.05). Age had a significant effect on both clinical pregnancy and live birth. Conclusion:For those DOR patients who had undergone ovarian endometriosis cystectomy, the prolonged GnRHagonist protocol may achieve better clinical IVF-ET outcomes, but there were no significant differences from the other groups. The GnRH-antagonist protocol may reduce the cost and time of drug treatment. Age should be considered for its influence on pregnancy outcome. However, a larger sample size may be needed for further study.

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The impact of laparoscopic cystectomy on ovarian reserve in patients with unilateral and bilateral endometrioma

Abstract: Laparoscopic cystectomy was associated with post-operative decreases in serum AMH, particularly with bilateral involvement and endometriomas at least 50 mm in diameter.

Cited by 35 publications

References 21 publications

Effect of Laparoscopic Ovarian Cystectomy for Endometrioma on Ovarian Reserve

Effect of Laparoscopic Ovarian Cystectomy for Endometrioma on Ovarian Reserve

Systematic review and meta‐analysis of the effect of bipolar electrocoagulation during laparoscopic ovarian endometrioma stripping on ovarian reserve

Live birth rate comparison of three controlled ovarian stimulation protocols for in vitro fertilization-embryo transfer in patients with diminished ovarian reserve after endometrioma cystectomy: a retrospective study

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