The Impact of Mechanical Forces in Heart Morphogenesis

Granados-Riveron, Javier T; Brook, David

doi:10.1161/circgenetics.111.961086

Cited by 75 publications

(57 citation statements)

References 113 publications

(108 reference statements)

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“…In addition, endothelial and endocardial cells experience radial wall pressure due to hydrostatic pressure and this causes stretching of the cells. These biophysical forces change dynamically as the heart grows during development and as the strength and efficiency of the heart beat increases (Culver and Dickinson, 2010;Granados-Riveron and Brook, 2012). Thus, compared with other vascular beds, endocardial cells experience unique biophysical forces and forms of mechanical stress beyond fluid flow, including stretching during the diastole and contraction during the systole of each cardiac contractile cycle (Mickoleit et al, 2014).…”

Section: Hemodynamic Forces and Cardiac Morphogenesis: The Role Of Thmentioning

confidence: 99%

The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis

Haack

Abdelilah‐Seyfried

2016

Development

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Endocardial cells are cardiac endothelial cells that line the interior of the heart tube. Historically, their contribution to cardiac development has mainly been considered from a morphological perspective. However, recent studies have begun to define novel instructive roles of the endocardium, as a sensor and signal transducer of biophysical forces induced by blood flow, and as an angiocrine signalling centre that is involved in myocardial cellular morphogenesis, regeneration and reprogramming. In this Review, we discuss how the endocardium develops, how endocardial-myocardial interactions influence the developing embryonic heart, and how the dysregulation of blood flowresponsive endocardial signalling can result in pathophysiological changes.

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Section: Hemodynamic Forces and Cardiac Morphogenesis: The Role Of Thmentioning

confidence: 99%

The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis

Haack

Abdelilah‐Seyfried

2016

Development

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“…A potential influence on tissue architecture and the orientation of cell division (Kada et al, 1999) is hemodynamics. Blood flow is a later determinant of heart shape and myofiber architecture (Granados-Riveron and Brook, 2012). However, during embryonic heart development, blood flow is progressively established (Nishii and Shibata, 2006), which would explain why the fetal heart is more organized.…”

Section: Research Articlementioning

confidence: 99%

Quantitative analysis of polarity in 3D reveals local cell coordination in the embryonic mouse heart

et al. 2013

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Anisotropies that underlie organ morphogenesis have been quantified in 2D, taking advantage of a reference axis. However, morphogenesis is a 3D process and it remains a challenge to analyze cell polarities in 3D. Here, we have designed a novel procedure that integrates multidisciplinary tools, including image segmentation, statistical analyses, axial clustering and correlation analysis. The result is a sensitive and unbiased assessment of the significant alignment of cell orientations in 3D, compared with a random axial distribution. Taking the mouse heart as a model, we validate the procedure at the fetal stage, when cardiomyocytes are known to be aligned. At the embryonic stage, our study reveals that ventricular cells are already coordinated locally. The centrosome-nucleus axes and the cell division axes are biased in a plane parallel to the outer surface of the heart, with a minor transmural component. We show further alignment of these axes locally in the plane of the heart surface. Our method is generally applicable to other sets of vectors or axes in 3D tissues to map the regions where they show significant alignment.

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“…In embryos, the electrical activity of the heart affects cardiac development, from a linear heart tube to a four-chambered heart. It has been shown that electrical activity can play a role in early development both directly [1] and indirectly via changes to myocardial contraction [2,3]. Additionally, electrical activity can be altered by molecular and mechanical changes [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown that electrical activity can play a role in early development both directly [1] and indirectly via changes to myocardial contraction [2,3]. Additionally, electrical activity can be altered by molecular and mechanical changes [3,4]. Abnormal electrical activity may lead to congenital heart defects [5,6], one of the most common types of birth defects that affects over 32,000 live births in the United States each year, with a quarter of those affected requiring invasive surgery during the first year after birth [7].…”

Section: Introductionmentioning

confidence: 99%

Optical stimulation enables paced electrophysiological studies in embryonic hearts

Wang

et al. 2014

Biomed. Opt. Express

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Cardiac electrophysiology plays a critical role in the development and function of the heart. Studies of early embryonic electrical activity have lacked a viable point stimulation technique to pace in vitro samples. Here, optical pacing by high-precision infrared stimulation is used to pace excised embryonic hearts, allowing electrophysiological parameters to be quantified during pacing at varying rates with optical mapping. Combined optical pacing and optical mapping enables electrophysiological studies in embryos under more physiological conditions and at varying heart rates, allowing detection of abnormal conduction and comparisons between normal and pathological electrical activity during development in various models. 440-447 (1978). 12. K. Kamino, "Optical approaches to ontogeny of electrical activity and related functional organization during early heart development," Physiol. Rev. 71(1), 53-91 (1991 Macrae, and D. S. Rosenbaum, "The zebrafish as a novel animal model to study the molecular mechanisms of mechano-electrical feedback in the heart," Prog. Biophys. Mol. Biol. 110(2-3), 154-165 (2012). 18. M. Bressan, G. Liu, and T. Mikawa, "Early mesodermal cues assign avian cardiac pacemaker fate potential in a tertiary heart field," Science 340 (

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The Impact of Mechanical Forces in Heart Morphogenesis

Cited by 75 publications

References 113 publications

The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis

The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis

Quantitative analysis of polarity in 3D reveals local cell coordination in the embryonic mouse heart

Optical stimulation enables paced electrophysiological studies in embryonic hearts

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