“…The adaptive responses of mycobacteria to stress have been extensively analysed by transcriptional profiling in well-defined experimental models (Stewart et al, 2002;Betts et al, 2002;Deb et al, 2009;Rohde et al, 2012;Galagan et al, 2013;Rustad et al, 2014;Namouchi et al, 2016;Aguilar-Ayala et al, 2017;Martini et al, 2019). However, due to the well-established poor correlation between levels of mRNA transcripts and proteins in the cell (Cortes et al, 2017;Haider and Pal, 2013) and differences in mRNA and protein half-lives (Nguyen et al, 2020), it is unclear how the changes that occur in the transcriptome of bacteria that enter a persistent state play out in the proteome. Clearly, there are post-transcriptional control mechanisms that influence protein abundance, but these are currently poorly understood in mycobacteria.…”