The impact of menopause on functional status in women with rheumatoid arthritis

Mollard, Elizabeth; Pedro, Sofia; Chakravarty, Eliza; Clowse, Megan E.B.; Schumacher, Rebecca; Michaud, Kaleb

doi:10.1093/rheumatology/kex526

Cited by 31 publications

(24 citation statements)

References 12 publications

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“…25 In a recent study of 8,000 women of varying ages, the view that the hormonal changes of menopause worsen the symptoms of rheumatoid arthritis and contribute to functional physical decline has been endorsed as regards complaints of joint pain, a relationship between estrogen levels and changes in joint inflammation, although the mechanisms of this association are not yet well defined. 26 However, the high prevalence of these painful complaints in this study can be related to previously undiagnosed sickle cell anemia (SCA). It is known that SCA is a hereditary disease caused by a mutated hemoglobin linked to the progeny of populations originating, mainly, in sub-Saharan Africa, and that may present clinical manifestation of chronic or acute pain, intense or not, and chronic organic tissue damage and progression due to venous stasis and hypoxia.…”

Section: Resultsmentioning

confidence: 70%

Perfil das mulheres no climatério residentes em uma comunidade quilombola

Tavares

Almeida

Abrão

et al. 2018

Rev enferm UFPE on line.

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RESUMOObjetivo: identificar o perfil socioeconômico, demográfico, clínico e hábitos de vida de mulheres no climatério residentes em uma comunidade quilombola. Método: trata-se de um estudo quantitativo, descritivo, de corte transversal, desenvolvido em uma comunidade quilombola. Utilizou-se um questionário padronizado com 158 participantes. Construiu-se um banco de dados em planilha eletrônica sendo calculadas as frequências absolutas e relativas, e os resultados apresentam-se em forma de tabelas. Resultados: observou-se que a maioria das mulheres era parda, com companheiro estável e renda familiar de até dois salários mínimos. Apontou-se que um terço não tinha nenhuma escolaridade, e um quarto das menopausadas teve a sua última menstruação entre 38 e 42 anos. Ressalta-se que mais de um terço das pesquisadas portava doença crônica e, dessas, a quase totalidade era hipertensa, com ou sem diabetes associada. Conclusão: identificaram-se, neste estudo, as características de um grupo de mulheres no climatério de uma comunidade quilombola, sendo que a escassez de pesquisas sobre essas comunidades, no que se refere aos dados investigados, torna a pesquisa original e relevante. Descritores: Saúde da Mulher; Climatério; Menopausa; Grupo com Ancestrais do Continente Africano; População; Qualidade de Vida.ABSTRACT Objective: to identify the socioeconomic, demographic, clinical profile and life habits of climateric women living in a quilombola community. Method: This is a quantitative, descriptive, cross-sectional study developed in a quilombola community. A standardized questionnaire was used with 158 participants. A database was built in spreadsheet and the absolute and relative frequencies were calculated, and the results are presented in the form of tables. Results: it was observed that the majority of the women were brown, with stable companion and family income of up to two minimum salaries. It was pointed out that a third had no schooling, and a quarter of the menopause had its last menstruation between 38 and 42 years. It is noteworthy that more than a third of those surveyed had chronic disease, of which almost all were hypertensive, with or without associated diabetes. Conclusion: In this study, we identified the characteristics of a group of women in the climacteric of a quilombola community, and the lack of research on these communities, regarding the data investigated, makes the research original and relevant.Descriptors: Women's Health; Climacteric period; Menopause; Group with Ancestors of the African Continent; Population; Quality of life. RESUMEN Objetivo: identificar el perfil socioeconómico, demográfico, clínico y hábitos de vida de las mujeres en el climaterio, residentes en una comunidad cimarrona. Método: se trata de un estudio cuantitativo, descriptivo, de corte transversal, desarrollado en una comunidad cimarrona. Se utilizó un cuestionario estandarizado con 158 participantes. Se construyó una base de datos en hoja de cálculo y se calcularon las frecuencias absolutas y relativas, y los resultados se presentan en forma de tablas. Resultados: se observó que la mayoría de las mujeres eran pardas, con un compañero estable e ingresos familiares de hasta dos salarios mínimos. Se apunta que un tercio no tenía ninguna escolaridad, y un cuarto de las menopáusicas tuvo su última menstruación entre 38 y 42 años. Se resalta que más de un tercio de las investigadas portaba enfermedad crónica y, de esas, la casi totalidad era hipertensa, con o sin diabetes asociada. Conclusión: se identificaron, en este estudio, las características de un grupo de mujeres en el climaterio de una comunidad cimarrona, siendo que la escasez de investigaciones sobre esas comunidades, en lo que se refiere a los datos investigados, hace la investigación original y relevante. Descriptores: Salud de la Mujer; Climaterio; Menopausia; Grupo de Ascendencia Continental Africana; Población; Calidad de Vida.

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Section: Resultsmentioning

confidence: 70%

Perfil das mulheres no climatério residentes em uma comunidade quilombola

Tavares

Almeida

Abrão

et al. 2018

Rev enferm UFPE on line.

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“…Moreover, the levels of single coagulation factors increase, while the levels of natural anticoagulants decline with menopause in healthy women [30]. Regarding RA, the risk for disease onset is associated with an earlier age at menopause [31], and the postmenopausal period is related to higher disease activity and more rapid progression of disability [32,33].…”

Section: Discussionmentioning

confidence: 99%

Assessment of hemostatic disturbances in women with established rheumatoid arthritis

et al. 2019

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Objectives This study was aimed to assess hemostatic disturbances in female patients with established rheumatoid arthritis (RA) in relation to menopausal status and disease activity. Method Ninety women were included in the study, 42 patients and 48 age-matched healthy controls. There were no differences between the investigated groups regarding the presence of traditional cardiovascular risk factors. Two global hemostatic assays were employed, namely endogenous thrombin potential (ETP) and overall hemostasis potential (OHP). The parameters of the ETP assay (ETP, C-max, t-lag, t-max) and OHP assay (overall coagulation potential (OCP) and overall fibrinolytic potential (OFP)) were assessed. Moreover, the parameters of the fibrin clot (lag time, Max Abs, and slope) were measured by clot turbidity and scanning electron microscopy (SEM). Both patients and controls were divided into four subgroups according to menopause status. Results The premenopausal controls differed significantly from all other subgroups in terms of diminished levels of ETP (p = 0.02), C-max (p = 0.01), OCP (p = 0.02), OHP (p = 0.001), and Max Abs (p = 0.008), while OFP (p = 0.0001) was increased. This tendency was not seen in the premenopausal RA patients compared with the postmenopausal RA patients. SEM images showed denser clots composed of thinner fibers in samples from RA patients. The disease activity measured by DAS28 correlated with OCP and OHP (r = 0.54; p = 0.001 and r = 0.44; p = 0.003, respectively) indicating persistent hypercoagulable condition in the whole group of RA patients. Conclusions Our results point towards coagulation activation in premenopausal women with established RA. The patients were well characterized, which enabled assessment in a real-life setting. Key Points • Extensive assessment points towards persistent coagulation activation in premenopausal women with established rheumatoid arthritis. • Impaired thrombin generation and fibrin formation are associated with menopause in healthy women, while rheumatoid arthritis closes the gap within patients regarding menopause. • Fibrin morphology is unfavorably altered and fibrinolysis is decreased in patients with established rheumatoid arthritis. • Increased activity of thrombin activatable fibrinolysis inhibitor (TAFI) may contribute to impaired fibrinolysis in patients with rheumatoid arthritis.

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“…IL-1β is one of the most critical proinflammatory cytokines related to the pathogenesis of rheumatoid arthritis [9]. Like the previous studies, Mollard et al also linked lower hormone levels during menopause to the advancement of rheumatoid arthritis [10]. To corroborate their claim, the researchers compared functional status in premenopausal and postmenopausal women with rheumatoid arthritis [10].…”

Section: Relationship Between Rheumatoid Arthritis and Menopausementioning

confidence: 90%

“…Like the previous studies, Mollard et al also linked lower hormone levels during menopause to the advancement of rheumatoid arthritis [10]. To corroborate their claim, the researchers compared functional status in premenopausal and postmenopausal women with rheumatoid arthritis [10]. A Health Assessment Questionnaire (HAQ) was used to measure the functional status of premenopausal versus postmenopausal women who had rheumatoid arthritis [10].…”

Section: Relationship Between Rheumatoid Arthritis and Menopausementioning

confidence: 93%

Do Menopause and Aging Affect the Onset and Progression of Rheumatoid Arthritis and Systemic Lupus Erythematosus?

Shah

Elshaikh

Lee

et al. 2020

Cureus

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Rheumatoid arthritis and systemic lupus erythematosus (SLE) are autoimmune diseases that are commonly seen in the female population. Rheumatoid arthritis mainly consists of distal symmetrical deforming polyarthritis. SLE patients have immune complexes that damage the organs and systems of the body, and this can present with one or more symptoms including the characteristic malar rash, serositis, lupus nephritis, photosensitivity, and arthritis of large joints. The onset and progression of the diseases are affected by physiological processes that occur in the body such as menopause and aging. The studies used as evidence were found in the PubMed, ScienceDirect, ProQuest, Taylor & Francis Online, Wiley Online Library, Ovid, and Oxford Academic databases. By analyzing these studies, the effects of aging and menopause on rheumatoid arthritis and SLE were revealed. In relation to menopause and aging, it was found that there was a progression of disease in women who had rheumatoid arthritis. However, aging and menopause caused the progression of SLE to decrease in women. An earlier age of onset of menopause was correlated with an increased chance of developing rheumatoid arthritis and SLE. Furthermore, while some studies showed that a later onset of SLE caused an increase in the progression of the disease, other studies showed that a later onset of SLE led to a decrease in the progression of the disease. Due to the prevalence of rheumatoid arthritis and SLE in females, we believe that the effects of menopause, age, and other factors on these two diseases should be examined in future studies.

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The impact of menopause on functional status in women with rheumatoid arthritis

Cited by 31 publications

References 12 publications

Perfil das mulheres no climatério residentes em uma comunidade quilombola

Perfil das mulheres no climatério residentes em uma comunidade quilombola

Assessment of hemostatic disturbances in women with established rheumatoid arthritis

Do Menopause and Aging Affect the Onset and Progression of Rheumatoid Arthritis and Systemic Lupus Erythematosus?

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