The impact of metabolic syndrome components on urinary parameters and risk of stone formation

Bamberger, Jacob; Rosen, Daniel; Khusid, Johnathan A.; Kaplan-Marans, Elie; Gallante, Blair; Kapoor, Arjun; Paranjpe, Ishan; Atashsokhan, Danie J; Atallah, William; Gupta, Mantu

doi:10.1007/s00345-021-03790-7

Cited by 8 publications

(3 citation statements)

References 17 publications

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“…In stone formers, a negative correlation between BMI and urinary pH has been reported in both men and women [ 7 ]. Moreover, a recent study of stone formers indicated that all components of the metabolic syndrome except hyperlipidemia were independently associated with low urinary pH suggesting a mechanism independent from insulin resistance [ 47 ]. In the present study, the prevalence of metabolic syndrome did not differ between the two groups at either time point.…”

Section: Discussionmentioning

confidence: 99%

Effect of Two Different Dietary Weight Loss Strategies on Risk Factors for Urinary Stone Formation and Cardiometabolic Risk Profile in Overweight Women

Siener

Ernsten

Bitterlich³

et al. 2022

Nutrients

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Overweight has been suggested to increase the risk of kidney stone formation. Although weight reduction might affect risk factors for urolithiasis, findings on the impact of different dietary weight loss strategies are limited. This randomized, controlled study evaluated the effect of a conventional energy-restricted modified diet with (MR group) or without meal replacement (C group) on risk factors for stone formation in overweight women without a history of urolithiasis. Of 105 participants, 78 were included into the per-protocol analysis. Anthropometric, clinical, biochemical, and 24 h urinary parameters were collected at baseline and after 12 weeks. Although both dietary interventions resulted in a significant weight reduction, relative weight loss and rate of responders were higher in the MR group. Weight loss improved cardiometabolic risk profile in both groups. Unfortunately, the benefit of decreased GPT activity in the C group was offset by a significant increase in homocysteine and a decline in GFR. While the relative supersaturation of calcium oxalate decreased significantly in both groups, a significant decline in serum uric acid concentration and relative supersaturation of uric acid was observed only in the MR group. Finally, the energy-restricted modified diet with meal replacement showed significant advantages over the energy-restricted modified diet alone.

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Section: Discussionmentioning

confidence: 99%

Effect of Two Different Dietary Weight Loss Strategies on Risk Factors for Urinary Stone Formation and Cardiometabolic Risk Profile in Overweight Women

Siener

Ernsten

Bitterlich³

et al. 2022

Nutrients

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“…There was a higher MetS prevalence in men than in women when the MSSS was 1-4, but the opposite was true when the MSSS was equal to 5. The sex distribution was also found to be significantly different between the groups (MSSS 0 = 51.7% male, MSSS 1 = 46.9% male, MSSS 2 = 62.5% male, MSSS 3 = 57.9% male, MSSS 4 = 72.2% male, and MSSS 5 = 52.6% male; p = 0.039) in another study ( 20 ). The group in the low-income tier represented a greater proportion than the group with high income when the MSSS≥2, unlike men, which was similar to the findings of Kim H ( 21 ) and Drewnowski A ( 22 ).…”

Section: Discussionmentioning

confidence: 83%

The prevalence and clustering of metabolic syndrome risk components in Chinese population: a cross-sectional study

Zhao,

Lu,

Song

et al. 2023

Front. Endocrinol.

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ObjectiveThe metabolic syndrome (MetS) is diagnosed upon the manifestation of ≥ 3 out of 5 specific components. The present study evaluated the epidemiological characteristics of the MetS components and their clustering condition among Chinese adults.Methods68383 participants aged 18-80 years from TIDE were scored on a six-point (0–5) MetS severity score (MSSS), which quantified their cumulative amount of MetS risk components. We evaluated the epidemiological characteristics of these components and their clustering conditions. Additionally, we examined the relation of age with the prevalence of different MSSSs or specific MetS components using restricted cubic splines.ResultsAmong 68383 participants, 26113 men and 24582 women had abnormal MetS components. There were significant differences in most epidemiological characteristics between the 6 MSSS groups. The top three prevalence of abnormal metabolic components were high systolic blood pressure (SBP) (9.41%, n=6568), high waist circumference (WC) (8.13%, n=6120), and the cooccurrence of high SBP and high WC (6.33%, n=4622). Participants were more likely to have all five MetS components when HDL-C was low. Restricted cubic splines showed that when the MSSS ≥3, the MetS prevalence of male peaked and that of the female population increased most rapidly at 40-60 age group.ConclusionThe 40-60 age group can be regarded as the high-risk period of MetS, and elderly women have a higher risk of multiple metabolic disorders than men. The top three clustering of abnormal metabolic components were high SBP, high WC, and their combination. Multiple components aggregation was more likely to occur when HDL-C decreased.

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“…Persistent over-acidification plays a decisive role in this regard. Epidemiologic studies have shown that metabolic syndrome is strongly associated with UAS due to various metabolic and environmental factors promoting insulin resistance and stone formation within urine samples (Abou-Elela 2017 ; Bamberger et al 2021 ; Xiao et al 2020 ). Stone patients who are obese or diabetic tend to have higher proportions of total stones consisting of UAS compared to those who possess normal body mass indices (BMI) or serum glucose levels (Daudon et al 2006a , 2006b ).…”

Section: Introductionmentioning

confidence: 99%

Potassium sodium hydrogen citrate intervention on gut microbiota and clinical features in uric acid stone patients

Cao,

Li,

Ding

et al. 2024

Appl Microbiol Biotechnol

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The high recurrence rate of renal uric acid stone (UAS) poses a significant challenge for urologists, and potassium sodium hydrogen citrate (PSHC) has been proven to be an effective oral dissolution drug. However, no studies have investigated the impact of PSHC on gut microbiota and its metabolites during stone dissolution therapy. We prospectively recruited 37 UAS patients and 40 healthy subjects, of which 12 patients completed a 3-month pharmacological intervention. Fasting vein blood was extracted and mid-stream urine was retained for biochemical testing. Fecal samples were collected for 16S ribosomal RNA (rRNA) gene sequencing and short chain fatty acids (SCFAs) content determination. UAS patients exhibited comorbidities such as obesity, hypertension, gout, and dyslipidemia. The richness and diversity of the gut microbiota were significantly decreased in UAS patients, Bacteroides and Fusobacterium were dominant genera while Subdoligranulum and Bifidobacterium were poorly enriched. After PSHC intervention, there was a significant reduction in stone size accompanied by decreased serum uric acid and increased urinary pH levels. The abundance of pathogenic bacterium Fusobacterium was significantly downregulated following the intervention, whereas there was an upregulation observed in SCFA-producing bacteria Lachnoclostridium and Parasutterella, leading to a significant elevation in butyric acid content. Functions related to fatty acid synthesis and amino acid metabolism within the microbiota showed upregulation following PSHC intervention. The correlation analysis revealed a positive association between stone pathogenic bacteria abundance and clinical factors for stone formation, while a negative correlation with SCFAs contents. Our preliminary study revealed that alterations in gut microbiota and metabolites were the crucial physiological adaptation to PSHC intervention. Targeted regulation of microbiota and SCFA holds promise for enhancing drug therapy efficacy and preventing stone recurrence. Key points • Bacteroides and Fusobacterium were identified as dominant genera for UAS patients • After PSHC intervention, Fusobacterium decreased and butyric acid content increased • The microbiota increased capacity for fatty acid synthesis after PSHC intervention

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The impact of metabolic syndrome components on urinary parameters and risk of stone formation

Cited by 8 publications

References 17 publications

Effect of Two Different Dietary Weight Loss Strategies on Risk Factors for Urinary Stone Formation and Cardiometabolic Risk Profile in Overweight Women

Effect of Two Different Dietary Weight Loss Strategies on Risk Factors for Urinary Stone Formation and Cardiometabolic Risk Profile in Overweight Women

The prevalence and clustering of metabolic syndrome risk components in Chinese population: a cross-sectional study

Potassium sodium hydrogen citrate intervention on gut microbiota and clinical features in uric acid stone patients

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