The impact of mastication on cognition: Evidence for intervention and the role of adult hippocampal neurogenesis

Smith, Natalie; Miquel-Kergoat, Sophie; Thuret, Sandrine

doi:10.3233/nua-150054

Cited by 9 publications

(7 citation statements)

References 43 publications

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“…Brain-derived neurotrophic factor (BDNF) and its receptor, tyrosine kinase receptor B (TrkB; encoded by the Ntrk2 gene), promote neuronal cell proliferation, differentiation, survival, and synapse formation (Vicario-Abejón et al 2002;Lu 2003). Masticatory dysfunction downregulates the BDNF pathway, resulting in the reduction in the number of neuronal progenitor cells and functional neurons (Smith et al 2016). These together suggest the linkage between BDNF/TrkB signaling and masticatory dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Reduced Mastication Impairs Memory Function

et al. 2017

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Mastication is an indispensable oral function related to physical, mental, and social health throughout life. The elderly tend to have a masticatory dysfunction due to tooth loss and fragility in the masticatory muscles with aging, potentially resulting in impaired cognitive function. Masticatory stimulation has influence on the development of the central nervous system (CNS) as well as the growth of maxillofacial tissue in children. Although the relationship between mastication and cognitive function is potentially important in the growth period, the cellular and molecular mechanisms have not been sufficiently elucidated. Here, we show that the reduced mastication resulted in impaired spatial memory and learning function owing to the morphological change and decreased activity in the hippocampus. We used an in vivo model for reduced masticatory stimuli, in which juvenile mice were fed with powder diet and found that masticatory stimulation during the growth period positively regulated long-term spatial memory to promote cognitive function. The functional linkage between mastication and brain was validated by the decrease in neurons, neurogenesis, neuronal activity, and brain-derived neurotrophic factor (BDNF) expression in the hippocampus. These findings taken together provide in vivo evidence for a functional linkage between mastication and cognitive function in the growth period, suggesting a need for novel therapeutic strategies in masticatory function-related cognitive dysfunction.

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Section: Introductionmentioning

confidence: 99%

Reduced Mastication Impairs Memory Function

et al. 2017

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“…Apart from the above, there are pathological changes in peridontal tissues and uncontrolled bone losses as well as destruction of temporomandibular joint structures, strain, and development of chewing muscles. This in turn does not remain without any influence on certain cognitive functions coordinated by certain brain structures [42]. Mediating function in this case is fulfilled by brain-derived neurotrophic factor (BDNF) as well as its receptor, TrkB, dysfunctions within chewing organ enhancing lowering of progenitor cells level (kind of stem cell used for regeneration process) and functional neurons as a result of action of BDNF tracts removal from adjustment [43].…”

Section: Psycho-neurophysiological Mechanisms In Chewing Organs Disormentioning

confidence: 99%

Changes in cognitive functioning as an effect of complex treatment of myofascial pain in temporomandibular disorders

Biegańska-Banaś¹,

Pihut²,

Gierowski³

et al. 2018

jos

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Introduction: Pain reduction is a benefit that comprehensive treatment of myalgic temporomandibular disorders can provide. Myalgic pain reduction is associated with a series of changes at the neurophysiological level, which are inseparably connected with psychoemotional and cognitive changes. It has not been established if the course of these changes is the same for chronic myofascial pain in temporomanibular disorders as it is for other types of chronic pain. Objectives: The present study examined changes in cognitive functioning among patients with myofascial pain before and after three months of prosthetic treatment supplemented with psychoeducational and physiotherapeutic therapy. Material and methods: Participants were 45 patients, 23 were people with painful myofascial temporomandibular disorders and 22 were people with disorders of the same type who did not complain about pain symptoms. Statistical analysis included group comparisons of verbal learning, perceptiveness, attention, verbal fluency, immediate and working memory as well as selected executive functions measured with a number of psychological tests and neuropsychological clinical trials. Results: Analyses based on two-sided dependent samples t-tests as well as the Fisher's LSD tests conducted in the analysis of variances showed therapeutic effects, both, with reference to chosen spheres of cognitive functioning, which initially differentiated the control and research groups, as well as the ones which did not differentiate these two groups. Conclusions: The results of this study indicate that cognitive functioning undergoes dynamic changes in the initial phase of treatment. Some of these changes may be specific for myofascial pain. The awareness about those changes may appear to be essential for planning therapeutic procedures and beneficial to maintain patient's engagement in the process of treatment.

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“…Epidemiologic studies have suggested associations between cognitive ability and oral conditions, such as number of teeth (Luo et al, 2015;Li et al, 2017;Oh et al, 2018) and dental occlusion (Ono et al, 2010;Franco et al, 2012;Takeuchi et al, 2015). Furthermore, occlusal force (Takeshita et al, 2016;Ikebe et al, 2018) and chewing ability have been shown to have effects on cognitive ability (Chen et al, 2015;Natalie et al, 2015;Seraj et al, 2017). Oral reconstruction by means of wearing a denture may induce cortical activation in prefrontal, sensorimotor, and sensory association cortices during chewing performance (Kimoto et al, 2011;Kamiya et al, 2016) and might also contribute to antiaging cognitive activation in the prefrontal cortex of elderly edentulous patients (Banu et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Prefrontal Consolidation and Compensation as a Function of Wearing Denture in Partially Edentulous Elderly Patients

Narita

Ishii

Iwaki

et al. 2020

Front. Aging Neurosci.

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Background: The cognitive effects of wearing a denture are not well understood. This study was conducted to clarify the effects of denture use on prefrontal and chewing muscle activities, occlusal state, and subjective chewing ability in partially edentulous elderly individuals.Methods: A total of 16 partially edentulous patients were enrolled. Chewing-related prefrontal cortex and jaw muscle activities were simultaneously examined using a functional near-infrared spectroscopy (fNIRS) device and electromyography, under the conditions of unwearing, and wearing a denture. Occlusal state and masticatory score were also determined under both conditions. Using multiple linear regression analysis, associations between prefrontal and chewing activities with wearing were examined using change rates.Results: Chewing rhythmicity was maintained under both conditions. As compared with unwearing, the wearing condition was associated with improved prefrontal cortex and chewing muscle activities, occlusal state in regard to force and area, and masticatory score. Also, prefrontal activities were positively associated with burst duration and peak amplitude in masseter (Mm) and temporal muscle activities, as well as masticatory scores. In contrast, prefrontal activities were negatively associated with occlusal force. Conclusion:Wearing a denture induced a positive association between burst duration and peak amplitude in Mm and temporal muscle activities and prefrontal activity, which may indicate a parallel consolidation of prefrontal cortex and rhythmical chewing activities, as well as masticatory scores. On the other hand, denture use induced a negative association of occlusal force with prefrontal activities, which might suggest that prefrontal compensative associations for the physiocognitive acquisition depended on biomechanical efficacy gained by wearing a denture.

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The impact of mastication on cognition: Evidence for intervention and the role of adult hippocampal neurogenesis

Cited by 9 publications

References 43 publications

Reduced Mastication Impairs Memory Function

Reduced Mastication Impairs Memory Function

Changes in cognitive functioning as an effect of complex treatment of myofascial pain in temporomandibular disorders

Prefrontal Consolidation and Compensation as a Function of Wearing Denture in Partially Edentulous Elderly Patients

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