The Impact of Memory Change on Daily Life in Normal Aging and Mild Cognitive Impairment

Parikh, Preeyam K.; Troyer, Angela K.; Maione, Andrea; Murphy, Kelly J.

doi:10.1093/geront/gnv030

Cited by 101 publications

(91 citation statements)

References 28 publications

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“…Avoidant coping was also a key observation of the qualitative study of 14 individuals with amnestic MCI reported by Parikh et al 30 These individuals reported withdrawing from the social activities they previously enjoyed to avoid embarrassment and frustration when their memory fails them in these settings. Social exclusion was also reported, such as being interrupted when they hesitate in conversations, and feeling that their friends no longer share information with them in the way they had previously.…”

Section: Phenomenology Of MCImentioning

confidence: 93%

State of the science on mild cognitive impairment (MCI)

2019

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Mild cognitive impairment (MCI) represents a transitional stage between healthy aging and dementia, and affects 10–15% of the population over the age of 65. The failure of drug trials in Alzheimer’s disease (AD) treatment has shifted researchers’ focus toward delaying progression from MCI to dementia, which would reduce the prevalence and costs of dementia profoundly. Diagnostic criteria for MCI increasingly emphasize the need for positive biomarkers to detect preclinical AD. The phenomenology of MCI comprises lower quality-of-life, greater symptoms of depression, and avoidant coping strategies including withdrawal from social engagement. Neurobiological features of MCI are hypoperfusion and hypometabolism in temporoparietal cortices, medial temporal lobe atrophy particularly in rhinal cortices, elevated tau and phosphorylated tau and decreased Aβ42 in cerebrospinal fluid, and brain Aβ42 deposition. Elevated tau can be identified in MCI, particularly in the entorhinal cortex, using positron emission tomography, and analysis of signal complexity using electroencephalography or magnetoencephalography holds promise as a biomarker. Assessment of MCI also relies on cognitive screening and neuropsychological assessment, but there is an urgent need for standardized cognitive tests to capitalize on recent discoveries in cognitive neuroscience that may lead to more sensitive measures of MCI. Cholinesterase inhibitors are frequently prescribed for MCI, despite the lack of evidence for their efficacy. Exercise and diet interventions hold promise for increasing reserve in MCI, and group psychoeducational programs teaching practical memory strategies appear effective. More work is needed to better understand the phenomenology and neurobiology of MCI, and how best to assess it and delay progression to dementia.

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Section: Phenomenology Of MCImentioning

confidence: 93%

State of the science on mild cognitive impairment (MCI)

2019

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“…Changes in cognitive ability affect the lives of elderly people. However, the extent of this impact has been reported to be more significant and more negative in those with mild cognitive impairment (MCI) that is not serious enough to interfere with everyday activities [1]. Moreover, individuals with MCI are at an increased risk of developing Alzheimer's [2] or other forms of dementia [3].…”

Section: Introductionmentioning

confidence: 99%

Frequent Karaoke Training Improves Frontal Executive Cognitive Skills, Tongue Pressure, and Respiratory Function in Elderly People: Pilot Study from a Randomized Controlled Trial

Miyazaki¹,

Mori²

2020

IJERPH

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We tested whether karaoke training improves cognitive skills and reduces the risk of physical function impairments. We conducted a single-blinded randomized controlled trial in 26 elderly participants at residential care facilities, who were generally healthy or required the lowest level of care. Participants were near the threshold for mild cognitive impairment with the Montreal Cognitive Assessment (MoCA) and close to the sarcopenia cut-off with the skeletal muscle mass index. Pulmonary function as measured with spirometry and tongue strength were used as markers for physical functions affected by sarcopenia. Karaoke training occurred once a week for two hours, with an hour of homework assigned weekly. Karaoke training significantly improved the Frontal Assessment Battery at bedside (FAB) compared with an active control group receiving scratch art training (F = 8.04, permutation p-value = 0.013). Subscore improved with inhibitory control (F = 7.63, permutation p-value = 0.015) and sensitivity to interference (F = 11.98, permutation p-value = 0.001). We observed improved tongue pressure (F = 4.49, permutation p-value = 0.040) and pulmonary function by a greater increase in FIV1 (F = 5.22, permutation p-value = 0.047). Engaging elderly people, especially those in care homes, with karaoke training exercises that are moderately physically challenging may be a key to slowing cognitive decline and preventing dysphagia by sarcopenia.

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“…This is a particular problem for older adults with amnestic mild cognitive impairment (aMCI), which is characterized by explicit memory deficits greater than expected according to one's age (Albert et al, 2011;Petersen, 2004), and is a likely precursor to dementia due to Alzheimer's disease (AD). As explicit memory begins to decline, people with aMCI are vulnerable to withdrawal from social and leisure activities in part because of potential embarrassment around forgetting the names of friends and acquaintances (Parikh, Troyer, Maione, & Murphy, 2016).…”

Section: Introductionmentioning

confidence: 99%

An Incidental Learning Method to Improve Face-Name Memory in Older Adults With Amnestic Mild Cognitive Impairment

Biss

Rowe

Hasher

et al. 2020

J Int Neuropsychol Soc

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Objective: Forgetting names is a common memory concern for people with amnestic mild cognitive impairment (aMCI) and is related to explicit memory deficits and pathological changes in the medial temporal lobes at the early stages of Alzheimer’s disease (AD). In the current experiment, we tested a unique method to improve memory for face–name associations in people with aMCI involving incidental rehearsal of face–name pairs. Method: Older adults with aMCI and age- and education-matched controls learned 24 face–name pairs and were tested via immediate cued recall with faces as cues for associated names. During a 25- to 30-min retention interval, 10 of the face–name pairs reappeared as a quarter of the items on a seemingly unrelated 1-back task on faces, with the superimposed names irrelevant to the task. After the delay, surprise delayed cued recall and forced-choice associative recognition tests were administered for the face–name pairs. Results: Both groups showed reduced forgetting of the names that repeated as distraction and enhanced recollection of these pairs. Conclusions: The results demonstrate that passive methods to prompt automatic retrieval of associations may hold promise as interventions for people with early signs of AD.

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The Impact of Memory Change on Daily Life in Normal Aging and Mild Cognitive Impairment

Cited by 101 publications

References 28 publications

State of the science on mild cognitive impairment (MCI)

State of the science on mild cognitive impairment (MCI)

Frequent Karaoke Training Improves Frontal Executive Cognitive Skills, Tongue Pressure, and Respiratory Function in Elderly People: Pilot Study from a Randomized Controlled Trial

An Incidental Learning Method to Improve Face-Name Memory in Older Adults With Amnestic Mild Cognitive Impairment

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