The impact of maternal obesity on completion of fetal anomaly screening

Eastwood, Kelly‐Ann; Daly, Ciara; Hunter, Alyson; McCance, David R.; Holmes, Valerie

doi:10.1515/jpm-2016-0048

Cited by 17 publications

(16 citation statements)

References 14 publications

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“…Maternal obesity might affect fetal neurodevelopment through multiple pathways. Maternal obesity has an impact on fetal anomaly screening[ 38 ] and birth defects[ 39 ]. Maternal obesity is associated with neurodevelopmental and psychiatric disorders in offspring[ 40 – 44 ] via related alterations in the uterine environment[ 25 ] and/or epigenetic processes[ 26 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Association between maternal overweight or obesity and cerebral palsy in children: A meta-analysis

Xiao

Huang

et al. 2018

PLoS ONE

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ContextThere is no consensus regarding the association between maternal obesity or overweight and cerebral palsy (CP) in children.ObjectivesTo investigate whether maternal obesity or overweight is associated with CP and identify the factors that explain the differences in the study results.Data sourcesWe conducted a meta-analysis of studies published in English with titles or abstracts that discussed the relationships between maternal obesity or overweight and CP before August 23, 2017, using Ovid Medline, EMBASE and Web of Science.Study selectionOf 2699 initially identified studies, 8 studies that addressed the association between maternal obesity and CP met our final inclusion criteria.Data extractionInformation from the individual studies was abstracted using standardized forms by 2 independent observers who were blinded to the authors’ names and journal titles.Data synthesisAccording to a random effects model, maternal overweight was significantly associated with CP in offspring [RR = 1.29 (95% CI, 1.04–1.60), heterogeneity (I2 = 45.5%, P = 0.103)]; maternal obesity was significantly associated with CP in offspring [RR = 1.45 (95% CI, 1.25–1.69), heterogeneity (I2 = 24.1%, P = 0.253)]; and maternal obesity III was significantly associated with CP in offspring [RR = 2.25 (95% CI, 1.82–2.79), heterogeneity (I2 = 0%, P = 0.589)]. However, maternal underweight was not significantly associated with CP in offspring [RR = 1.11 (95% CI, 0.88–1.38), low heterogeneity (I2 = 0%, P = 0.435)]. Factors that explained the differences in the meta-analysis results included study design, study location, and whether individual studies adjusted for potential confounders.ConclusionThis study suggests that maternal obesity and overweight increase the risk of CP in offspring. Further studies are required to confirm these results and determine the influence of variables across studies.

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Section: Discussionmentioning

confidence: 99%

Association between maternal overweight or obesity and cerebral palsy in children: A meta-analysis

Xiao

Huang

et al. 2018

PLoS ONE

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“…Obesity impacts scan completion and image quality, which can affect the detection of fetal anomalies 99,100 . Women with obesity should be made aware that some forms of screening may less effective with a raised BMI 37,46,101,102 …”

Section: Figo Guidance For Pregnancy Obesitymentioning

confidence: 99%

Management of prepregnancy, pregnancy, and postpartum obesity from the FIGO Pregnancy and Non‐Communicable Diseases Committee: A FIGO (International Federation of Gynecology and Obstetrics) guideline

McAuliffe

Killeen

Jacob

et al. 2020

Intl J Gynecology & Obste

114

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Obstetricians and gynecologists are well positioned to influence population health through maternity and women's health services. Obesity is common in women of reproductive age and the prevalence is rising in both low-/middle-income and high-income countries 1. Obesity affects requirements for assessment, monitoring, and intervention and can impact maternal and child outcomes. Obstetricians and gynecologists require guidance on the care of women of reproductive age with obesity at all time points related to pregnancy, including how to address modifiable risk factors such as diet and physical activity. Many guidelines have been developed to date, although they vary in scope, methodology, and individual recommendations. FIGO's Committee Guideline for the Management of Prepregnancy, Pregnancy, and Postpartum Obesity (Table 1) reviews good clinical practice recommendations (Table 2-4) from previously published international documents. It serves as a practical resource to support obstetricians and gynecologists in the management of This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…Since we offered FP beyond 17 weeks' gestation, we enrolled women who underwent medical abortions after this threshold. Exclusion criteria were [1] surgical abortion (dilatation and evacuation), [2] medical abortion without an identified treatment protocol, [3] FP via intra-amniotic digoxin injection (IADI), [4] diagnosis of fetal death before FP, and [5] multiple pregnancies. Written informed consent on the termination of pregnancy and the possible risks of any procedures was obtained from participating women.…”

Section: Methodsmentioning

confidence: 99%

“…The study population was divided into 2 based on the implementation of FP prior to misoprostol administration: [1] with FP and [2] without FP. Groups were compared in terms of maternal age, body mass index, gravidity, parity, previous medical history of uterine operations, GA at DOI: 10.1159/000491085 abortion, medical indication for induced abortion, I-to-A interval, prolonged abortion rate, maternal side effects, and duration of hospitalization.…”

Section: Methodsmentioning

confidence: 99%

“…Ultrasound anatomy scan, in conjunction with genetic tests such as fetal karyotyping, aims to detect either fetal abnormalities incompatible with life or those that may benefit from early interventions [1]. The incidence of major structural abnormalities (MSAs) in a low-risk population is around 1.5% with a wide range of antenatal detection rate [2].…”

Section: Introductionmentioning

confidence: 99%

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The Utility of Feticide Procedure to Shorten the Induction-to-Abortion Interval in Medical Abortion

Akkurt

Yavuz

et al. 2018

Gynecol Obstet Invest

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Aim: To evaluate the effect of intracardiac potassium chloride feticide procedure (FP) on the induction-to-abortion (I-to-A) interval for various indications in the termination of pregnancy. Method: Medically indicated abortions between 17 and 28 weeks’ gestation were retrospectively evaluated and allocated into 2 groups: Cases with (group 1, n = 58) or without an FP (group 2, n = 60). I-to-A intervals were compared across the groups, considering different baseline parameters and fetal abnormality categories. Results: There were no differences among the groups except in gestational age (GA; mean, 21.2 vs. 19.6 weeks, p = 0.01) in group 1. Overall, the I-to-A interval was shorter (900 ± 233 vs. 1,198 ± 375 min, p = 0.001) and prolonged medical abortion (I-to-A interval > 48 h) was less common (2% vs. 6%, p = 0.03) in group 1. The facilitating effect of FP persisted when indications were categorized as central nervous system, chromosomal, other structural abnormalities, and unclassified conditions. Logistic regression analyses demonstrated the following features to be associated with expulsion of fetus after 24-h: (1) advanced GA (> 24 week; aOR 6.9, 95% CI 3.24–14.72), (2) central nervous system abnormalities (aOR 5.3, 95% CI 2.6–11.4), (3) lack of feticide (aOR 3.67, 95% CI 2.24–10.72). Conclusion: FPs seem to shorten the I-to-A interval and decrease prolonged I-to-A interval rates. This facilitating effect remains unchanged for various medical indications.

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The impact of maternal obesity on completion of fetal anomaly screening

Abstract: Maternal obesity has a significant impact on completion of fetal anomaly screening.

Cited by 17 publications

References 14 publications

Association between maternal overweight or obesity and cerebral palsy in children: A meta-analysis

Association between maternal overweight or obesity and cerebral palsy in children: A meta-analysis

Management of prepregnancy, pregnancy, and postpartum obesity from the FIGO Pregnancy and Non‐Communicable Diseases Committee: A FIGO (International Federation of Gynecology and Obstetrics) guideline

The Utility of Feticide Procedure to Shorten the Induction-to-Abortion Interval in Medical Abortion

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