The impact of music therapy on anxiety and pregnancy rate among infertile women undergoing assisted reproductive technologies: a systematic review and meta-analysis

Mahmoud, Marwa Yahia; Labib, Kareem; Sileem, Sileem Ahmed; Mustafa, Ali; Hamed, Waleed; El-Hamid, A. A. Abd; Saleh, Doaa M; Alanwar, Ahmed; Riad, Amr Ahmed Mahmoud; Abdelhakim, Ahmed Mohamed; Abbas, Ahmed M.; Mohammed, Heba M.

doi:10.1080/0167482x.2021.1977277

Cited by 5 publications

(1 citation statement)

References 30 publications

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“…Despite that anxiety before treatment could not be viewed as a direct drawback for infertility treatment, given the high prevalence of the disease and dysregulation of cortisol secretion, evaluation and intervention of the psychological and physiological issues of anxiety are preferred. Some relaxation methods such as music therapy could be recommended, and patients with severe symptoms can be referred to a psychologist ( 45 , 46 ). With the convenience of sampling and the POCT method, morning serum cortisol measurement could be a feasible approach to promote the primary evaluation of anxiety and related endocrine dysregulations among infertile women.…”

Section: Discussionmentioning

confidence: 99%

Cortisol dysregulation in anxiety infertile women and the influence on IVF treatment outcome

Chai

Wang

et al. 2023

Front. Endocrinol.

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IntroductionDysregulation of the stress-regulatory hormone cortisol is associated with anxiety, but its potential impact on infertile women and in vitro fertilization (IVF) treatment remains unclear. This prospective cross-sectional study aimed at evaluating the dysregulation of cortisol and its correlation to anxiety in infertile women. The influence of stress on IVF outcomes was also investigated.MethodsA point-of-care test was used for the measurement of morning serum cortisol in 110 infertile women and 112 age-matching healthy individuals. A Self-Rating Anxiety Scale (SAS) was used for the anxiety assessment of infertile women, and 109 of them underwent IVF treatment starting with the GnRH-antagonist protocol. If clinical pregnancy was not achieved, more IVF cycles were conducted with adjusted protocols until the patients got pregnant or gave up.ResultsHigher morning serum cortisol level was identified for infertile patients, especially for the elder. Women with no anxiety showed significant differences in cortisol levels, monthly income, and BMI compared with those with severe anxiety. A strong correlation was found between the morning cortisol level and the SAS score. When the cutoff value is 22.25 μg/dL, cortisol concentration could predict the onset of anxiety with high accuracy (95.45%) among infertile women. After IVF treatments, women with high SAS scores (>50) or cortisol levels (>22.25 μg/dL) demonstrated a lower rate of pregnancy (8.0%-10.3%) and more IVF cycles, although the impact of anxiety was not affirmative.ConclusionHypersecretion of cortisol related to anxiety was prevalent among infertile women, but the influence of anxiety on multi-cycle IVF treatment was not affirmative due to the complicated treatment procedures. This study suggested that the assessment of psychological disorders and stress hormone dysregulation should not be overlooked. An anxiety questionnaire and rapid cortisol test might be included in the treatment protocol to provide better medical care.

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Section: Discussionmentioning

confidence: 99%

Cortisol dysregulation in anxiety infertile women and the influence on IVF treatment outcome

Chai

Wang

et al. 2023

Front. Endocrinol.

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Use of Laughter Therapy for In Vitro Fertilization: A Systematic Review

Rodríguez-García,

Rodríguez-Suárez,

González-de la Torre

2024

Reprod. Med.

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Background/Objectives: In vitro fertilization (IVF) is an assisted reproductive technique for women and couples experiencing difficulties in achieving a spontaneous pregnancy, often due to stressors that negatively affect fertility. Humor can be beneficial in these stressful situations, helping to reduce symptoms of anxiety and depression. The primary aim was to analyze the effectiveness of laughter therapy in increasing pregnancy rates in women undergoing IVF. The secondary aims were to identify different types of laughter therapy interventions and evaluate their benefits. Methods: A systematic review was conducted using Medline, Web of Science, Scopus, Cinahl, ProQuest and Lilacs, with the search terms “laughter”, “laughter therapy”, “fertilization in vitro” and “fertilization”. Intervention studies published in English, Spanish, or Portuguese were included, with no limits on the date of publication. Studies with other designs, those conducted with animals and grey literature were excluded. The quality of the included studies was assessed using the Joanna Briggs Institute critical appraisal tools. Results: In total, n = 3 studies (1 randomized clinical trial and 2 quasi-experimental) were included, evaluating pregnancy rates and symptoms of depression and anxiety. The interventions included clowns performing magic tricks and interpreting comic situations. Additionally, they incorporated hand clapping, breathing exercises, childlike playfulness, drinking milk, muscle relaxation exercises, candles, and music. Conclusions: This review does not provide clear evidence on the effectiveness of laughter therapy in increasing pregnancy success in IVF. Although it may have some positive effects in reducing symptoms of depression and anxiety, it is important to note that while the reduction of these symptoms may enhance the emotional well-being of patients, it has not been demonstrated to directly lead to an increase in pregnancy rates. Laughter therapy is an innovative, non-pharmacological intervention that is simple, non-invasive, easy to implement and cost-effective; however, the number of available studies is insufficient. More research is needed to provide better and higher-quality evidence using rigorous designs to evaluate this intervention in IVF clinical practice.

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Impact of psychological stress on ovarian function: Insights, mechanisms and intervention strategies (Review)

Hu,

Wang,

et al. 2024

Int J Mol Med

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The impact of music therapy on anxiety and pregnancy rate among infertile women undergoing assisted reproductive technologies: a systematic review and meta-analysis

Cited by 5 publications

References 30 publications

Cortisol dysregulation in anxiety infertile women and the influence on IVF treatment outcome

Cortisol dysregulation in anxiety infertile women and the influence on IVF treatment outcome

Use of Laughter Therapy for In Vitro Fertilization: A Systematic Review

Impact of psychological stress on ovarian function: Insights, mechanisms and intervention strategies (Review)

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