The impact of MOFs in pH-dependent drug delivery systems: progress in the last decade

De, Diptiman; Sahoo, Prithidipa

doi:10.1039/d2dt00994c

Cited by 27 publications

(9 citation statements)

References 111 publications

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“…The pH responsiveness of MOFs used for siRNA delivery is a critical property that significantly enhances the specificity and efficiency of therapeutic delivery. 85 This responsiveness is intricately linked to the unique structural characteristics of MOFs, particularly their coordination bonds. 86 Coordination bonds are the chemical links between metal ions (nodes) and organic ligands (linkers) that form the three-dimensional structure of MOFs.…”

Section: Mof Nanocarriersmentioning

confidence: 99%

A biomimetic camouflaged metal organic framework for enhanced siRNA delivery in the tumor environment

Tao,

Rehman,

et al. 2024

J. Mater. Chem. B

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Section: Mof Nanocarriersmentioning

confidence: 99%

A biomimetic camouflaged metal organic framework for enhanced siRNA delivery in the tumor environment

Tao,

Rehman,

et al. 2024

J. Mater. Chem. B

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“…The porosity, loading capacity, release kinetics, biocompatibility, and toxicity of MOFs may also be impacted by these tactics. Hence, for each application, a careful balance between stability and functionality needs to be struck [ 171 ].…”

Section: Challenge Of Mof Nanomaterials In Cancer Treatmentmentioning

confidence: 99%

Utilization of Functionalized Metal–Organic Framework Nanoparticle as Targeted Drug Delivery System for Cancer Therapy

Tran

Doan

et al. 2023

Pharmaceutics

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Cancer is a multifaceted disease that results from the complex interaction between genetic and environmental factors. Cancer is a mortal disease with the biggest clinical, societal, and economic burden. Research on better methods of the detection, diagnosis, and treatment of cancer is crucial. Recent advancements in material science have led to the development of metal–organic frameworks, also known as MOFs. MOFs have recently been established as promising and adaptable delivery platforms and target vehicles for cancer therapy. These MOFs have been constructed in a fashion that offers them the capability of drug release that is stimuli-responsive. This feature has the potential to be exploited for cancer therapy that is externally led. This review presents an in-depth summary of the research that has been conducted to date in the field of MOF-based nanoplatforms for cancer therapeutics.

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“…In addition to the above materials, other MOFs have been designed and prepared successfully as drug carriers to improve the therapeutic efficacy [141][142][143][144][145][146][147][148][149][150][151][152][153][154][155][156][157][158]. Similar with the Fe-MOFs, UiOs, and CD-MOFs, other MOFs are constructed by metal ions/clusters (Zn 2+ , Cu 2+ , and Bi 3+ ) and bridging linkers.…”

Section: Other Mofsmentioning

confidence: 99%

Recent Advances in Metal–Organic-Framework-Based Nanocarriers for Controllable Drug Delivery and Release

et al. 2022

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Metal–organic frameworks (MOFs) have a good designability, a well-defined pore, stimulus responsiveness, a high surface area, and a controllable morphology. Up to now, various MOFs have been widely used as nanocarriers and have attracted lots of attention in the field of drug delivery and release because of their good biocompatibility and high-drug-loading capacity. Herein, we provide a comprehensive summary of MOF-based nanocarriers for drug delivery and release over the last five years. Meanwhile, some representative examples are highlighted in detail according to four categories, including the University of Oslo MOFs, Fe-MOFs, cyclodextrin MOFs, and other MOFs. Moreover, the opportunities and challenges of MOF-based smart delivery vehicles are discussed. We hope that this review will be helpful for researchers to understand the recent developments and challenges of MOF-based drug-delivery systems.

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The impact of MOFs in pH-dependent drug delivery systems: progress in the last decade

Abstract: Metal-organic frameworks (MOFs) are porous crystalline materials of one-, two-, or three-dimensional networks manufactured from metal ions/clusters and multidentate organic linkers through coordination bonding. MOFs are one of the most...

Cited by 27 publications

References 111 publications

A biomimetic camouflaged metal organic framework for enhanced siRNA delivery in the tumor environment

A biomimetic camouflaged metal organic framework for enhanced siRNA delivery in the tumor environment

Utilization of Functionalized Metal–Organic Framework Nanoparticle as Targeted Drug Delivery System for Cancer Therapy

Recent Advances in Metal–Organic-Framework-Based Nanocarriers for Controllable Drug Delivery and Release

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