The Impact of Marijuana Use on Glucose, Insulin, and Insulin Resistance among US Adults

Penner, Elizabeth; Buettner, Hannah; Mittleman, Murray A.

doi:10.1016/j.amjmed.2013.03.002

Cited by 172 publications

(171 citation statements)

References 16 publications

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“…[49][50][51][52] A recently published study also demonstrated that current marijuana use was associated with lower levels of fasting insulin, lower homeostasis model assessmentestimated insulin resistance, and smaller waist circumference. 53 Two recently published review articles on medical marijuana for digestive disorders and select neurologic disorders generally noted small numbers of studies and mixed results. 54,55 There are no published studies on the use of cannabinoids or marijuana to treat health conditions in children or adolescents.…”

Section: Research Findings On Pharmaceutical Cannabinoids and Medicalmentioning

confidence: 99%

The Impact of Marijuana Policies on Youth: Clinical, Research, and Legal Update

Levy¹,

Ammerman²,

Gonzalez³

et al. 2015

Pediatrics

158

112

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This technical report updates the 2004 American Academy of Pediatrics technical report on the legalization of marijuana. Current epidemiology of marijuana use is presented, as are definitions and biology of marijuana compounds, side effects of marijuana use, and effects of use on adolescent brain development. Issues concerning medical marijuana specifically are also addressed. Concerning legalization of marijuana, 4 different approaches in the United States are discussed: legalization of marijuana solely for medical purposes, decriminalization of recreational use of marijuana, legalization of recreational use of marijuana, and criminal prosecution of recreational (and medical) use of marijuana. These approaches are compared, and the latest available data are presented to aid in forming public policy. The effects on youth of criminal penalties for marijuana use and possession are also addressed, as are the effects or potential effects of the other 3 policy approaches on adolescent marijuana use. Recommendations are included in the accompanying policy statement.

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Section: Research Findings On Pharmaceutical Cannabinoids and Medicalmentioning

confidence: 99%

The Impact of Marijuana Policies on Youth: Clinical, Research, and Legal Update

Levy¹,

Ammerman²,

Gonzalez³

et al. 2015

Pediatrics

158

112

View full text Add to dashboard Cite

show abstract

“…There is some evidence for this, but results are inconsistent. Multiple studies have reported in Cannabis users reduced rates of diabetes mellitus, insulin insensitivity, or metabolic syndrome in fully adjusted models including age (Rajavashisth et al, 2012, Ngueta et al, 2015, Alshaarawy and Anthony, 2015, Penner et al, 2013, Thompson and Hay, 2015, Waterreus et al, 2016. Yankey et al (Yankey et al, 2016) also reported decreased DM rates (AOR 0.42) that did not reach statistical significance (95% CI = 0.13 -1.36).…”

Section: Observations Supporting This Theorymentioning

confidence: 92%

Theoretical Explanation for Reduced Body Mass Index and Obesity Rates in <em>Cannabis</em> Users

Clark

Jones

Hall

et al. 2018

Preprint

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Abstract:Obesity is treatment-resistant, and is linked with a number of serious, chronic diseases. Adult obesity rates in the United States have tripled since the early 1960s. Recent reviews show that an increased ratio of omega-6 to omega-3 fatty acids contributes to obesity rates by increasing levels of the endocannabinoid signals AEA and 2-AG, overstimulating CB1R and leading to increased caloric intake, reduced metabolic rates, and weight gain. Cannabis, or THC, also stimulates CB1R and increases caloric intake during acute exposures. The present meta-analysis reveals significantly reduced body mass index and rates of obesity in Cannabis users, in conjunction with increased caloric intake. We provide for the first time a causative explanation for this paradox, in which rapid and long-lasting downregulation of CB1R following acute Cannabis consumption reduces energy intake and storage and increases metabolic rates, thus reversing the impact on body mass index of elevated dietary omega-6/omega-3 ratios.Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted:

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“…Past marijuana users have odds ratio of 0.44 (95% CI 0.33 to 0.59) and current heavy users have odds ratio of 0.47 (95% CI 0.22 to 0.98) then non-marijuana users, Figure 2. Later in 2013, Mittleman and coworkers [26] analyzed data from the National Health and Nutrition Examination Survey (NHANES) including 4657 adult men and women from 2005 and 2010. They reported that the correlation between marijuana use and lower fasting insulin level and less insulin resistant is statistically significant, Table 2.…”

Section: 2epidemiological Studies That Link Cannabinoid and Decreasmentioning

confidence: 99%

Is Marijuana Beneficial for Prevention and Treatment of Diabetes?

Cao¹,

Wang²,

Zhang³

et al. 2017

Am. J. Biomed. Sci.

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Marijuana is classified as Cannabis saiva L, one type of hemp. Traditionally, Marijuana is considered as Schedule I drug due to its acute bad effects on human health. However, its medical use has been widely recognized today. Delta-9-tetrahydrocannabinol ( 9 -THC) is a compound extracted from Marijuana, which has been used in several drugs approved by United States Food and Drug Administration (FDA).  9 -THC functions through cannabinoid receptor in neural system or peripheral tissues. For diabetes patients,  9 -THC has been reported to have preventative or treatment effects. In this paper, we will review recent research progress in association between cannabis use and diabetes, as well as known mechanism of how  9 -THC functions in human from the perspective of free radicals.

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The Impact of Marijuana Use on Glucose, Insulin, and Insulin Resistance among US Adults

Cited by 172 publications

References 16 publications

The Impact of Marijuana Policies on Youth: Clinical, Research, and Legal Update

The Impact of Marijuana Policies on Youth: Clinical, Research, and Legal Update

Theoretical Explanation for Reduced Body Mass Index and Obesity Rates in <em>Cannabis</em> Users

Is Marijuana Beneficial for Prevention and Treatment of Diabetes?

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