The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases

Miralles, Francisco; Méhats, Céline; Vaiman, Daniel

doi:10.3390/antiox11010106

Cited by 24 publications

(13 citation statements)

References 164 publications

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“…Recent works have shown that patients with a first episode of psychosis show a reduced antioxidant status along with a marked increase in oxidative markers [22,40]. The environment in which the mother lives exposes the placental tissue to a set of chemical, physical and biological agents of OS, which may have pathological consequences in this organ [41]. OS plays a central role in placental development and can be normally observed during nonpathological pregnancies; however, an exacerbated oxidative environment may damage cellular proteins, lipids and DNA, hence impairing placental function and interrupting maternofetal communication [42].…”

Section: Discussionmentioning

confidence: 99%

“…Exclusion criteria were: meeting the diagnostic criteria for another Axis-I mental disorder or intellectual disability; or a history of neurodevelopmental disorders or head injury with loss of consciousness. The median age in the FE-PW group was 33.5 years, and the median gestational age was 40 (38)(39)(40)(41) weeks. For HC-PW, the median age was 33.5 (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39) years, and the median gestational age was 40 (39)(40)(41)(42) weeks.…”

Section: Methodsmentioning

confidence: 99%

“…The median age in the FE-PW group was 33.5 years, and the median gestational age was 40 (38)(39)(40)(41) weeks. For HC-PW, the median age was 33.5 (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39) years, and the median gestational age was 40 (39)(40)(41)(42) weeks. The sociodemographic and clinical features of these patients are summarized in Table 1.…”

Section: Methodsmentioning

confidence: 99%

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Evidence of Increased Oxidative Stress in the Placental Tissue of Women Who Suffered an Episode of Psychosis during Pregnancy

et al. 2023

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Psychosis is a complex clinical syndrome resulting in a loss of contact with reality and alterations in behavior and sensorial and motor functions. Although the onset of psychosis can be related to any medical condition, most cases of psychosis are not fully understood. Psychosis may manifest for the first time during pregnancy, which is detrimental to maternofetal well-being. The impact of having a first episode of psychosis during pregnancy on the placenta has not yet been explored. Oxidative stress is thought to take part in the etiopathogenesis of this complex disorder, and this condition can also affect the placenta as it is highly sensitive to changes in the maternal environment. In this sense, the aim of the present work was to study the gene and protein expression through RT–qPCR and immunohistochemistry, respectively, of oxidative stress markers (NOX-1, NOX-2, iNOS, eNOS and PARP) in the placental tissue of women who underwent a first episode of psychosis during pregnancy (FE-PW) in comparison to healthy pregnant women. Our results showed augmented gene and protein expression of NOX-1, NOX-2, iNOS and PARP in the placental tissue of FE-PW. For the first time, we demonstrated that oxidative stress may have an important pathophysiological role in this tissue, aiding in explaining the impact of psychosis on pregnancy and the need for future studies in this field to guide better clinical management of these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Evidence of Increased Oxidative Stress in the Placental Tissue of Women Who Suffered an Episode of Psychosis during Pregnancy

et al. 2023

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“…has not yet been established, a hypothesis of oxidative stress is emerging. There are various sources of oxidative stress in pregnancy, including exposure to metals such as cadmium, mercury, methylmercury, lead, and chromium; tobacco; airborne particulate matter; and plastics (33). Previous studies found that inhalation of particulate matter affects oxidative stress generation and causes systemic in ammation, vascular dysfunction, atherosclerosis, and cardiovascular disease in non-pregnant populations (33,34).…”

Section: Discussionmentioning

confidence: 99%

Effects of PM 2.5 exposure on metabolic dysfunction during pregnancy via personalized measurement of pollutant concentration in South Korea: A multicenter prospective cohort, air pollution on pregnancy outcome (APPO) study

Jeong

Park

Kwon

et al. 2022

Preprint

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Background Ambient particulate matter (PM) is a trigger factor for metabolic dysfunction. This study aimed to evaluate the associations between PM exposure and metabolic dysfunction in pregnancy. Methods This prospective, multicentre, observational, cohort study was conducted from January 2021 to June 2022. A total of 333 women with singleton pregnancies were recruited. For individual measurement of PM2.5 levels, an AirguardK® was installed inside the participants’ houses. Time-activity logs were recorded to predict each participant’s personal exposure to PM2.5. The participants were divided into groups according to the concentration of PM2.5 calculated by a time-weighted average model. We used the Student t-test and chi-squared test (or Fisher’s exact test) to evaluate changes in metabolic compound levels, blood pressure (BP), glucose intolerance, and lipid profiles, including serum triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratios. Logistic and linear regression models were used to analyse the association between PM2.5 exposure and metabolic dysfunction, using odds ratios (ORs) and 95% confidence intervals (CIs). Results PM2.5 exposure during pregnancy worsened metabolic dysfunction. Third trimester BP was elevated in those participants exposed to higher levels of PM2.5 (p <0.05). The incidence of gestational diabetes mellitus (GDM) was constantly higher in those exposed to more PM2.5, regardless of the PM2.5 cut-off level (PM2.5 ≥10 µg/m3, 7.91 % vs. 16.09 %, p <0.05; PM2.5 ≥25 µg/m3, 7.91 % vs. 26.67 %, p <0.05). The proportion with a TG/HDL-C ratio ≥3.0 was significantly higher when PM2.5 was ≥10 µg/m3 (75.3 % vs. 83.0 %, p <0.05). Triglyceride levels were significantly higher in the PM2.5 ≥25 µg/m3 group (p=0.0171). We found an increased risk of elevated BP (adjusted OR [aOR]: 2.228, 95% CI: 1.115–4.449) and GDM (aOR 2.263, 95% CI 1.106–5.039) in the third trimester after adjusting for confounders. Conclusion Exposure to PM2.5 worsens metabolic dysfunction in pregnancy. Further studies are required to investigate the mechanisms by which ambient PM affects metabolic dysfunction in pregnancy.

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“…A body of evidence has suggested that oxidative stress operates through multiple mechanisms to adversely affect a number of target organs and systems leading to various disease states. Such diseases include placental diseases (Ruano et al, 2022), atherosclerosis, chronic obstructive pulmonary disease, Alzheimer's disease, and cancer (Forman and Zhang, 2021). It is also worthy of note that the degree to which oxidative stress participates in the pathology of diseases varies greatly, such that the effectiveness of increasing antioxidant defence may be limited in some diseases (Forman and Zhang, 2021).…”

Section: The Concept Of Oxidative Stress and Its Pathophysiologymentioning

confidence: 99%

Environmental Pollutants and Oxidative Stress in Terrestrial and Aquatic Organisms: Examination of the Total Picture and Implications for Human Health

et al. 2022

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There is current great international concern about the contribution of environmental pollution to the global burden of disease particularly in the developing, low- and medium-income countries. Industrial activities, urbanization, developmental projects as well as various increased anthropogenic activities involving the improper generation, management and disposal of pollutants have rendered today’s environment highly polluted with various pollutants. These pollutants include toxic metals (lead, cadmium, mercury, arsenic), polycyclic aromatic hydrocarbons, polychlorinated biphenyls, pesticides and diesel exhaust particles most of which appear to be ubiquitous as well as have long-term environmental persistence with a wide range of toxicities such as oxidative stress among others. Oxidative stress, which may arise from increased production of damaging free radicals emanating from increased pollutant burden and depressed bioavailability of antioxidant defenses causes altered biochemical and physiological mechanisms and has been implicated in all known human pathologies most of which are chronic. Oxidative stress also affects both flora and fauna and plants are very important components of the terrestrial environment and significant contributors of nutrients for both man and animals. It is also remarkable that the aquatic environment in which sea animals and creatures are resident is also highly polluted, leading to aquatic stress that may affect the survival of the aquatic animals, sharing in the oxidative stress. These altered terrestrial and aquatic environments have an overarching effect on human health. Antioxidants neutralize the damaging free radicals thus, they play important protective roles in the onset, progression and severity of the unmitigated generation of pollutants that ultimately manifest as oxidative stress. Consequently, human health as well as that of aquatic and terrestrial organisms may be protected from environmental pollution by mitigating oxidative stress and employing the principles of nutritional medicine, essentially based on antioxidants derived mainly from plants, which serve as the panacea of the vicious state of environmental pollutants consequently, the health of the population. Understanding the total picture of oxidative stress and integrating the terrestrial and aquatic effects of environmental pollutants are central to sustainable health of the population and appear to require multi-sectoral collaborations from diverse disciplinary perspectives; basically the environmental, agricultural and health sectors.

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The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases

Cited by 24 publications

References 164 publications

Evidence of Increased Oxidative Stress in the Placental Tissue of Women Who Suffered an Episode of Psychosis during Pregnancy

Evidence of Increased Oxidative Stress in the Placental Tissue of Women Who Suffered an Episode of Psychosis during Pregnancy

Effects of PM 2.5 exposure on metabolic dysfunction during pregnancy via personalized measurement of pollutant concentration in South Korea: A multicenter prospective cohort, air pollution on pregnancy outcome (APPO) study

Environmental Pollutants and Oxidative Stress in Terrestrial and Aquatic Organisms: Examination of the Total Picture and Implications for Human Health

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