The Impact of Mesenchymal Stem Cell Source on Proliferation, Differentiation, Immunomodulation and Therapeutic Efficacy

Cheng, Hui

doi:10.4172/2157-7633.1000237

Cited by 22 publications

(27 citation statements)

References 100 publications

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“…Although the potential has been shown to differ between MSCs from different tissue sources, MSCs fundamentally have the same set of abilities of secreting trophic, angiogenic, and immunomodulatory signals. 14–16 The ability of immunomodulation is of special interest for this review.…”

Section: Mesenchymal Stromal/stem Cellsmentioning

confidence: 99%

Increased Paracrine Immunomodulatory Potential of Mesenchymal Stromal Cells in Three-Dimensional Culture

Follin

Juhl

CohenSmadar

et al. 2016

Tissue Engineering Part B: Reviews

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Mesenchymal stromal/stem cells (MSCs) have been investigated extensively through the past years, proving to have great clinical therapeutic potential. In vitro cultivation of MSCs in three-dimensional (3D) culture systems, such as scaffolds, hydrogels, or spheroids, have recently gained attention for tissue engineering applications. Studies on MSC spheroids demonstrated that such cultivation increased the paracrine immunomodulatory potential of the MSCs, accompanied by phenotypic alterations. In this review, we gather results from recent experimental studies on the immunomodulatory abilities of MSCs when cultured as spheroids or in biomaterials like scaffolds or hydrogels compared to regular two-dimensional (2D) culture and show that alterations occurring to MSCs in spheroids also occur in MSCs in biomaterials. We provide a brief description of known mechanisms of MSC immunomodulatory capacity and how they are altered in the two 3D culture systems, together with phenotypic cellular changes. Based on the present knowledge, we highlight vital areas in need of further investigation. The impact of 3D environments on immunomodulation has great potential for tissue engineering and cellular therapy, and this is the first review to gather this knowledge with a comparison across different 3D environments.

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Section: Mesenchymal Stromal/stem Cellsmentioning

confidence: 99%

Increased Paracrine Immunomodulatory Potential of Mesenchymal Stromal Cells in Three-Dimensional Culture

Follin

Juhl

CohenSmadar

et al. 2016

Tissue Engineering Part B: Reviews

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“…To compare i MSC1255 with other metabolic network models, three tissue specific metabolic models (‘adipose’, ‘blood’ and ‘bone marrow’) were chosen. Adipose, bone marrow, and also peripheral blood, are the main sources for isolating MSCs . Thus, we needed to show that our BMMSC metabolic network model was not included in metabolic networks of these tissues.…”

Section: Resultsmentioning

confidence: 99%

Reconstruction and validation of a constraint‐based metabolic network model for bone marrow‐derived mesenchymal stem cells

2015

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“…AT 7,9,10,12,13,30 • Adipocytes • Chondrocytes • Osteocytes • Muscle cells Isolated from liposuction, lipoplasty or lipectomy materials • This source results in the isolation of up to 500 times more stem cells than BM (i.e. 5 × 10 3 cells from 1 g of AT).…”

Section: • Generation Of Pancreatic Cells In Vitromentioning

confidence: 99%

Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art review

Berebichez-Fridman

Montero-Olvera

2018

Sultan Qaboos Univ Med J

343

211

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First discovered by Friedenstein in 1976, mesenchymal stem cells (MSCs) are adult stem cells found throughout the body that share a fixed set of characteristics. Discovered initially in the bone marrow, this cell source is considered the gold standard for clinical research, although various other sources—including adipose tissue, dental pulp, mobilised peripheral blood and birth-derived tissues—have since been identified. Although similar, MSCs derived from different sources possess distinct characteristics, advantages and disadvantages, including their differentiation potential and proliferation capacity, which influence their applicability. Hence, they may be used for specific clinical applications in the fields of regenerative medicine and tissue engineering. This review article summarises current knowledge regarding the various sources, characteristics and therapeutic applications of MSCs.Keywords: Mesenchymal Stem Cells; Adult Stem Cells; Regenerative Medicine; Cell Differentiation; Tissue Engineering.

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The Impact of Mesenchymal Stem Cell Source on Proliferation, Differentiation, Immunomodulation and Therapeutic Efficacy

Cited by 22 publications

References 100 publications

Increased Paracrine Immunomodulatory Potential of Mesenchymal Stromal Cells in Three-Dimensional Culture

Increased Paracrine Immunomodulatory Potential of Mesenchymal Stromal Cells in Three-Dimensional Culture

Reconstruction and validation of a constraint‐based metabolic network model for bone marrow‐derived mesenchymal stem cells

Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art review

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