The Impact of Obesity on Disease Activity and Treatment Response in Rheumatoid Arthritis

Poudel, Dilli Ram; George, Michael; Baker, Joshua F.

doi:10.1007/s11926-020-00933-4

Cited by 34 publications

(19 citation statements)

References 45 publications

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“…These results indicate that a low BMI may be an independent risk factor for radiographic progression in RA. In fact, recent studies demonstrated that obesity in patients with RA was associated with a lower rate of radiographic progression (25)(26)(27)(28). However, because this population of patients with obesity showed low treatment response (27,28), further research is needed to determine whether low body weight is a direct cause of bone destruction or a confounding factor.…”

Section: Discussionmentioning

confidence: 99%

Association of Polygenic Risk Scores With Radiographic Progression in Patients With Rheumatoid Arthritis

Honda

Ikari

Yano

et al. 2022

Arthritis & Rheumatology

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Objective To investigate whether polygenic risk scores obtained using data from a genome‐wide association study (GWAS) of rheumatoid arthritis (RA) susceptibility can be predictors of radiographic progression. Methods We constructed polygenic risk scores using GWAS summary data on associations of single‐nucleotide polymorphisms with RA susceptibility. The polygenic risk scores were stratified into quintiles based on levels of significance (ranging from top quintile of polygenic risk scores to bottom quintile). In addition, change in the Sharp/van der Heijde score (SHS) of radiographic progression over the first 5 years after onset of RA was assessed. The change in SHS over 5 years was stratified according to quartiles, with the top quartile of change in SHS defined as severe radiographic progression (score change of >35 points) and the remaining 3 quartiles defined as nonsevere radiographic progression. Polygenic risk scores were assessed for their ability to predict the SHS status over 5 years in a training set (n = 500 RA patients) for selection of the best model, and in a testing set (n = 740 RA patients) for validation of the data. We evaluated the performance of the polygenic risk score as a predictor of severe radiographic progression in univariable and multivariable analyses with inclusion of other factors. Results Polygenic risk scores constructed from 43,784 single‐nucleotide polymorphisms significantly differed between patients who experienced severe radiographic progression and those with nonsevere radiographic progression in both the training set (P = 0.0064) and the testing set (P = 0.017). Patients with polygenic risk scores in the top quintile had a higher risk of severe progression compared to those with polygenic risk scores in the bottom quintile (odds ratio [OR] 1.90, P = 0.0022), and the risk of severe radiographic progression was even higher when restricted to patients who were younger at disease onset (OR 5.06, P = 0.00038). The group with polygenic risk scores in the top quintile and the anti–citrullinated protein antibody (ACPA)–positive group had significantly higher proportions of patients with severe radiographic progression (P = 0.00052 and P = 0.0022, respectively) compared to the remaining groups. Multivariable analysis showed that polygenic risk score (P = 0.00019) as well as female sex (P = 0.0033), ACPA positivity (P = 0.0023), and body mass index (P = 0.024) were independent risk factors for severe radiographic progression. Conclusion A polygenic risk score that is derived from GWAS data on RA susceptibility is associated with the level of severity of radiographic progression in patients with RA.

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Section: Discussionmentioning

confidence: 99%

Association of Polygenic Risk Scores With Radiographic Progression in Patients With Rheumatoid Arthritis

Honda

Ikari

Yano

et al. 2022

Arthritis & Rheumatology

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“…In addition, the fact that overweight or obese RA patients do less physical activity than patients of normal weight has also been reported in a study by Hugo et al [54]. As disease activity has been shown to be higher and disabilities more severe in obese RA patients, increasing physical activity in these patients might be of particular importance [55], especially when considering that physical activity can reduce the inflammatory process, metabolic syndromes, and other comorbidities (osteoarthritis, depression, diabetes) [54,55].…”

Section: Discussionmentioning

confidence: 67%

Factors Associated with Objectively Measured Physical Activity in Patients with Seropositive Rheumatoid Arthritis

Haider

Sedlak

Kapan

et al. 2020

IJERPH

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Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease, which is associated with low levels of physical activity (PA). However, the factors related to low physical activity levels have rarely been studied. Methods: In this cross-sectional study, 70 seropositive RA patients were included. Physical activity was objectively assessed with an ActiGraph GT3X+ accelerometer. In addition, body mass index, smoking status, work ability, and clinical parameters (functional disabilities, disease activity, disease duration, pain, and inflammation parameters) were measured. Results: RA patients performed a mean of 215.2 (SD: 136.6) min a week of moderate physical activity and 9.1 (SD: 26.3) min of vigorous physical activity. The total amount of moderate and vigorous physical activity (MVPA) was associated with BMI, and functional disabilities. In addition, non-smokers and patients with better work ability did more MVPA. No association could be seen with disease activity, disease duration, pain, and inflammatory markers. After mutual adjusting of all the variables, only BMI showed a significant relationship with MVPA. Conclusions: RA patients perform de facto no physical activity with vigorous intensity. Factors related to low physical activity are BMI, functional disabilities, workability and smoking status, whereas due to the study design no causal and temporal link could be made.

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“…Also, it is clear that obesity is associated with more severe symptoms among RA patients. [ 48 ] Resveratrol has been highlighted too by its anti‐obesity properties. [ 49 ] Future studies should evaluate if resveratrol could be an effective co‐adjuvant medication in the management of RA patients, also in RA patients with obesity.…”

Section: Discussionmentioning

confidence: 99%

Autophagy Activation by Resveratrol Reduces Severity of Experimental Rheumatoid Arthritis

Fernández-Rodríguez

Almonte-Becerril

Ramil-Gómez

et al. 2020

Molecular Nutrition Food Res

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Scope Previous work reported that dietary supplementation with resveratrol lowers synovial hyperplasia, inflammatory and oxidative damage in an antigen‐induced arthritis (AIA) model. Here, it is investigated whether resveratrol can regulate the abnormal synovial proliferation by inducing autophagy and controlling the associated inflammatory response. Methods and results Animals treated with resveratrol 8 weeks before AIA induction show the highest significant signal for microtubule‐associated protein 1 light chain 3 by confocal microscopy. Besides, resveratrol significantly reduces p62 expression, but it does not increase the signal of beclin‐1. Also, active caspase‐3 expression, as well as poly(ADP‐ribose) polymerase, is upregulated in the AIA group, and is significantly reduced in resveratrol‐treated AIA group. Resveratrol also mitigates angiopoietin‐1 and vascular endothelial growth factor signals. Finally, resveratrol significantly reduces the serum levels of IL‐1β, C reactive protein, and prostaglandin E2, as well as nuclear factor κB synovial tissue expression, which shows a significant correlation with p62 expression. Conclusion Dietary supplementation with resveratrol induces the noncanonical autophagy pathway and limits the cross‐talk with inflammation, which in consequence modulates the synovial hyperplasia. Preventive strategies that incorporate dietary intervention with resveratrol may offer a potential therapeutic alternative to drugs to influence the risk of rheumatoid arthritis and influence its course.

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The Impact of Obesity on Disease Activity and Treatment Response in Rheumatoid Arthritis

Cited by 34 publications

References 45 publications

Association of Polygenic Risk Scores With Radiographic Progression in Patients With Rheumatoid Arthritis

Association of Polygenic Risk Scores With Radiographic Progression in Patients With Rheumatoid Arthritis

Factors Associated with Objectively Measured Physical Activity in Patients with Seropositive Rheumatoid Arthritis

Autophagy Activation by Resveratrol Reduces Severity of Experimental Rheumatoid Arthritis

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