The impact of medical therapy on cognitive dysfunction in chronic rhinosinusitis

Rowan, Nicholas R.; Schlosser, Rodney J.; Storck, Kristina A.; Ganjaei, Kimia G.; Soler, Zachary M.

doi:10.1002/alr.22323

Cited by 16 publications

(30 citation statements)

References 50 publications

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“…Additionally, CRS patients had worse simple reaction time scores compared to controls on computerized neurocognitive testing, a difference that persisted regardless of polyp status. Since this initial report, several studies have found improvements in patient‐reported and objective cognitive function after both medical and surgical treatment of CRS 75–77 …”

Section: General Concepts Of Rhinosinusitismentioning

confidence: 98%

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International consensus statement on allergy and rhinology: rhinosinusitis 2021

Orlandi

Kingdom

Smith

et al. 2021

Int Forum Allergy Rhinol

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518

479

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I. Executive Summary Background The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS.

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Section: General Concepts Of Rhinosinusitismentioning

confidence: 98%

“…A case‐control study found that patients with CRS report significantly worse scores on the Cognitive Failures Questionnaire as compared with controls 74 . Several subsequent studies have found improvements in patient‐reported and objective cognitive function after both medical and surgical treatment of CRS 75–77 …”

Section: Introductionmentioning

confidence: 99%

International consensus statement on allergy and rhinology: rhinosinusitis 2021

Orlandi

Kingdom

Smith

et al. 2021

Int Forum Allergy Rhinol

Self Cite

518

479

View full text Add to dashboard Cite

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“…The current review encompassed 4 studies utilizing the FSS in patients with CRS, with a mean of 4.2, suggesting problematic fatigue for this subgroup. Taken together, these subjective parameters are suggestive of poor sleep; however, it is also possible that other disease factors, such as the patient's heightened inflammatory state, 33 sinonasal‐specific symptoms, or altered cognition, 2,43 may be responsible for changes in sleep‐related PROMs, independent of one's actual sleep quality. Evidently, the mechanisms in which these diseases may lead to sleep dysfunction are complex and likely multifactorial.…”

Section: Discussionmentioning

confidence: 99%

Rhinologic disease and its impact on sleep: a systematic review

Fried

Yuen

et al. 2020

Int Forum Allergy Rhinol

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Background Rhinologic disease can be responsible for systemic symptoms affecting mood, cognition, and sleep. It is unclear whether sleep disturbance in specific rhinologic disorders (chronic rhinosinusitis [CRS], rhinitis, and nasal septal deviation [NSD]) is an obstructive phenomenon or due to other mechanisms. In this review we examine the impact of CRS, rhinitis, and NSD on objective and subjective sleep outcome metrics and draw comparisons to normal controls and patients with known obstructive sleep apnea (OSA). Methods A systematic review of 4 databases (PubMed, Scopus, Cochrane Library, and Web of Science) was performed. Studies reporting on objective (apnea‐hypopnea index [AHI], respiratory disturbance index [RDI], oxygen nadir) and subjective (Epworth Sleepiness Scale [EpSS], Pittsburgh Sleep Quality Index [PSQI], Fatigue Severity Scale [FSS]) sleep parameters and disease‐specific patient‐reported outcome measures (PROMs; 22‐item Sino‐Nasal Outcome Test [SNOT‐22], Rhinoconjunctivitis Quality of Life Questionnaire [RQLQ], Nasal Obstruction Symptom Evaluation [NOSE]) were included. Results The database search yielded 1414 unique articles, of which 103 were included for analysis. Baseline PROMs were at the high end of normal to abnormal for all 3 conditions: EpSS: CRS (9.8 ± 4.0), rhinitis (9.7 ± 4.3), and NSD (8.9 ± 4.6); and PSQI: CRS (11.0 ± 4.5), rhinitis (6.1 ± 3.7), and NSD (8.6 ± 3.5). Objective measures demonstrated a mild to moderate OSA in the studied diseases: AHI: CRS (10.4 ± 11.5), rhinitis (8.6 ± 8.8), and NSD (13.0 ± 6.9). There were significant differences when compared with reported norms in all measured outcomes (p < 0.001). Conclusion Sleep quality is impacted by rhinologic (CRS, rhinitis, NSD) disease. There is likely a mild obstructive component contributing to poor sleep, but other contributing factors may be involved.

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“…A prospective study in the US reported that appropriate medical therapy improved several measures of cognitive dysfunction in patients with CRS. [ 25 ] In addition, in a multicenter study, patients with CRS with nasal polyps reported significant improvements in cognitive scores after endoscopic sinus surgery. [ 26 ] The declines in inflammation and cytokines following medical treatment or surgery may be 1 factor driving improvements in cognition.…”

Section: Discussionmentioning

confidence: 99%

Association between neurodegenerative dementia and chronic rhinosinusitis

et al. 2020

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The aim of this case-control study was to evaluate the association between chronic rhinosinusitis (CRS) and neurodegenerative dementia in a large representative Korean population. The ≥ 50-year-old population was selected from the Korean Health Insurance Review and Assessment Service – National Sample Cohort from 2002 to 2015. A total of 17,634 neurodegenerative dementia patients were matched in a 1:4 ratio with 70,536 control participants for age, sex, income, and region of residence. Neurodegenerative dementia was defined using the ICD-10 codes G30 and F00. CRS was identified based on the ICD-10 code J32. Among the cohort, we selected participants who were treated ≥ 2 times and those who underwent head and neck computed tomography. The odds ratio (OR) for CRS in patients with dementia was analyzed using a conditional logistic regression model. Subgroup analyses were conducted according to age and sex. There was no difference in the prevalence of CRS with/without nasal polyps between the dementia (1.1%) and control (1.2%) groups ( P = .825). CRS with/without nasal polyps was not significantly associated with dementia (adjusted OR = 0.96, 95% CI = 0.82–1.13, P = .653). In the subgroup analyses according to age and sex, the adjusted ORs for CRS with/without nasal polyps were not higher in the dementia group than in the control group. Previous CRS was not associated with neurodegenerative dementia in the Korean population.

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The impact of medical therapy on cognitive dysfunction in chronic rhinosinusitis

Cited by 16 publications

References 50 publications

International consensus statement on allergy and rhinology: rhinosinusitis 2021

International consensus statement on allergy and rhinology: rhinosinusitis 2021

Rhinologic disease and its impact on sleep: a systematic review

Association between neurodegenerative dementia and chronic rhinosinusitis

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