The impact of organized mammography service screening on breast carcinoma mortality in seven Swedish counties

Abstract

BACKGROUND The evaluation of organized mammographic service screening programs is a major challenge in public health. In particular, there is a need to evaluate the effect of the screening program on the mortality of breast carcinoma, uncontaminated in the screening epoch by mortality from 1) cases diagnosed in the prescreening period and 2) cases diagnosed among unscreened women (i.e., nonattenders) after the initiation of organized screening. METHODS In the current study, the authors ascertained breast carcinoma deaths in the prescreening and screening epochs in 7 Swedish counties from tumors diagnosed in these epochs and in the age group 40–69 years in 6 counties and 50–69 years in 1 county. Data regarding deaths were obtained from the Uppsala Regional Oncologic Center in conjunction with the National Cause of Death Register. The total number of women in the eligible age range living in each county was obtained from the annual population data of Statistics Sweden. Detailed screening data were provided by the screening centers in the seven counties, including the number of invited, the number attended, and whether each individual breast carcinoma case was exposed (screen‐detected and interval cases combined) or unexposed (not‐invited or nonattenders) to mammographic screening. There were 2044 breast carcinoma deaths from 14,092 incident tumors diagnosed in the prescreening and screening epochs, and the total number of person‐years was 7.5 million. Data were analyzed using Poisson regression with corrections for self‐selection bias and lead‐time bias when appropriate. RESULTS The mortality reduction for breast carcinoma in all 7 counties combined for women actually exposed to screening compared with the prescreening period was 44% (relative risk [RR] = 0.56; 95% confidence interval [95% CI], 0.50–0.62). When all incident tumors were considered, both those exposed and those unexposed to screening combined, counties with > 10 years of screening were found to demonstrate a significant 32% mortality reduction (RR = 0.68; 95% CI, 0.60–0.77) and counties with ≤ 10 years of screening showed a significant 18% reduction in breast carcinoma mortality (RR = 0.82; 95% CI, 0.72–0.94) for the screening epoch compared with the prescreening epoch. Within the screening epoch, after adjustment for self‐selection bias, a 39% mortality reduction (RR = 0.61; 95%CI, 0.55–0.68) was observed in association with invitation to screening. CONCLUSIONS Organized service screening in 7 Swedish counties, covering approximately 33% of the population of Sweden, resulted in a 40–45% reduction in breast carcinoma mortality among women actually screened. The policy of offering screening is associated with a mortality reduction in breast carcinoma of 30% in the invited population, exposed and unexposed combined. The results of the current study indicate that the majority of the breast carcinoma mortality reduction is indeed due to the screening. [See editorial on pages 451–7, this issue.] Cancer 2002;95:458–69. © 2002 American Cancer Socie...

Breast cancer mortality trends in two areas of the province of Florence, Italy, where screening programmes started in the 1970s and 1990s

“…Decreases in breast cancer mortality have been variously reported following the introduction of mammographic screening on a regional level (Tornberg et al, 1994;Quinn and Allen, 1995;Garne et al, 1997;Barchielli and Paci, 2001;Broeders et al, 2001;Tabar et al, 2001;Duffy et al, 2002). Randomised prospective trials indicate that benefits in terms of cumulative breast cancer mortality start to emerge 4 -10 years after randomisation (Nyström et al, 2002).…”

Experiences and perceptions about undergoing mammographic screening: a qualitative study involving women from a county in Sweden

“…Mammographic screening, which is an x-ray examination, is one option for an early detection of potential breast malignancies and consequently, for the commencement of treatment (Vainio & Bianchini, 2002; Wilson & Jungner, 1968). The pros and cons of screening for breast cancer have been debated; negative effects, such as the risk of unnecessary treatment due to over-diagnosis (Jørgensen, Keen, & Gøtzsche, 2011; Løberg, Lousdal, Bretthauer, & Kalager, 2015), have been mentioned, while a mortality reduction has been a counter argument (Duffy et al, 2002; Independent UK Panel on Breast Cancer Screening, 2012). However, the organized population-based mammographic screening programme is perceived as effective, and the majority of the countries in the European Union (except three) implemented it in 2016 (Ponti et al, 2017).…”

Increased incidence of invasive breast cancer after the introduction of service screening with mammography in Sweden

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