The impact of non-deproteinization on physicochemical and biological properties of natural rubber latex for biomedical applications

Asami, Jessica; Quevedo, Bruna V.; Santos, Arnaldo R.; Giorno, Luciana Pastena; Komatsu, Daniel; de Rezende Duek, Eliana Aparecida

doi:10.1016/j.ijbiomac.2023.126782

Cited by 7 publications

References 57 publications

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Effect of Egg White Protein and Water Content on the Stabilization Mechanisms of Natural Rubber Latex Foams Obtained from Microwave Radiation

Amezúa‐Arranz,

Salmazo,

López‐Gil

et al. 2024

Adv Eng Mater

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The global plastic consumption, as one of the paramount concerns of our society, open new paths of investigation in green materials. This study presents our contribution to the field with the obtention of natural rubber latex foams using egg white powder as bio stabilizing agent. The route followed to develop these samples is based on a two‐step process, a previous aeration, followed by microwave dehydration. This synthesis route is greener and eco‐friendlier than conventional ones due to the use of biobased bulk materials, the utilisation of microwave radiation which reduces the energy consumption in comparison with conventional heating methods and the elimination of the vulcanization process typically used when producing latex foams. In this work a deep study of the effect of egg white protein on natural rubber latex foams obtained at three water content levels (i.e. 40, 70, 90 phr) is carried out. The density and cellular structure parameters are measured for the formulations of liquid and solid foams which led to stable final samples in order to comprehend the stabilization mechanisms due to the presence of the egg white and the effect of water content in these systems. With the route developed in this research it has been possible to produce open cell natural rubber latex foams with densities as low as 53 kg/m3 and cell sizes as low as 114 µm.This article is protected by copyright. All rights reserved.

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Effect of Egg White Protein and Water Content on the Stabilization Mechanisms of Natural Rubber Latex Foams Obtained from Microwave Radiation

Amezúa‐Arranz,

Salmazo,

López‐Gil

et al. 2024

Adv Eng Mater

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Development of co‐electrospun membrane composed poly(l‐co‐d,l‐lactic acid) and natural rubber with potential application in dermal dressing

Pinto,

V. Quevedo,

Komatsu

et al. 2024

J of Applied Polymer Sci

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Wound healing represents a global challenge for the healthcare system, resulting in substantial costs and physical and emotional impacts on individuals. There is an increasing demand for innovative alternatives to treat this condition. The co‐electrospinning technique enables the production of porous membrane composed of natural and synthetic polymers, which exhibit unique functions and adjustable mechanical properties that assist in the tissue healing process. Therefore, the present study aims to investigate the physical–chemical, mechanical, and biological properties of membrane composed of poly(l‐co‐d,l‐lactic acid) (PLDLA) co‐electrospun with different concentrations of natural rubber (NR) (1.5%, 2.0%, and 2.5%). Scanning electron microscopy analysis revealed the porous surface of the membranes. Fourier‐transform infrared spectroscopy confirmed the presence of NR in the material. The low Young's modulus obtained in the mechanical tensile test for the PLDLA membrane co‐electrospun with 1.5% NR indicated its elastic capacity under low tension. The results corroborate with the differential scanning calorimetry, and thermogravimetric analysis, which highlights the compatibility between polymers at this specific proportion, as well as in vitro biocompatibility. The findings underscore the potential of PLDLA and NR co‐electrospun membranes as promising candidates for formulating biomaterials for applications such as dermal dressings.

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Second‐degree burns treatment: Preclinical in vivo approaches using natural latex rubber containing Aloe vera extract

de Carvalho,

Quevedo,

Goldenberg

et al. 2024

J of Applied Polymer Sci

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Natural rubber latex (NRL) obtained from Hevea brasiliensis is emerging as a viable and economical alternative for biomedical treatments, particularly for dermal injuries. Its effectiveness is enhanced when combined with bioactive molecules, such as those found in Aloe vera (AV), known for their healing properties and are commonly used in low‐cost wound healing therapies. Thus, this study evaluated the physicochemical and biological properties of NRL incorporated with 25%, 35%, and 50% AV, both in vitro and in vivo. FTIR analyses revealed only physical interactions between NRL and AV, facilitating their release, as evidenced by the release profile. In vitro assays indicated improved biocompatibility in samples composed of 25% and 35% AV, while complete cell death occurred at 50% AV. Histological evaluations of second‐degree burn models in rats showed greater re‐epithelialization of the epidermis with 35% AV after 14 days of treatment. However, 50% AV highlighted the importance of avoiding overdosing to prevent tissue necrosis. Despite the differences observed between in vitro and in vivo results, NRL membranes containing AV are a promising approach for future clinical trials in skin wounds treatment, offering an effective and affordable solutions for skin regeneration in clinical settings.

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The impact of non-deproteinization on physicochemical and biological properties of natural rubber latex for biomedical applications

Cited by 7 publications

References 57 publications

Effect of Egg White Protein and Water Content on the Stabilization Mechanisms of Natural Rubber Latex Foams Obtained from Microwave Radiation

Effect of Egg White Protein and Water Content on the Stabilization Mechanisms of Natural Rubber Latex Foams Obtained from Microwave Radiation

Development of co‐electrospun membrane composed poly(l‐co‐d,l‐lactic acid) and natural rubber with potential application in dermal dressing

Second‐degree burns treatment: Preclinical in vivo approaches using natural latex rubber containing Aloe vera extract

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