There is a lack of access to emergency surgical care in developing countries despite a burden of surgical disease. 1 Health care systems are overwhelmed by the high volume of patients who need acute care and by insufficient capacity because of a lack of appropriate prehospital care, surgery-capable clinicians, and basic health care delivery infrastructures. 2 Compared with high-income countries where mortality from peritonitis is less than 5%, mortality in this resource-poor setting is nearly 20%. 1,3 These patients are particularly sus-ceptible because of a lack of the prerequisite surgical infrastructure, which includes prompt triage and diagnosis, early transfer to a higher level of care, timely surgical intervention, and critical care services. 4 This study identifies outcomes of patients with peritonitis and factors that contribute to mortality.Methods | This is a prospective observational study of patients at Kamuzu Central Hospital in Lilongwe, Malawi, presenting with acute abdominal complaints from September 2013 through March 2016. The University of North Carolina institutional review board and the Malawi National Health Services review committee approved this study and waived con-