The impact of non‐motor symptoms on the quality of life of Parkinson's disease patients: a longitudinal study

Prakash, Kumar M.; Nadkarni, Nivedita; Lye, Weng Kit; Yong, Ming-Hui; Tan, Eng‐King

doi:10.1111/ene.12950

Cited by 195 publications

(136 citation statements)

References 32 publications

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“…A study from Singapore [56] reported that sleep, mood, and attention disorders have a significant negative impact on QoL, which is similar to data from Europe [57]. Given that these were the NMS we identified to be most prevalent in Asian patients, it emphasises its importance, the need to address them in clinical practice, and the possible future requirement of ethnicity-based personalised medicine [56]. …”

Section: Discussionsupporting

confidence: 55%

“…Li et al [55] demonstrated, in a cross-sectional study in China, that the domains of sleep/fatigue, mood, gastrointestinal, urinary, and miscellaneous had a particularly meaningful negative impact on the patient's QoL. A study from Singapore [56] reported that sleep, mood, and attention disorders have a significant negative impact on QoL, which is similar to data from Europe [57]. Given that these were the NMS we identified to be most prevalent in Asian patients, it emphasises its importance, the need to address them in clinical practice, and the possible future requirement of ethnicity-based personalised medicine [56].…”

Section: Discussionmentioning

confidence: 99%

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Non-Motor Symptoms Assessed by Non-Motor Symptoms Questionnaire and Non-Motor Symptoms Scale in Parkinson's Disease in Selected Asian Populations

Sauerbier

Jitkritsadakul²,

Titova³

et al. 2017

Neuroepidemiology

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Background: Ethnic variations have been described in medical conditions, such as hypertension, diabetes, and multiple sclerosis. Whether ethnicity plays a role in Parkinson's disease (PD), particularly with regard to non-motor symptoms (NMS), remains unclear. Existing literature is diverse, controversial, and inadequately documented. This review aims to analyse and report the currently available literature on NMS, specifically in Asian PD patients. Summary: We conducted a literature review using PubMed, searching for articles and currently available publications that reference and assess NMS in PD patients living in Asia using the validated NMS Questionnaire (NMS Quest) and NMS Scale (NMSS). In total, 24 articles were included: 12 using the NMS Quest and 12 using the NMSS. Symptoms of constipation, memory impairment, and nocturia were the most frequently self-reported symptoms (NMS Quest) in selected Asian populations, while symptoms within the domains sleep/fatigue, attention/memory, and mood/apathy were most prevalent when applying the health-professional completed NMSS. Key Messages: NMS are generally prevalent and highly burdensome within selected Asian PD populations living in countries included in this review. Our review suggests that NMS-driven phenotypic heterogeneity is present in Asian patients, and compared to Western PD populations there might be variations in assessed NMS.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Non-Motor Symptoms Assessed by Non-Motor Symptoms Questionnaire and Non-Motor Symptoms Scale in Parkinson's Disease in Selected Asian Populations

Sauerbier

Jitkritsadakul²,

Titova³

et al. 2017

Neuroepidemiology

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“…Taken together, these NMS are associated with severe disability, shortened life expectancy, reduced quality of life of patients and caregivers, and increased health-care costs [15].…”

Section: Cognitive Impairment In Pdmentioning

confidence: 99%

Levodopa/Carbidopa Intestinal Gel for Treatment of Advanced Parkinson’s Disease: An Update on the Effects of Cognitive Functions

Latino¹,

Tagliente²,

Pellicano³

et al. 2017

APD

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Cognitive impairment is a frequent non-motorsymptom of Parkinson's disease (PD). In early disease stage, this takes the features of dysexecutive syndrome, and is mostly dependent on derangement of frontostriatal circuitries. In advanced stages, worsening of dysexecutive symptoms is accompanied by disorientation and memory deficit leading to dementia in 30% of cases, due to multiple neurotransmitter derangement. Dysexecutive symptoms in the early stages of PD may benefit from dopamine replacement therapy (DRT). Conversely, severe cognitive symptoms in more advanced stages are frequently aggravated by DRT. In particular, pulsatile stimulation of dopaminergic receptors by orally administered levodopa (LD) plays a significant negative role on cognitive and neuropsychiatric symptoms in advanced PD. The introduction of a gel of LD-carbidopa for continuous intestinal administration (LCIG) allows marked stabilization of plasma LD concentrations and provides benefit on motor fluctuations and dyskinesia of significantly greater magnitude than conventional oral administration in advanced PD patients. The results from several preliminary studies suggest that efficacy of LCGI on motor symptoms may be accompanied by good tolerability and potential benefit on several non-motor symptoms, including cognitive impairment. Future studies with longer observation period and larger cohorts are advised to confirm these preliminary observations.

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“…Autonomic dysfunction symptoms significantly impair the quality of life of PD patients, even more than motor symptoms. 6 Autonomic dysfunctions are part of a spectrum of non-motor symptoms in patients with PD. 7 Nonmotor symptoms may precede typical motor features of PD by several years.…”

Section: Introductionmentioning

confidence: 99%

Male Sexual Disorders in Patients with Parkinson Disease: Treatment with Natural Remedies

Mireille¹

2017

ATROA

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In patients with PD, sexual disorders usually begin after the onset AbstractParkinson's disease (PD) is a neurodegenerative disorder caused by a progressive deterioration of midbrain dopamine neurons in the substantia nigra. The incidence of PD in male is higher than that in women, but psychological symptoms are as varied as the motor symptoms in both gender. Psychological symptoms encompass a decrease in sexual desire with a long list of thymic, cognitive, behavioral, and neuropsychiatric complications. Their origin can be attributed to the natural course of the disease, side effects of treatment, or both. Clinical researches are mainly focused on the dominant motor symptoms of PD, but the nonmotor features of PD also need attention. Sexual dysfunctions (SD) are one of the most neglected nonmotor symptoms in PD. SD usually begin after the onset of motor disorders and many patients receiving DA agonists as treatment manifest uncontrollable sexual desire, playing thus a major role in the deterioration of the life's quality of patients and their partners. Research articles were retrieved from PubMed and Google using relevant keywords. Overall, this review emphasize on the sexual disorders widely reported in patients with PD and the types of natural products that are potential future supplementary agents in their control.

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The impact of non‐motor symptoms on the quality of life of Parkinson's disease patients: a longitudinal study

Abstract: Unlike motor disabilities, NMSs burden, in particular sleep, mood and attention, have a significant impact on the QoL of PD patients over a 2-year follow-up period.

Cited by 195 publications

References 32 publications

Non-Motor Symptoms Assessed by Non-Motor Symptoms Questionnaire and Non-Motor Symptoms Scale in Parkinson's Disease in Selected Asian Populations

Non-Motor Symptoms Assessed by Non-Motor Symptoms Questionnaire and Non-Motor Symptoms Scale in Parkinson's Disease in Selected Asian Populations

Levodopa/Carbidopa Intestinal Gel for Treatment of Advanced Parkinson’s Disease: An Update on the Effects of Cognitive Functions

Male Sexual Disorders in Patients with Parkinson Disease: Treatment with Natural Remedies

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