The impact of oxandrolone on length of stay following major burn injury: A clinical practice evaluation

Cochran, Amalia; Thuet, Wiley; Holt, Brennen; Faraklas, Iris; Smout, Randall J.; Horn, Susan D.

doi:10.1016/j.burns.2013.04.002

Cited by 18 publications

(7 citation statements)

References 14 publications

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“…According to Pham and colleagues, treatment with oxandrolone might be associated with improved survival. (66)(67)(68)(69)(70)(71) The most concerning adverse effect of oxandrolone is hepatotoxicity. However, McCullough and colleagues compared liver dysfunction, measured by liver transaminases, among thermally injured adults and showed no significant differences in liver dysfunction between treatment and control groups.…”

Section: Testosterone and Oxandrolonementioning

confidence: 99%

Anabolic and anticatabolic agents used in burn care: What is known and what is yet to be learned

Gus

Shahrokhi

Jeschke

2020

Burns

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Major thermal injury induces profound metabolic derangements secondary to an inflammatory "stress-induced" hormonal environment. Several pharmacological interventions have been tested in an effort to halt this postburn hypermetabolic syndrome. Insulin, insulin growth factor 1, insulin growth factor binding protein 3, metformin, human growth hormone, thyroid hormones, testosterone, oxandrolone, and propranolol, among others, have been proposed to have anabolic or anticatabolic effects. The aim of this broad analysis of pharmacological interventions was to raise awareness of treatment options and to help establishing directions for future clinical research efforts. A PubMed search was conducted on the anabolic and anticatabolic agents used in burn care. One hundred and thirty-five human studies published between 1999 and 2017 were included in this review. The pharmacological properties, rationale for the treatments, efficacy considerations and side effect profiles are summarized in the article. Many of the drugs tested for investigational purposes in the severely thermally injured are not yet gold-standard therapies in spite of their potential benefit. Propranolol and oxandrolone have shown great promise but further evidence is still needed to clarify their potential use for anabolic and anticatabolic purposes.

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Section: Testosterone and Oxandrolonementioning

confidence: 99%

Anabolic and anticatabolic agents used in burn care: What is known and what is yet to be learned

Gus

Shahrokhi

Jeschke

2020

Burns

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“…Oxandralone improves muscle protein catabolism via a decrease in efflux of amino acids and influx into the cell 102 , 103 . In addition, oxandrolone has been used clinically in burn patients to reduce weight loss and improve lean body mass during the acute phase of injury 3 , 102 , 104 – 106 . In a double‐blinded randomized study, it was shown that the administration of 10 mg bid of oxandrolone decreased hospital stay and improved mortality 107 .…”

Section: Pharmacologic Modalities In Alleviating the Postburn Patholomentioning

confidence: 99%

“…Anabolic steroid analogues such as oxandrolone were developed to maximize the clinical advantage of testosterone while decreasing the androgenic side effects of this naturally occurring hormone. Oxandralone improves muscle protein catabolism via a decrease in efflux of amino acids and influx into the cell 102 , 103 . In addition, oxandrolone has been used clinically in burn patients to reduce weight loss and improve lean body mass during the acute phase of injury 3 , 102 , 104 – 106 .…”

Section: Pharmacologic Modalities In Alleviating the Postburn Patholomentioning

confidence: 99%

“…102,103 In addition, oxandrolone has been used clinically in burn patients to reduce weight loss and improve lean body mass during the acute phase of injury. 3,102,[104][105][106] In a double-blinded randomized study, it was shown that the administration of 10 mg bid of oxandrolone decreased hospital stay and improved mortality. 107 Another randomized double-blinded study also found similar findings, in that administration of 0.1 mg/kg bid decreased length of hospital stay, preserved lean body mass, and promoted hepatic protein synthesis.…”

Section: Oxandrolonementioning

confidence: 99%

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Nutrition and Anabolic Pharmacotherapies in the Care of Burn Patients

Abdullahi

Jeschke

2014

Nut in Clin Prac

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Thermal injury is a devastating injury that results in a number of pathological alterations in almost every system in the body. Hypermetabolism, muscle wasting, depressed immunity, and impaired wound healing are all clinical features of burns. Failure to address each of these specific pathological alterations can lead to increased mortality. Nutrition supplementation has been recommended as a therapeutic tool to help attenuate the hypermetabolism and devastating catabolism evident following burn. Despite the wide consensus on the need of nutrition supplementation in burn patients, controversy exists with regard to the type and amount of nutrition recommended. Nutrition alone is also not enough in these patients to halt and reverse some of the damage done by the catabolic pathways activated following severe burn injury. This has led to the use of anabolic pharmacologic agents in conjunction with nutrition to help improve patient outcome following burn injury. In this review, we examine the relevant literature on nutrition after burn injury and its contribution to the attenuation of the postburn hypermetabolic response, impaired wound healing, and suppressed immunological responses. We also review the commonly used anabolic agents clinically in the care of burn patients. Finally, we provide nutrition and pharmacological recommendations gained from prospective trials, retrospective analyses, and expert opinions based on our practice at the Ross Tilley Burn Center in Toronto, Canada.

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“…Oxandrolone has been shown to improve lean muscle mass and net protein balance during the catabolic phase after severe burns and accelerates wound healing shortening lengths of hospital admission [5], [12], [13]. Despite the widespread acceptance in the literature of the use of oxandrolone as part of a severe burns treatment regime, its widespread use continues to meet reservation, as is the case in Germany.…”

Section: Introductionmentioning

confidence: 99%

A ’metabolic bundle‘ including Oxandrolone in optimising the metabolic status of severely burn injured patients: a retrospective analysis of the first 50 patients

Taha

Steinke

Fischer

et al. 2019

GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW; 8:Doc17

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The impact of oxandrolone on length of stay following major burn injury: A clinical practice evaluation

Cited by 18 publications

References 14 publications

Anabolic and anticatabolic agents used in burn care: What is known and what is yet to be learned

Anabolic and anticatabolic agents used in burn care: What is known and what is yet to be learned

Nutrition and Anabolic Pharmacotherapies in the Care of Burn Patients

A ’metabolic bundle‘ including Oxandrolone in optimising the metabolic status of severely burn injured patients: a retrospective analysis of the first 50 patients

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