The Impact of Lens Opacity on SD-OCT Retinal Nerve Fiber Layer and Bruch's Membrane Opening Measurements Using the Anatomical Positioning System (APS)

Mauschitz, Matthias M.; Roth, Felix; Holz, Frank G.; Breteler, Monique M.B.; Finger, Robert P.

doi:10.1167/iovs.17-21675

Cited by 7 publications

(4 citation statements)

References 37 publications

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“…They suggested that “optic disc cupping reversal” following the relative ocular hypotony after FLALS might have some tissue-expanding effect similar to that observed after glaucoma surgery, causing the postoperative increase in BMO-MRW. Although Mauschitz et al [ 12 ] reported that RNFLT, BMO area, and BMO-MRW, taken by SD-OCT, remained unchanged after cataract surgery, they differ from our study in that they performed OCT examination on the 1st postoperative day and conducted only on normal subjects.…”

Section: Discussioncontrasting

confidence: 89%

“…Kim et al [ 20 ] reported a significant change in the signal strength values and RNFLT measurements 8 weeks after cataract extraction. The ΔRNFLT and Δsignal strength can be explained by the fact that light attenuation and light scattering induced by cataract might cause the change in RNFLT after cataract surgery [ 12 ]. Mwanza et al [ 15 ] showed that cataract may reduce RNFLT measurements on OCT images and therefore these measurements should be interpreted with caution, especially in eyes with advanced cataract where SS is much attenuated.…”

Section: Discussionmentioning

confidence: 99%

“…6.0) scanning preoperatively and postoperatively at 6 months by the ONH acquisition protocol available in the new Glaucoma Module Premium Edition with automatic real time function for noise reduction. Additionally, OCT imaging used anatomical positioning system which recognizes individual anatomic landmarks and provides the exact placement of subsequent scans at the center of the fovea and the center of the BMO, creating a fovea-BMO center axis [ 12 ]. The image quality (Q) was obtained with a Q score which is a term for signal strength.…”

Section: Methodsmentioning

confidence: 99%

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Changes of Optical Coherence Tomography Parameters after Cataract Surgery in Primary Open-Angle Glaucoma Eyes

Kim

2023

Korean J Ophthalmol

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Purpose: To investigate the impact of uncomplicated cataract surgery on the measurement of Bruch's membrane opening-minimum rim width (BMO-MRW) and retinal nerve fiber layer thickness (RNFLT) using spectral domain optical coherence tomography (SD-OCT) in primary open-angle glaucoma (POAG) patients.Methods: This retrospective study included 63 eyes of 63 patients, including 32 POAG eyes and 31 normal eyes who underwent uneventful cataract surgery and follow-up for at least 6 months. Using SD-OCT, BMO-MRW and RNFLT were measured preoperatively and postoperatively at 6 months. Paired ttest was used to compare IOP, BMO-MRW, RNFLT, and image quality before and after surgery. These parameters and their changes were compared between POAG and normal groups. Univariate and multivariate linear regression analyses were performed to determine the factors associated with the postoperative change in RNFLT (ΔRNFLT) and BMO-MRW (ΔBMO-MRW).Results: BMO-MRW and RNFLT were significantly increased and IOP was decreased after phacoemulsification in both groups (P <0.001, respectively). The ΔRNFLT was significantly greater in POAG eyes compared with the normal eyes (P <0.001). The ΔRNFLT was associated with the postoperative IOP reduction and glaucoma diagnosis (P <0.001 and P = 0.001, respectively). In the normal group, only the change of IOP (ΔIOP) had a significant influence on ΔRNFLT (P = 0.003), but in the POAG group, not only ΔIOP (P = 0.044) but also preoperative VF MD (P = 0.029) showed a significant influence. The change of ΔBMO-MRW showed no difference between POAG and normal eyes. Conclusion:The postoperative increase of RNFLT was significantly greater in the POAG group, and the postoperative increase of RNFLT was associated with the preoperative VF MD and ΔIOP in POAG eyes and with the ΔIOP in normal eyes. Our results imply that RNFLT is more affected than BMO-MRW in POAG eyes compared to normal eyes by cataract surgery.

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Section: Discussioncontrasting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Changes of Optical Coherence Tomography Parameters after Cataract Surgery in Primary Open-Angle Glaucoma Eyes

Kim

2023

Korean J Ophthalmol

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“…This holds true for the LQAF and PNS measurements as well. Mauschitz and colleagues, when assessing the impact of lens opacity on retinal nerve fibre layer measurements, used the raw densitometry values of Scheimpflug imaging rather than the PNS 28. Raw values might perform better than an ordinal-scaled score for image quality correlation as well.…”

Section: Discussionmentioning

confidence: 99%

Impact of lens autofluorescence and opacification on retinal imaging

von der Emde,

Rennen,

Vaisband

et al. 2024

BMJ Open Ophth

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BackgroundRetinal imaging, including fundus autofluorescence (FAF), strongly depends on the clearness of the optical media. Lens status is crucial since the ageing lens has both light-blocking and autofluorescence (AF) properties that distort image analysis. Here, we report both lens opacification and AF metrics and the effect on automated image quality assessment.Methods227 subjects (range: 19–89 years old) received quantitative AF of the lens (LQAF), Scheimpflug, anterior chamber optical coherence tomography as well as blue/green FAF (BAF/GAF), and infrared (IR) imaging. LQAF values, the Pentacam Nucleus Staging score and the relative lens reflectivity were extracted to estimate lens opacification. Mean opinion scores of FAF and IR image quality were compiled by medical readers. A regression model for predicting image quality was developed using a convolutional neural network (CNN). Correlation analysis was conducted to assess the association of lens scores, with retinal image quality derived from human or CNN annotations.ResultsRetinal image quality was generally high across all imaging modalities (IR (8.25±1.99) >GAF >BAF (6.6±3.13)). CNN image quality prediction was excellent (average mean absolute error (MAE) 0.9). Predictions were comparable to human grading. Overall, LQAF showed the highest correlation with image quality grading criteria for all imaging modalities (eg, Pearson correlation±CI −0.35 (−0.50 to 0.18) for BAF/LQAF). BAF image quality was most vulnerable to an increase in lenticular metrics, while IR (−0.19 (−0.38 to 0.01)) demonstrated the highest resilience.ConclusionThe use of CNN-based retinal image quality assessment achieved excellent results. The study highlights the vulnerability of BAF to lenticular remodelling. These results can aid in the development of cut-off values for clinical studies, ensuring reliable data collection for the monitoring of retinal diseases.

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Retinal Nerve Fibre Layer Thickness Increases with Decreasing Spectralis OCT Signal Strength in Normal Eyes

Strampe

Eldweik²,

Chaon

et al. 2019

Neuro-Ophthalmology

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The Impact of Lens Opacity on SD-OCT Retinal Nerve Fiber Layer and Bruch's Membrane Opening Measurements Using the Anatomical Positioning System (APS)

Cited by 7 publications

References 37 publications

Changes of Optical Coherence Tomography Parameters after Cataract Surgery in Primary Open-Angle Glaucoma Eyes

Changes of Optical Coherence Tomography Parameters after Cataract Surgery in Primary Open-Angle Glaucoma Eyes

Impact of lens autofluorescence and opacification on retinal imaging

Retinal Nerve Fibre Layer Thickness Increases with Decreasing Spectralis OCT Signal Strength in Normal Eyes

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