The Impact of New-Onset Postoperative Atrial Fibrillation on Mortality After Coronary Artery Bypass Grafting

Bramer, Sander; Straten, Albert H.M. van; Hamad, Mohamed A. Soliman; Berreklouw, Eric; Martens, Elisabeth J.; Maessen, Jos G.

doi:10.1016/j.athoracsur.2010.03.083

Cited by 93 publications

(53 citation statements)

References 24 publications

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“…Even when using this comprehensive adjustment, POAF remained a significant and independent predictor of longterm mortality. The results of our study, supported by the results of other well-conducted studies in the field of coronary surgery, 1,5,8,11 provide strong evidence for a significant impact of POAF on long-term survival.…”

Section: Impact Of Poaf On Operative Mortalitysupporting

confidence: 87%

“…1,3,4,6,8,11 Kalavrouziotis et al found that unadjusted mortality rates were similar in patients with and without POAF (3% vs 2.5% respectively, P = 0.99) in a series of 7347 patients undergoing valvular and/or coronary surgery. 6 In contrast, Villareal et al studied patients with isolated CABG and found a strong and independent association between POAF and operative mortality.…”

Section: Impact Of Poaf On Operative Mortalitymentioning

confidence: 98%

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Statins Reduce Short‐ and Long‐Term Mortality Associated With Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting: Impact of Postoperative Atrial Fibrillation and Statin Therapy on Survival

Girerd¹,

Daleau²,

Voisine

et al. 2012

Clinical Cardiology

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Background:Postoperative atrial fibrillation (POAF) is a frequent complication of coronary artery bypass grafting (CABG) surgery. The objective of this study was to determine the impact of POAF on both short‐ and long‐term mortality following isolated CABG.Hypothesis:POAF is associated with a poorer short and long‐term mortality following CABG.Methods:We retrospectively analyzed the preoperative and operative data of 6728 consecutive patients undergoing a first isolated CABG.Results:The incidence of POAF was 27.8%. Operative mortality was higher in patients with POAF compared to those without POAF (2.3% vs 0.9%, P < 0.001). On multivariate analysis, POAF remained an independent predictor of operative mortality (odds ratio [OR]: 1.78, P = 0.01). Patients with POAF also had reduced long‐term survival (6‐year survival: 85.3% vs 89.2%, P < 0.001). After adjusting for other predictors of mortality, POAF was significantly associated with increased long‐term mortality (hazard ratio [HR]: 1.35, P = 0.04). Of note, after adjustment for potential confounders, statin treatment had a highly protective effect in POAF patients for both operative mortality (OR: 0.38, P = 0.003) and long‐term mortality (HR: 0.62, P = 0.03), whereas it had no significant effect in patients without POAF.Conclusions:POAF is an independent predictor of both short‐ and long‐term mortality following CABG. Moreover, statin therapy was independently associated with better survival in patients with POAF.Dr. Pibarot holds the Canada Research Chair in Valvular Heart Diseases, Canadian Institutes of Health Research. Dr. Mathieu is a research scholar from the Fonds de Recherches en Santé du Québec, Montreal, Canada. Dr. Després has served as a speaker for Abbott Laboratories, AstraZeneca, Solvay Pharma, GlaxoSmithKline, and Pfizer Canada Inc.; has received research funding from Eli Lilly Canada; and has served on the advisory boards of Novartis, Theratechnologies, Torrent Pharmaceuticals Ltd., and Sanofi‐Aventis. The authors have no other funding, financial relationships, or conflicts of interest to disclose.

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Section: Impact Of Poaf On Operative Mortalitysupporting

confidence: 87%

Section: Impact Of Poaf On Operative Mortalitymentioning

confidence: 98%

Statins Reduce Short‐ and Long‐Term Mortality Associated With Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting: Impact of Postoperative Atrial Fibrillation and Statin Therapy on Survival

Girerd¹,

Daleau²,

Voisine

et al. 2012

Clinical Cardiology

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“…[2][3][4] However, more recent studies show atrial fibrillation, following CABG surgery, to be associated with both increased immediate complications and costs, 5 as well as poorer long term outcomes. [6][7][8] El-chami and colleagues' 1 study provides further evidence regarding the detrimental effect of new-onset post-CABG AF on long-term survival, and more importantly, provides new data regarding the effectiveness of warfarin at discharge.…”

Section: Introductionmentioning

confidence: 99%

Commentary on : New-Onset Atrial Fibrillation Predicts Long-Term Mortality After Coronary Artery Bypass Graft by El-chami et.al

Filardo¹

2010

J.A.F.I.B

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“…Implantable devices can be utilised for longer periods of continuous cardiac monitoring. Ziegler et al described supraventricular ectopy, detected from implantable pacemakers and defibrillators, occurring in 28% of subjects with previous thrombo-embolic cerebrovascular events [8]. Implantable loop recorders are being utilised in a current trial, the CRYSTAL AF trial, to prospectively evaluate the long term detection of AF following cryptogenic stroke [9].…”

Section: Journal Of Atrial Fibrillation Journal Reviewmentioning

confidence: 99%

Supraventricular Ectopic Activity: When Excessive it is not all Benign!

Thomas¹,

Nguyen²

2010

J.A.F.I.B

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Stroke is a significant cause of mortality and disabling morbidity. The major subtypes of stroke are divided into thrombo-embolic, haemorrhagic and cryptogenic, with each having different predisposing risk factors and management strategies. Atrial fibrillation (AF) is the commonest arrhythmia predisposing to thrombo-embolic stroke. The incidence of AF increases with age, affecting up to 5% in the elderly population. Electrophysiology studies have implicated that spontaneous atrial ectopic beats that originate in or near pulmonary veins adjacent to the left atrium, may initiate paroxysms of AF

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The Impact of New-Onset Postoperative Atrial Fibrillation on Mortality After Coronary Artery Bypass Grafting

Cited by 93 publications

References 24 publications

Statins Reduce Short‐ and Long‐Term Mortality Associated With Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting: Impact of Postoperative Atrial Fibrillation and Statin Therapy on Survival

Statins Reduce Short‐ and Long‐Term Mortality Associated With Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting: Impact of Postoperative Atrial Fibrillation and Statin Therapy on Survival

Commentary on : New-Onset Atrial Fibrillation Predicts Long-Term Mortality After Coronary Artery Bypass Graft by El-chami et.al

Supraventricular Ectopic Activity: When Excessive it is not all Benign!

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