The impact of low serum cholinesterase levels on survival in patients with colorectal cancer

Takano, Yasuhiro; Haruki, Koichiro; Tsukihara, Shu; Ito, Daisuke; Kanno, Hironori; Son, Kyonsu; Hanyu, Nobuyoshi; Eto, Ken

doi:10.1007/s00384-022-04119-5

Cited by 14 publications

(5 citation statements)

References 28 publications

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“…Takano et al. reported that a low ChE group was related to a strong systemic inflammatory response and distant metastasis regardless of the T or N stage in CRC patients 32 . Although the sample size of the study was limited, it strongly supports our findings.…”

Section: Discussionsupporting

confidence: 87%

Preoperative serum cholinesterase as a prognostic factor in patients with colorectal cancer

Nakamura,

Seishima,

Matsui

et al. 2024

Annals of Gastroent Surgery

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AimSerum cholinesterase (ChE) levels are considered to reflect nutritional status. Although ChE has been well documented as a prognostic factor for some cancers, no clear consensus on its use for colorectal cancer (CRC) has been reached. The aim of this study was to investigate the relationship between preoperative serum ChE and postoperative long‐term prognosis in CRC patients.MethodsA total of 1053 CRC patients who underwent curative surgery were included in this study. The correlations between the preoperative ChE value and overall survival (OS) or cancer‐specific survival (CSS) were assessed. By dividing patients into two groups according to their ChE value, OS and CSS were compared between the groups.ResultsMultivariate analysis revealed that the continuous ChE value was a significant predictor of OS (hazard ratio, 0.996; 95% CI, 0.993–0.998; p = 0.002) and CSS (hazard ratio, 0.994; 95% CI, 0.991–0.998; p = 0.001), independent of other variables. The low‐ChE (≤234 U/L) group had a significantly poorer prognosis than the high‐ChE (>234 U/L) group for both OS (5‐year OS for low ChE and high ChE: 79.8% and 93.3%, respectively; p < 0.001) and CSS (5‐year CSS for low ChE and high ChE: 84.8% and 95.6%, respectively; p < 0.001).ConclusionsLower preoperative serum ChE levels are a predictive factor of poor prognosis for CRC patients. As serum ChE levels can be measured quickly and evaluated easily, ChE could become a useful marker for predicting the postoperative long‐term outcomes of CRC patients.

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Section: Discussionsupporting

confidence: 87%

Preoperative serum cholinesterase as a prognostic factor in patients with colorectal cancer

Nakamura,

Seishima,

Matsui

et al. 2024

Annals of Gastroent Surgery

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“…Additionally, Takano et al. identified sarcobesity, characterized by the simultaneous presence of visceral obesity, sarcopenia, and wound infection as independent indicators of incisional hernia in multivariate analysis after laparoscopic colorectal cancer surgery 9 . The debate persists regarding whether abdominal subcutaneous or visceral obesity plays a predominant role in IH development.…”

Section: Discussionmentioning

confidence: 99%

“…However, in recent years, scholars proposed that although BMI is an important risk factor for VH, it cannot differentiate between abdominal subcutaneous, visceral, and peripheral adiposity 7,8 . Evidence of these observational studies was based on small sample sizes and therefore might not fully confirm the causal relationship between adiposity distribution and VH 8,9 . Mendelian randomization (MR) is an ideal strategy to address these limitations 10 .…”

Section: Introductionmentioning

confidence: 99%

Causal relationship of obesity and adiposity distribution on risk of ventral hernia

Shi,

Wu,

Guo

et al. 2024

World j. surg.

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PurposeVentral hernia (VH) is a common surgical disease. Previous studies suggested that obesity is an important risk factor for VH. However, the causal relationship between fat distribution and the risk of VH is still unclear. This study used Mendelian randomization (MR) to evaluate their causal relationship.MethodsWe used the body mass index (BMI), body fat percentage, and body fat mass to represent general obesity and utilized the volume of abdominal subcutaneous adiposity tissue, visceral adiposity tissue, waist circumference, hip circumference, and waist‐to‐hip ratio to represent abdominal adiposity. The data were extracted from the large‐scale genome‐wide association study of European ancestry. We used two‐sample MR to infer causality, using multivariate MR to correct the effects of confounding factors.ResultsIncreased BMI, body fat percentage, body fat mass, visceral adiposity tissue, waist circumference, and hip circumference rather than subcutaneous adiposity tissue or waist‐to‐hip ratio, were causally associated with a higher risk of VH. The results of multivariate MR suggested that body fat percentage was causally associated with a higher risk of VH after adjusting for body mass index, diabetes, and smoking.ConclusionGeneral obesity, increased visceral adiposity tissue, waist circumference, and hip circumference rather than subcutaneous adiposity tissue or the waist‐to‐hip ratio were causally associated with a higher risk of VH. These findings provided a deeper understanding of the role that the distribution of adiposity plays in the mechanism of VH.

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“…We retrospectively analyzed data of consecutive patients with stage I-III CRC aged 65-98 years who underwent curative resection at Tokyo General Hospital and Kasai Shoikai Hospital between January 2014 and December 2020. Among them, 136 patients have been studied previously [14].…”

Section: Study Design and Populationmentioning

confidence: 99%

“…Among them, 136 patients have been studied previously. 11 Patient data included age, sex, body mass index (BMI), comorbidities (hypertension, diabetes mellitus, and cardiovascular disease), American Society of Anesthesiologists physical status (ASA-PS) score, 12 blood test results, surgical approach, tumor type and location, postoperative complications, and pathological findings. Additionally, we examined the following nutritional indices: neutrophil-to-lymphocyte ratio (NLR), 13 prognostic nutritional index (PNI), 14 and C-reactive protein to albumin (CRP/Alb) ratio.…”

Section: Study Design and Populationmentioning

confidence: 99%

Prognostic significance of osteosarcopenia in older adults with colorectal cancer

Takano¹,

Kodera

Tsukihara³

et al. 2023

Annals of Gastroent Surgery

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Osteopenia and sarcopenia, features of the aging process, are recognized as major health problems in an aging society. This study investigated the prognostic impact of osteosarcopenia, the coexistence of osteopenia and sarcopenia, in older adults undergoing curative resection for colorectal cancer. MethodsWe retrospectively reviewed data of older adults aged 65-98 years who had undergone curative resection for colorectal cancer. Osteopenia was evaluated by bone mineral density measurement in the midvertebral core of the 11th thoracic vertebra on preoperative computed tomography images.Sarcopenia was evaluated by measuring the skeletal muscle cross-sectional area at the third lumbar vertebra level. Osteosarcopenia was de ned as the coexistence of osteopenia and sarcopenia. We explored the relationship of preoperative osteosarcopenia with the disease-free and overall survival after curative resection. ResultsAmong the 325 patients included, osteosarcopenia had signi cantly lower overall survival rates than those with osteopenia (P<0.01) or sarcopenia alone (P=0.036). In the multivariate analysis, male sex (P=0.045), C-reactive protein-to-albumin ratio (P<0.01), osteosarcopenia (P<0.01), pathological T4 stage (P=0.023), and pathological N1/N2 stage (P<0.01) were independent predictors of disease-free survival, while age (P<0.01), male sex (P=0.049), C-reactive protein-to-albumin ratio (P<0.01), osteosarcopenia (P<0.01), pathological T4 stage (P=0.036), pathological N1/N2 stage (P<0.01), and carbohydrate antigen 19-9 (P=0.041) were independent predictors of overall survival. ConclusionsOsteosarcopenia was a strong predictor of poor outcomes in older adults undergoing curative resection for colorectal cancer, suggesting an important role of osteosarcopenia in an aging society.

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The impact of low serum cholinesterase levels on survival in patients with colorectal cancer

Cited by 14 publications

References 28 publications

Preoperative serum cholinesterase as a prognostic factor in patients with colorectal cancer

Preoperative serum cholinesterase as a prognostic factor in patients with colorectal cancer

Causal relationship of obesity and adiposity distribution on risk of ventral hernia

Prognostic significance of osteosarcopenia in older adults with colorectal cancer

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