The impact of parity on life course blood pressure trajectories: the HUNT study in Norway

Haug, E; Horn, Julie; Markovitz, Amanda R; Fraser, Abigail; Macdonald‐Wallis, Corrie; Tilling, Kate; Romundstad, Pål Richard; Rich‐Edwards, Janet W.; Åsvold, Bjørn Olav

doi:10.1007/s10654-018-0358-z

Cited by 21 publications

(18 citation statements)

References 43 publications

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“…In our previous analysis on parity and life course blood pressure trajectories from this cohort, we observed that women with HDP as a group had higher blood pressure from before first pregnancy until beyond 60 years of age 18. In the present study, we examined a wide range of cardiovascular risk factors separately among women with preeclampsia and gestational hypertension.…”

Section: Discussionmentioning

confidence: 73%

“…In the HUNT (Nord‐Trøndelag Health Study) cohort in Norway, we recently observed that higher blood pressure in women with a history of HDP manifests before first pregnancy and lasts beyond 60 years of age 18. In the present study, we examine the life course trajectories from before first pregnancy and until 60 years of age for a broad range of cardiovascular risk factors in women with and without HDP in their first pregnancy.…”

Section: Introductionmentioning

confidence: 96%

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Life Course Trajectories of Cardiovascular Risk Factors in Women With and Without Hypertensive Disorders in First Pregnancy: The HUNT Study in Norway

Haug

Horn

Markovitz

et al. 2018

JAHA

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BackgroundWomen with hypertensive pregnancy disorders have adverse levels of cardiovascular risk factors. It is unclear how this adverse risk factor profile evolves during adult life. We compared life course trajectories of cardiovascular risk factors in women with preeclampsia or gestational hypertension in their first pregnancy to normotensive women.Methods and ResultsWe linked information on cardiovascular risk factors from the population‐based HUNT (Nord‐Trøndelag Health Study) surveys with pregnancy information from the Medical Birth Registry of Norway. Trajectories of cardiovascular risk factors were constructed for 22 308 women with a normotensive first pregnancy; 1092 with preeclampsia, and 478 with gestational hypertension in first pregnancy. Already before first pregnancy, women with preeclampsia in their first pregnancy had higher measures of adiposity, blood pressure, heart rate, and serum lipids and glucose compared with women with a normotensive first pregnancy. After first pregnancy, there was a parallel development in cardiovascular risk factor levels, but women with a normotensive first pregnancy had a time lag of >10 years compared with the preeclampsia group. There were no clear differences in risk factor trajectories between women with gestational hypertension and women with preeclampsia.ConclusionsWomen with hypertensive pregnancy disorders in their first pregnancy had an adverse cardiovascular risk factor profile before pregnancy compared with normotensive women, and the differences persisted beyond 50 years of age. Hypertensive disorders in pregnancy signal long‐term increases in modifiable cardiovascular risk factors, and may be used to identify women who would benefit from early prevention strategies.

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Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 96%

Life Course Trajectories of Cardiovascular Risk Factors in Women With and Without Hypertensive Disorders in First Pregnancy: The HUNT Study in Norway

Haug

Horn

Markovitz

et al. 2018

JAHA

Self Cite

View full text Add to dashboard Cite

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“…For additional EJE references please see [142][143][144][145][146][147][148][149][150][151][152][153][154][155][156][157][158][159][160].…”

Section: Main Results In the Last 3 Yearsunclassified

Objectives, design and main findings until 2020 from the Rotterdam Study

et al. 2020

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The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical course, natural history and potential targets for intervention for chronic diseases in mid-life and late-life. The study focuses on cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1700 research articles and reports. This article provides an update on the rationale and design of the study. It also presents a summary of the major findings from the preceding 3 years and outlines developments for the coming period.

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“…[16][17][18] Moreover, findings from prospective studies on this issue, all conducted in Western countries, were also limited and inconclusive. 6,[19][20][21] The current study aims at determining whether the live birth/parity number is an independent risk factor for hypertension development among Iranian women aged 30-70 years, with 13.5 years of follow-up, using a population-based cohort, the Tehran Lipid and Glucose Study (TLGS).…”

mentioning

confidence: 99%

Live birth/parity number and the risk of incident hypertension among parous women during over 13 years of follow‐up

Moazzeni

Asgari

Azizi

et al. 2021

J of Clinical Hypertension

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The effect of live birth/parity number on incident hypertension was investigated among Iranian parous women aged 30-70 years. The study population included 2188 normotensive women who were enrolled in 1999-2001. They were followed for incident hypertension (based on JNC 7 report) by 3-year intervals up to April 2018. Multivariable Cox proportional hazard models, adjusted for a wide set of potential hypertension risk factors, reproductive factors, and pregnancy complications, were applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of the number of parity/live birth(s) for incident hypertension. Additionally, as a sensitivity analysis, agescale Cox regression was also done. During a median follow-up of 13.5 years, 935 incident hypertension have occurred. Compared to those with two live births, the participants who had 3 and ≥4 live births were at higher risk of hypertension development by the HRs of 1.25 [95% CI: 1.02-1.55] and 1.39 [1.12-1.72], respectively, in the fulladjusted model. Moreover, each additional live birth increased the risk of hypertension by a HR of 1.06 [95%CI: 1.02-1.11]. Results of parity number were also similar. Considering age as time scale also did not change the results generally. The authors found a significant interaction between live birth/parity number and age groups; the adverse effect of higher live birth/parity numbers on hypertension development was mainly found among those aged < 50 years. To sum up, compared to the live birth/parity number of two, Iranian women with ≥3 live birth/parity had a higher risk of incident hypertension; the issue was more prominent among younger mothers.

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The impact of parity on life course blood pressure trajectories: the HUNT study in Norway

Cited by 21 publications

References 43 publications

Life Course Trajectories of Cardiovascular Risk Factors in Women With and Without Hypertensive Disorders in First Pregnancy: The HUNT Study in Norway

Life Course Trajectories of Cardiovascular Risk Factors in Women With and Without Hypertensive Disorders in First Pregnancy: The HUNT Study in Norway

Objectives, design and main findings until 2020 from the Rotterdam Study

Live birth/parity number and the risk of incident hypertension among parous women during over 13 years of follow‐up

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