The impact of lower urinary tract symptoms and comorbidities on quality of life: the BACH and UREPIK studies

Robertson, Chris; Link, Carol L.; Onel, Erol; Mazzetta, Chiara; Keech, M.; Hobbs, FD Richard; Fourcade, R.; Kiemeney, Lambertus A.; Lee, Chongwook; Boyle, Peter; McKinlay, John B.

doi:10.1111/j.1464-410x.2007.06609.x

Cited by 145 publications

(151 citation statements)

References 21 publications

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“…In our study, there was a positive correlation between age and LUTS, which is in accordance with the literature. Beside this, increase in LUTS has been associated with lower QoL, which is also consistent with the literature (27). In a different study, it has been indicated that there was a strong association between the presence of arthritis and LUTS.…”

Section: Discussionsupporting

confidence: 79%

“…While evaluating the effect of concomitant non-urological diseases and demographic data on QoL in our study, no relationship among disease duration, disease activity (DAS 28), the presence of comorbid chronic diseases, and liquid intake habits was observed. However, a positive correlation between comorbid chronic diseases and LUTS has been observed in population-based studies (27).…”

Section: Discussionmentioning

confidence: 99%

“…AUASI questionnaire includes seven questions to query the presence of a possible irritative (frequency, urgency, and nocturia) and obstructive (incomplete emptying, decrease in flow rate, and straining) urinary symptoms. A scoring system was utilized to classify the degree of the symptoms as mild (0-7), moderate (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19), or severe (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). The final item of the AUASI form investigates the impact of urinary symptoms on QoL, and this entity is scored between 0 and 6 (10).…”

Section: Methodsmentioning

confidence: 99%

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Frequency of Lower Urinary Tract Symptoms and Effects on Quality of Life in Women with Rheumatoid Arthritis

Aras¹,

Aras²,

İçağasıoğlu³

et al. 2015

Turk J Phys Med Rehab

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Objective: To investigate the frequency of lower urinary tract symptoms (LUTS) in women with rheumatoid arthritis (RA) and to evaluate its possible effects on quality of life (QoL). Material and Methods: A total of 104 women diagnosed with RA, who were aged between 30 and 60 years, and 82 healthy women were included in this study. We used the American Urological Association symptom index as the gold criteria in the evaluation of LUTS and QoL. Hospital Anxiety and Depression Scale was used to evaluate anxiety/depression levels, whereas disease activity scale (DAS-28) and Health Assessment Questionnaire (HAQ) were used to determine the disease activity levels. Results: There was no statistical difference between the two groups by means of age range. There was a prominent difference in LUTS frequency between the groups and moderate to severe symptoms were higher in women with RA. QoL measurements were also significantly lower in this group (p<0.01). There was a positive relationship between anxiety and LUTS and significantly positive relationship between depression and LUTS measurement (p<0.01). There was a positive relationship between depression and QoL; however, there was no relationship between anxiety and QoL measurements. Although there was no relationship between LUTS and DAS-28, significant relationship was found between LUTS and HAQ. There was no relationship between QoL and DAS-28; however, there was a significant relationship between QoL and HAQ (p<0.01). Conclusion: LUTS were more frequent in women with RA; furthermore, QoL was low. Furthermore, these symptoms can be related with anxiety and depression. Moderate and severe symptoms observed in women with RA are frequently related with HAQ.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Frequency of Lower Urinary Tract Symptoms and Effects on Quality of Life in Women with Rheumatoid Arthritis

Aras¹,

Aras²,

İçağasıoğlu³

et al. 2015

Turk J Phys Med Rehab

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“…LUTS suggestive of BPH are common in ageing men and are associated with a reduced quality of life (QoL) [1]. Numerous studies have reported a high prevalence of BPH, which affects ≈ 40% of men aged > 50 years [2], with differences between countries [3], and its relationship with age [4].…”

Section: Introductionmentioning

confidence: 99%

Profile and management of patients treated for the first time for lower urinary tract symptoms/benign prostatic hyperplasia in four European countries

Fourcade¹,

Théret²,

Taïeb³

2008

BJU International

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OBJECTIVETo describe the profile and management of patients medically treated for benign prostatic hyperplasia (BPH) in primary care in four European countries, as the diagnosis and management of BPH have developed dramatically in the last decade, and recent information from actual practice is insufficient.PATIENTS AND METHODSThis observational, cross‐sectional study was carried out by general practitioners in France (141 patients), Spain (127) and Portugal (50), and by office‐based urologists in Germany (162 patients) between July 2005 and June 2006. The physicians were unaware of the study sponsor. Patients aged ≥50 years were recruited if a decision for medical treatment of BPH was taken for the first time on that day. The patient and the investigator had to complete one questionnaire each.RESULTSThe physicians included 480 patients, with a mean (sd) age of 65.0 (7.8) years. The mean (sd) International Prostate Symptom Score (IPSS) was 16.0 (7.3). There were geographical differences in age (P = 0.009; patients in Germany being the youngest), IPSS (P = 0.017; patients in Spain having the highest score), quality of life (QoL; IPSS item 8, P < 0.001, the least altered being in Germany), and sexual activity (P = 0.010; the highest proportion of sexually active patients being in Portugal), but not for comorbidities and concomitant medication. The IPSS correlated poorly with age (r = 0.21) and moderately with QoL (r = 0.47). Severe symptoms (IPSS > 19) were not linked with sexual activity (age‐adjusted P = 0.378). Serum prostate specific antigen testing, although not recommended for BPH, was widely used (83.8% overall). All other examinations were carried out disparately depending on the country (P < 0.001 each). Digital rectal examination (DRE) and excluding urinary tract infection (urine culture) were used in ≈75% of study patients, but only half the patients in France had a urine culture, and 52% in Portugal had a DRE. A standardized assessment of symptoms and/or QoL was reported in 45% of study patients, with wide discrepancies among countries, i.e. 77.2% in Germany and 6.0% in Portugal. α‐blocker monotherapy was the most frequently prescribed treatment (62.5% overall, 87.1% in Germany, 46.1% in France), followed by phytotherapy (23.5%), and 5α‐reductase inhibitor monotherapy (3.75%); combinations were rare. Treatment varied according to the severity of the symptoms (P = 0.008), phytotherapy being given to patients with the lowest IPSS, and combinations to those with the highest IPSS.CONCLUSIONThere were geographical discrepancies that could be attributed to either different cultural habits or merely organisational differences, e.g. the presence of office urologists in Germany or diverse modes of access to phytotherapy (prescription vs ‘over the counter’) in the various countries.

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“…4 BPH can induce acute urinary retention, incontinence, recurrent urinary tract infection or obstructive uropathy. LUTS secondary to BPH generally consists of three components: benign proliferation of the stroma and epithelium, bladder outlet obstruction and symptoms resulting from obstruction.…”

Section: Introductionmentioning

confidence: 99%

Nerve growth factor signaling following unilateral pelvic ganglionectomy in the rat ventral prostate is age dependent

Podlasek

Ghosh²,

Çakır³

et al. 2013

Asian J Androl

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Benign prostatic hyperplasia (BPH) is a serious health concern and is an underlying cause of lower urinary tract symptoms (LUTS) in many men. In affected men, LUTS/BPH is believed to result from benign proliferation of the prostate resulting in bladder outlet obstruction. Postnatal growth of the prostate is controlled via growth factor and endocrine mechanisms. However, little attention had been given to the function of the autonomic nervous system in prostate growth and differentiation. Nerve growth factor (NGF) is a prostatic mitogen that has a trophic role in autonomic sensory end organ interaction. In this study, we examine how the autonomic nervous system influences prostate growth as a function of age by quantifying NGF in the rat ventral prostate (VP) after pelvic ganglionectomy. Unilateral pelvic ganglionectomy was performed on postnatal days 30 (P30), 60 and 120 Sprague-Dawley rats in comparison to sham controls (n539). Semiquantitative RT-PCR, Western blotting and immunohistochemical analysis for NGF were performed on denervated, intact (contralateral side) and sham control VP 7 days after surgery. Ngf RNA expression was significantly increased in the denervated and intact hyperplastic VP. Western blotting showed age-dependent increases in NGF protein at P60 in the contralateral intact VP. NGF was localized in the nerves, basal cells and columnar epithelium of the prostatic ducts. Denervation causes age-dependent increases in NGF in the VP, which is a potential mechanism by which the autonomic nervous system may regulate prostate growth and lead to BPH/LUTS. Asian Journal of Andrology (2013) Keywords: denervation; nerve growth factor; prostate growth; ventral prostate INTRODUCTION Benign prostatic hyperplasia (BPH) is a serious health concern worldwide and is an underlying cause of many lower urinary tract symptoms (LUTS). LUTS is common in aging men and a population based survey performed in five countries reports that ,64% of adults experience at least one LUTS symptom.1 LUTS has a profound impact on social functioning and quality of life in affected men 2,3 with similar effects reported as after a heart attack or stroke.4 BPH can induce acute urinary retention, incontinence, recurrent urinary tract infection or obstructive uropathy. LUTS secondary to BPH generally consists of three components: benign proliferation of the stroma and epithelium, bladder outlet obstruction and symptoms resulting from obstruction.

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The impact of lower urinary tract symptoms and comorbidities on quality of life: the BACH and UREPIK studies

Cited by 145 publications

References 21 publications

Frequency of Lower Urinary Tract Symptoms and Effects on Quality of Life in Women with Rheumatoid Arthritis

Frequency of Lower Urinary Tract Symptoms and Effects on Quality of Life in Women with Rheumatoid Arthritis

Profile and management of patients treated for the first time for lower urinary tract symptoms/benign prostatic hyperplasia in four European countries

Nerve growth factor signaling following unilateral pelvic ganglionectomy in the rat ventral prostate is age dependent

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