The Impact of Laparoscopic Sleeve Gastrectomy with Duodenojejunal Bypass on Intestinal Microbiota Differs from that of Laparoscopic Sleeve Gastrectomy in Japanese Patients with Obesity

Kikuchi, R.; Irie, Junichiro; Yamada-Goto, Nobuko; Kikkawa, Eri; Seki, Yosuke; Kasama, Kazunori; Itoh, Hiroshi

doi:10.1007/s40261-018-0638-0

Cited by 20 publications

(15 citation statements)

References 39 publications

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“…These results might derive from reduced food intake after LSG. Otherwise, gut microbiota can metabolize EAA and choline [19][20][21] ; thus, alterations in the gut microbiota after LSG, as has been previously reported [22][23][24] , might help explain the reductions in EAA and choline levels. Given that gut microbiota differ among ethnicities, it might be better to establish evidence in each country.…”

Section: Discussionmentioning

confidence: 73%

Metabolic alterations in plasma after laparoscopic sleeve gastrectomy

Yoshida

Kitahama

Yamashita

et al. 2020

J of Diabetes Invest

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Laparoscopic sleeve gastrectomy (LSG) is an important therapeutic option for morbidly obese patients. Although LSG promotes sufficient weight loss, how LSG changes plasma metabolites remains unclear. We assessed changes in plasma metabolite levels after LSG. We collected plasma samples from 15 morbidly obese Japanese patients before and 3 months after LSG. A total of 48 metabolites were quantified using capillary electrophoresis time-of-flight mass spectrometry-based metabolomic profiling. Branched chain amino acids, several essential amino acids, choline, 2-hydroxybutyric acid, 2-oxoisovaleric acid and hypoxanthine were significantly decreased after LSG. Tricarboxylic acid cycle metabolites, including citric acid, succinic acid and malic acid, were significantly elevated after LSG. This is the first report to show dynamic alterations in plasma metabolite concentrations, as assessed using capillary electrophoresis time-of-flight mass spectrometry, in morbidly obese patients after LSG. Our results might show how LSG helps improve obesity, in part through metabolic status changes, and propose novel therapeutic targets to ameliorate obesity.

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Section: Discussionmentioning

confidence: 73%

Metabolic alterations in plasma after laparoscopic sleeve gastrectomy

Yoshida

Kitahama

Yamashita

et al. 2020

J of Diabetes Invest

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“…There were comparable benefits in weight loss, glycemic control, insulin resistance, β‐cell function, lipids, and uric acid compared with LRYGB . Interestingly, the LDJB‐LSG affected intestinal microbiota differently than SG alone .…”

Section: Executive Summarymentioning

confidence: 94%

Clinical Practice Guidelines for the Perioperative Nutrition, Metabolic, and Nonsurgical Support of Patients Undergoing Bariatric Procedures – 2019 Update: Cosponsored by American Association of Clinical Endocrinologists/American College of Endocrinology, The Obesity Society, American Society for Metabolic and Bariatric Surgery, Obesity Medicine Association, and American Society of Anesthesiologists

Mechanick

Apovian

Brethauer

et al. 2020

Obesity

340

464

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Objective The development of these updated clinical practice guidelines (CPGs) was commissioned by the American Association of Clinical Endocrinologists (AACE), The Obesity Society (TOS), American Society for Metabolic and Bariatric Surgery (ASMBS), Obesity Medicine Association (OMA), and American Society of Anesthesiologists (ASA) Boards of Directors in adherence with the AACE 2017 protocol for standardized production of CPGs, algorithms, and checklists. Methods Each recommendation was evaluated and updated based on new evidence from 2013 to the present and subjective factors provided by experts. Results New or updated topics in this CPG include: contextualization in an adiposity‐based chronic disease complications‐centric model, nuance‐based and algorithm/checklist‐assisted clinical decision‐making about procedure selection, novel bariatric procedures, enhanced recovery after bariatric surgery protocols, and logistical concerns (including cost factors) in the current health care arena. There are 85 numbered recommendations that have updated supporting evidence, of which 61 are revised and 12 are new. Noting that there can be multiple recommendation statements within a single numbered recommendation, there are 31 (13%) Grade A, 42 (17%) Grade B, 72 (29%) Grade C, and 101 (41%) Grade D recommendations. There are 858 citations, of which 81 (9.4%) are evidence level (EL) 1 (highest), 562 (65.5%) are EL 2, 72 (8.4%) are EL 3, and 143 (16.7%) are EL 4 (lowest). Conclusions Bariatric procedures remain a safe and effective intervention for higher‐risk patients with obesity. Clinical decision‐making should be evidence based within the context of a chronic disease. A team approach to perioperative care is mandatory, with special attention to nutritional and metabolic issues.

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“…Furthermore, the possibility that gastrointestinal hormones other than CCK that were changed by SG and that might contribute to reduced BP, as well as downregulate RSNA and RAS activity, cannot be excluded, although we could examine only PYY and GLP‐1 as gastrointestinal hormones other than CCK. Third, it is known that SG alters microbiota , particularly by increasing lactobacilli. Another previous study reported that Lactobacillus murinus reduced salt‐sensitive hypertension in mice .…”

Section: Discussionmentioning

confidence: 99%

Effects of Sleeve Gastrectomy on Blood Pressure and the Renal Renin–Angiotensin System in Rats with Diet‐Induced Obesity

Yoshida

Gotoh

Masaki

et al. 2019

Obesity

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Objective Sleeve gastrectomy (SG) has been reported to decrease blood pressure (BP), although the reason has not been revealed. The present study aimed to establish the reason why SG decreases BP. Methods Male Sprague–Dawley rats were subjected to surgical (sham operation or SG) and dietary interventions (fed a normal diet or high‐fat diet ad libitum or fed by pair‐feeding [PF]). Systolic BP (SBP), urinary sodium excretion, and endocrine parameters were examined 4 weeks after surgery. Results Both SG and PF rats had reduced body weight compared with SO rats fed normal diet or high‐fat diet ad libitum. SG rats exhibited a reduction in SBP compared with PF, which was associated with a reduction in renal renin, angiotensin II, and catechol‐O‐methyltransferase levels (P < 0.01 for each). SG increased plasma cholecystokinin (CCK) levels compared with PF (P < 0.0001 for each), whereas glucagon‐like peptide 1 and peptide YY were not changed in fasting. Exogenous administration of CCK reduced renal catechol‐O‐methyltransferase (P = 0.0233), renin (P < 0.0001), and angiotensin II (P < 0.0001) levels and SBP (P = 0.0053). Conclusions SG reduced SBP, at least in part, through suppression of sympathetic nerve action by elevation of CCK, which was followed by suppression of the intrarenal renin–angiotensin system.

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The Impact of Laparoscopic Sleeve Gastrectomy with Duodenojejunal Bypass on Intestinal Microbiota Differs from that of Laparoscopic Sleeve Gastrectomy in Japanese Patients with Obesity

Cited by 20 publications

References 39 publications

Metabolic alterations in plasma after laparoscopic sleeve gastrectomy

Metabolic alterations in plasma after laparoscopic sleeve gastrectomy

Effects of Sleeve Gastrectomy on Blood Pressure and the Renal Renin–Angiotensin System in Rats with Diet‐Induced Obesity

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