The impact of obesity on heart failure

Zhai, Alexander; Haddad, Haissam

doi:10.1097/hco.0000000000000370

Cited by 36 publications

(38 citation statements)

References 96 publications

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“…9 It is currently known that, in severe obesity, cardiac output is increased at the expense of increased circulating volume, leading to a state of chronically elevated preload, which favors the increase of ventricular dimensions, of parietal stress and LV mass. 8,12,14,25,26 This set of chronic hemodynamic changes can lead to cardiac structural impairment with cardiac performance loss.…”

Section: Hemodynamic and Morphological Changes Associated With Obesitymentioning

confidence: 99%

“…20 In addition to correlating with obesity, that change correlates with obesity duration. 8 The Framingham Heart Study has shown that BMI is an independent predictor of LV mass, mainly when BMI exceeds 30 kg/m 2 . 14 The literature is highly controversial regarding the LVH pattern related to obesity.…”

Section: Hemodynamic and Morphological Changes Associated With Obesitymentioning

confidence: 99%

“…2 In Brazil, according to the BREATHE study, 3 coronary artery disease is the major cause of HF (30.3%), whose major causes of decompensation are poor medication adherence (30.0%), infections (23.0%) and inadequate control of water and sodium ingestion (9.0%). 3 Heart failure is currently known to be associated with obesity, 2,[4][5][6][7][8][9][10][11][12][13][14][15] regardless of the presence of comorbidities, such as arterial hypertension (AH) and coronary artery disease. 16,17 The Framingham Heart Study reports that to every 1-kg/m 2 increase in body mass index (BMI), the risk of developing HF increases by 5.0% in men and by 7.0% in women.…”

Section: Introductionmentioning

confidence: 99%

“…16,17 The Framingham Heart Study reports that to every 1-kg/m 2 increase in body mass index (BMI), the risk of developing HF increases by 5.0% in men and by 7.0% in women. 8 In addition to BMI, waist circumference and waist-hip ratio have been shown to be associated with HF in several cross-sectional and prospective studies. 12 Obese individuals have a two-fold increased risk of premature death as compared to non-obese individuals, in addition to a five-fold increased risk of death from cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Obesity and Bariatric Surgery in the Outcome of Patients with Heart Failure

Mourilhe-Rocha

Salvino

2019

International Journal of Cardiovascular Sciences

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Currently, the association between obesity and heart failure (HF) is increasingly known. Patients with advanced obesity who suffer from HF without an identifiable cause can be diagnosed as having obesity-associated cardiomyopathy. Although data suggest that obesity may reduce mortality in HF, weight loss, especially in the presence of morbid obesity, reduces symptoms and improves the quality of life of those patients.Bariatric surgery is the major treatment available for sustained weight loss in morbid obesity. Observational studies have demonstrated an improvement in ventricular structure and function of morbidly obese patients with HF who underwent that procedure. Thus, despite the risks, bariatric surgery should be considered for patients with HF, because of its potential for reducing associated comorbidities and improving quality of life and functional capacity, in addition to making eligible for heart transplantation those excluded due to high body mass index.

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Section: Hemodynamic and Morphological Changes Associated With Obesitymentioning

confidence: 99%

Section: Hemodynamic and Morphological Changes Associated With Obesitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of Obesity and Bariatric Surgery in the Outcome of Patients with Heart Failure

Mourilhe-Rocha

Salvino

2019

International Journal of Cardiovascular Sciences

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“…The relation between obesity and heart failure (HF) is complex. Although obese people have twice the risk to develop HF, obesity is protective in patients with established HF, a phenomenon termed “the obesity paradox.” 1–4 Despite this, many of these patients proceed to stage D HF. Morbid obesity (defined as a body mass index (BMI) ⩾ 35 kg/m 2 ) is a limitation to candidacy for heart transplantation (HTx) and those who are obese (defined as a BMI ⩾ 30 kg/m 2 ) and undergo HTx have worse outcomes.…”

Section: Introductionmentioning

confidence: 99%

Weight evolution after implantation of left ventricular assist device: Do we need to interfere?

et al. 2020

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Objectives: Weight change after left ventricular assist device implantation may influence outcomes and can affect transplant candidacy. We questioned if there is a systematic weight change after left ventricular assist device implantation and examined the evolution in functional capacity. Methods: A retrospective analysis of 84 patients who received a left ventricular assist device in Universitaire Ziekenhuizen Leuven between 2008 and 2016 was performed. Patients were divided into four groups based on their baseline body mass index, and we also examined weight evolution for patients presenting with new-onset heart failure versus those suffering from chronic heart failure. Body mass index was assessed at baseline, 6, 12, 18, and 24 months. To indicate the functional capacity, we analyzed the results of routine 6-Minute Walk Test performed at 6, 12, and 18 months. Results: During the first 6 months after surgery, the underweight patients evolved to normal weight and the body mass index of the obese patients reduced significantly. Afterward, all patients gained weight. The weight loss of the obese was not maintained over time. The weight of patients with normal weight and overweight evolved to overweight and obesity, respectively. No body mass index changes were demonstrated for patients presenting with new-onset heart failure, and the body mass index of patients suffering from chronic HF significantly increased. There was a significant improvement in functional capacity at 6 months, but this level remained unchanged at 12 and 18 months after surgery. Conclusion: Although the initial 6 months evolve beneficial, all patients gain weight in the second year and do not further improve their exercise capacity.

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Adverse Pregnancy Outcomes and Incident Heart Failure in the Women’s Health Initiative

et al. 2021

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Key Points Question Are adverse pregnancy outcomes independently associated with the development of heart failure among postmenopausal women? Findings In this cohort study including 10 292 Women’s Health Initiative participants, hypertensive disorders of pregnancy were independently associated with incident heart failure, particularly heart failure with preserved ejection fraction, in postmenopausal women. Meaning These findings suggest that hypertensive disorders of pregnancy are sex-specific factors associated with risk of heart failure, particularly heart failure with preserved ejection fraction.

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The impact of obesity on heart failure

Cited by 36 publications

References 96 publications

Impact of Obesity and Bariatric Surgery in the Outcome of Patients with Heart Failure

Impact of Obesity and Bariatric Surgery in the Outcome of Patients with Heart Failure

Weight evolution after implantation of left ventricular assist device: Do we need to interfere?

Adverse Pregnancy Outcomes and Incident Heart Failure in the Women’s Health Initiative

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