The impact of paced QRS duration on the expression of genes related to contractile function of the left ventricle in chronically paced patients from the right ventricular apex

Simantirakis, Emmanuel N.; Arkolaki, Eva G.; Kontaraki, Joanna; Chlouverakis, Gregory; Mavrakis, Hercules E.; Kallergis, E. M.; Parthenakis, Fragiskos I.; Vardas, Panos

doi:10.1016/j.hjc.2019.04.011

Cited by 3 publications

(4 citation statements)

References 25 publications

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“…Pathological and increased LV excitation seem to affect ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 gene (SERCA2) expression, which regulates cardiac contractility [ 28 ]. A previous study indicated that the duration of paced QRS complexes is correlated with changes in SERCA2 expression, which precede the decline in LV function and adverse remodeling in patients undergoing permanent pacemaker implantation [ 28 ]. Specifically, as paced QRS duration increases, there is a significant reduction in SERCA2 expression, which serves as an indicator of LV function.…”

Section: Transcriptional Regulation and Gene Expression Modulation Du...mentioning

confidence: 99%

“…In a recent study by Simantirakis et al, SERCA2 , MYH genes (encoding α- and β- myosin heavy chains (MHC), proteins that regulate myocardial contractile function and hypertrophy were observed to alter after examining peripheral blood mRNA levels in patients with long-term RVAP. SERCA2 and MYH6 gene expressions were decreased in comparison to MYH7 , which was increased until 6 months follow-up [ 28 ]. In a cohort of 52 consecutive patients who underwent pacemaker implantation for bradycardic indications, 25% of patients demonstrated significant LV remodeling.…”

Section: Transcriptional Regulation and Gene Expression Modulation Du...mentioning

confidence: 99%

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Cardiac Remodeling and Ventricular Pacing: From Genes to Mechanics

Malikides,

Simantirakis,

Zacharis

et al. 2024

Genes

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Cardiac remodeling and ventricular pacing represent intertwined phenomena with profound implications for cardiovascular health and therapeutic interventions. This review explores the intricate relationship between cardiac remodeling and ventricular pacing, spanning from the molecular underpinnings to biomechanical alterations. Beginning with an examination of genetic predispositions and cellular signaling pathways, we delve into the mechanisms driving myocardial structural changes and electrical remodeling in response to pacing stimuli. Insights into the dynamic interplay between pacing strategies and adaptive or maladaptive remodeling processes are synthesized, shedding light on the clinical implications for patients with various cardiovascular pathologies. By bridging the gap between basic science discoveries and clinical translation, this review aims to provide a comprehensive understanding of cardiac remodeling in the context of ventricular pacing, paving the way for future advancements in cardiovascular care.

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Section: Transcriptional Regulation and Gene Expression Modulation Du...mentioning

confidence: 99%

Section: Transcriptional Regulation and Gene Expression Modulation Du...mentioning

confidence: 99%

Cardiac Remodeling and Ventricular Pacing: From Genes to Mechanics

Malikides,

Simantirakis,

Zacharis

et al. 2024

Genes

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“…Particularly, it has been shown that gene expression changes in the peripheral blood of IDCM patients can reflect changes in left ventricular function [ 16 ]. In addition, several reports have indicated that gene expression alterations in blood cells occur in the early stages of the disease and before the condition worsens [ 17 , 18 , 19 , 20 ]. Considering that aberrant molecular variations and environmental modifications leading to cardiovascular disease occur before tissue morphological abnormalities [ 21 ], the study of molecular variations can serve as a valuable tool for the early diagnosis of asymptomatic patients.…”

Section: Introductionmentioning

confidence: 99%

CCND1 Overexpression in Idiopathic Dilated Cardiomyopathy: A Promising Biomarker?

Dehghani,

Stanek,

Bagherabadi

et al. 2023

Genes

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Cardiomyopathy, a disorder of electrical or heart muscle function, represents a type of cardiac muscle failure and culminates in severe heart conditions. The prevalence of dilated cardiomyopathy (DCM) is higher than that of other types (hypertrophic cardiomyopathy and restrictive cardiomyopathy) and causes many deaths. Idiopathic dilated cardiomyopathy (IDCM) is a type of DCM with an unknown underlying cause. This study aims to analyze the gene network of IDCM patients to identify disease biomarkers. Data were first extracted from the Gene Expression Omnibus (GEO) dataset and normalized based on the RMA algorithm (Bioconductor package), and differentially expressed genes were identified. The gene network was mapped on the STRING website, and the data were transferred to Cytoscape software to determine the top 100 genes. In the following, several genes, including VEGFA, IGF1, APP, STAT1, CCND1, MYH10, and MYH11, were selected for clinical studies. Peripheral blood samples were taken from 14 identified IDCM patients and 14 controls. The RT-PCR results revealed no significant differences in the expression of the genes APP, MYH10, and MYH11 between the two groups. By contrast, the STAT1, IGF1, CCND1, and VEGFA genes were overexpressed in patients more than in controls. The highest expression was found for VEGFA, followed by CCND1 (p < 0.001). Overexpression of these genes may contribute to disease progression in patients with IDCM. However, more patients and genes need to be analyzed in order to achieve more robust results.

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“…The evidence suggests that RV pacing may result in alterations to the genetic expression of components of the sarcoplasmic reticulum which precede a decline in LV function [ 18 ]. Endomyocardial biopsies from patients subjected to long-term ventricular pacing have revealed alterations at the cellular and subcellular levels, including differences in fibrosis, fat deposition and mitochondrial morphological changes [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Pacemaker Induced Cardiomyopathy: An Overview of Current Literature

Gavaghan

2022

CCR

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: Pacemaker induced cardiomyopathy (PICM) is commonly defined as a reduction in left ventricular (LV) function in the setting of right ventricular (RV) pacing. This condition may be associated with the onset of clinical heart failure in those affected. Recent studies have focused on potential methods of identifying patients at risk of this condition, in addition to hypothesizing the most efficacious ways to manage these patients. Newer pacing options, such as His bundle pacing, may avoid the onset of PICM entirely.

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The impact of paced QRS duration on the expression of genes related to contractile function of the left ventricle in chronically paced patients from the right ventricular apex

Cited by 3 publications

References 25 publications

Cardiac Remodeling and Ventricular Pacing: From Genes to Mechanics

Cardiac Remodeling and Ventricular Pacing: From Genes to Mechanics

CCND1 Overexpression in Idiopathic Dilated Cardiomyopathy: A Promising Biomarker?

Pacemaker Induced Cardiomyopathy: An Overview of Current Literature

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