The impact of laryngeal dysplasia on the development of laryngeal squamous cell carcinoma

Lüers, Jan Christoffer; Sircar, Keya; Drebber, Uta; Beutner, Dirk

doi:10.1007/s00405-013-2670-2

Cited by 18 publications

(25 citation statements)

References 26 publications

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“…Two studies did not specify this time interval for each grade of dysplasia. The mean time interval in the other studies ranged from 25 to 65 months in patients with mild dysplasia, from 17 to 68 months in those with moderate dysplasia. and from 10 to 192 months in patients with severe dysplasia and CIS combined.…”

Section: Resultsmentioning

confidence: 77%

“…The risk of malignant transformation in the group with mild dysplasia is relatively low in nearly all studies (0.0% to 26.9%) . Differences in transformation rates between the groups with moderate and severe dysplasia and CIS are less distinct.…”

Section: Discussionmentioning

confidence: 84%

“…However, Blackwell et al did not show an increased risk of malignant transformation for CIS compared with the other grades of dysplasia. Three studies showed a substantial increase in the risk of malignant transformation when comparing the categories mild and moderate dysplasia, but failed to report an increase in risk of malignant transformation when comparing the categories moderate and severe dysplasia/CIS.…”

Section: Resultsmentioning

confidence: 98%

“…The assessment of the relevance and validity criteria are presented in Table . All of the included studies were highly relevant. In 2 studies, a substantial amount of data was missing .…”

Section: Resultsmentioning

confidence: 99%

“…Results for severe dysplasia and CIS are shown separately when available. Luers et al did analyze CIS separately from severe dysplasia, but included all patients with CIS in the carcinoma group. Therefore, it was not possible to include a subgroup of CIS for this study in our analyses.…”

Section: Resultsmentioning

confidence: 99%

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Grade of dysplasia and malignant transformation in adults with premalignant laryngeal lesions

et al. 2015

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The risk of malignant transformation seems to increase with the grade of dysplasia, although percentages between studies are highly dissimilar. The wide variety and overlapping 95% CIs make it difficult to formulate a strong recommendation. However, moderate dysplasia is more prone for malignant transformation than previously thought, which might influence follow-up and treatment decisions in the future. © 2015 Wiley Periodicals, Head Neck 38: E2284-E2290, 2016.

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Section: Resultsmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 84%

Section: Resultsmentioning

confidence: 98%

“…The assessment of the relevance and validity criteria are presented in Table . All of the included studies were highly relevant. In 2 studies, a substantial amount of data was missing .…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Grade of dysplasia and malignant transformation in adults with premalignant laryngeal lesions

et al. 2015

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Malignant Transformation of Dysplastic Vocal Fold Lesions

Horton,

Philteos,

Lin

2024

JAMA Otolaryngol Head Neck Surg

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ImportanceThe reported rates of malignant transformation of dysplastic laryngeal lesions are highly variable, as is time to malignant degeneration.ObjectiveTo evaluate the rate of and time to malignant transformation of dysplastic laryngeal lesions based on the World Health Organization (WHO) dysplasia classification system.Data SourcesPubMed, MEDLINE, Embase, CINAHL, CENTRAL, and Cochrane Reviews were searched from the date of database inception to June 8, 2023.Study SelectionEnglish-language articles assessing the rate of malignant transformation using the 2005 WHO dysplasia classification system were included in this systematic review and meta-analysis.Data Extraction and SynthesisThe study was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline. Data extraction was performed by 2 independent investigators. Study quality was assessed using a validated quality tool. When possible, data were pooled using random-effects meta-analysis.Main Outcome MeasuresThe primary outcome measure was the malignant transformation rate in each laryngeal dysplasia category. Secondary outcome measure was the time interval over which malignant transformation had occurred.ResultsA total of 5585 records were screened, 61 full texts were assessed, and 18 retrospective cohort studies with 3243 participants were included in the final review. The weighted pooled mean malignant transformation rates of mildly, moderately, and severely dysplastic lesions were 10.9%, 23.3%, and 30.5%, respectively. Malignant transformation rate of nondysplastic laryngeal lesions was 4.5%. Moderately and severely dysplastic lesions had significantly higher odds of malignant transformation compared with mildly dysplastic lesions (moderate: odds ratio [OR], 2.90 [95% CI, 2.06-4.09]; I2 = 0%; severe: OR, 3.42 [95% CI, 2.11-5.52]; I2 = 40%). Lesions without dysplasia had a significantly lower odds of malignant transformation compared with lesions with mild dysplasia (OR, 0.48; 95% CI, 0.28-0.81; I2 = 0%). The overall mean time to malignant transformation was 28.8 months (range, 22.0-35.6 months) for all dysplasia grades.Conclusion and RelevanceThis systematic review and meta-analysis found that the rate of malignant transformation increased with the grade of laryngeal dysplasia. Moderately dysplastic lesions were more likely to undergo malignant degeneration compared with mildly dysplastic lesions.

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Site-specific familial risk and survival of familial and sporadic head and neck cancer

et al. 2017

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The vast majority of head and neck cancers (HNCs) are sporadic squamous cell carcinomas, smoking and heavy drinking being the main risk factors. However, little is known about the possible role of family history and the importance of inherited factors versus shared environment. We used Swedish population-based registries to study the family history of HNC. In order to estimate the risk for family members to get the same cancer, and the risk for cancer-specific death in patients with a family history of HNC compared with patients without a family history, multivariate Cox proportional hazards analyses were performed. A 1.43-fold increased risk for developing HNC in the first-degree relatives (FDRs) of HNC patients [hazard ratio (HR), 1.43; 95% CI, 1.28-1.61] was found, when compared with relatives of healthy controls. In spouses of patients with HNC, the risk for developing any HNC was moderately increased (HR, 1.25; 95% CI, 1.01-1.53), compared with spouses of healthy controls. In addition, a 1.34-fold increased risk for death of HNC was found in HNC patients with a family history of HNC (HR, 1.34; 95% CI, (1.03-1.73) compared with HNC patients without a family history. We found an increased risk for HNC in relatives and spouses of HNC patients, when compared with family members of healthy controls. This suggests that in addition to inherited factors, shared environmental factors have a significant role in the development of the cancer. Family history of HNC was associated with worse survival in a newly diagnosed HNC patient.

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The impact of laryngeal dysplasia on the development of laryngeal squamous cell carcinoma

Cited by 18 publications

References 26 publications

Grade of dysplasia and malignant transformation in adults with premalignant laryngeal lesions

Grade of dysplasia and malignant transformation in adults with premalignant laryngeal lesions

Malignant Transformation of Dysplastic Vocal Fold Lesions

Site-specific familial risk and survival of familial and sporadic head and neck cancer

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