The impact of long-term conventional treatment for overlap syndrome (obstructive sleep apnea and chronic obstructive pulmonary disease) on concurrent erectile dysfunction

Abstract

Conventional treatment for OSA and COPD, has a positive effect on concurrent ED on the minority of patients. This effect is possibly due to the improvement of respiration during sleep with CPAP and of oxygenation with bronchodilators continuously. Of the improved men, one third was not satisfied with the impact of this treatment modality on their EF. It is likely that specific for ED treatment is needed in these individuals.

Factores relacionados con la presencia de disfunción eréctil en pacientes con síndrome de apnea obstructiva del sueño

“…1). De este modo, encontramos diferencias significativas (p = 0,023) entre pacientes con disfunció n leve (41 [21] apneas-hipopneas/hora) y grave (63 [18] apneas-hipopneas/ hora).…”

“…The prevalence of ED was 69%. We found significant differences in AHI between patients with mild and severe ED (41 [21] vs 63 [18], P = .023). ED was associated with hypertension (odds ratio [OR] = 3.56 [1.64-7.72]), hypercholesterolemia (OR = 7.19 [2.39-21.68]), diabetes mellitus type 2 (OR = 3.07 [1.02-9.48]) and ischemic heart disease (OR = 1.51…”

“…Se clasificó el grado de DE en 5 categorías: DE grave (puntuació n 5-7), DE moderada (8)(9)(10)(11), DE leve-moderada (12)(13)(14)(15)(16), DE leve (17)(18)(19)(20)(21) Conclusions: Patients with OSA have a high prevalence of ED, mainly in severe OSA. Factors influencing the presence of ED in patients with OSA are primarily age and hypercholesterolemia.…”

“…Existe una clara agregació n entre EPOC y SAOS, aumentando el efecto de cada uno por separado sobre la hipoxemia nocturna, mecanismo fisiopatoló gico implicado en la DE 18 . En nuestro estudio, para evitar un posible factor de confusió n excluimos pacientes con EPOC, ya que esta se ha asociado con un mayor riesgo de DE, mejorando esta disfunció n con el tratamiento broncodilatador.…”

Erectile dysfunction and disease-specific quality of life in patients with obstructive sleep apnea

“…20 Although further study should be conducted to investigate the relationship between NO and OSAS, the impairment of the vasoprotective function of NO as a result of respiratory disturbances during nighttime sleep may explain the association between OSAS and ED. 21 Testosterone has been proposed as another linking factor between ED and hypoxia, though it is controversial. Kö hler et al 22 reported that androgen deficiency was quite common in men with ED.…”