The impact of past alcohol use on treatment response rates in patients with chronic hepatitis C

Chang, Alan W.; Skole, Kevin; Gautam, Mamta; Schmutz, Joan K; Black, Martin M.; Thomas, Rebecca; Horwitz, Brenda; Friedenberg, Frank K.

doi:10.1111/j.1365-2036.2005.02631.x

Cited by 23 publications

(19 citation statements)

References 15 publications

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“…Most studies found that alcohol decreased the response to interferon-based therapy and this effect is alcohol dosedependent [42][43][44] . Median daily alcohol use > 30 g/d is associated with failure to respond to PEG-IFN and RBV for treatment of hepatitis C. Past alcohol use should be evaluated when considering treatment for hepatitis C [42] . Management: Stop alcohol abuse, intestinal antibiotics and probiotics to prevent gut endotoxin formation; and antioxidants as vitamin E, betaine and silymarin to block lipid peroxidation.…”

Section: Alcohol Abusementioning

confidence: 99%

“…It plays a role in resistance to interferon therapy through immunosuppression of CD4+ and NK cells [41] , by increased hepatic iron load, and by inhibiting the IFN-α-activated signals [42,43] . Most studies found that alcohol decreased the response to interferon-based therapy and this effect is alcohol dosedependent [42][43][44] . Median daily alcohol use > 30 g/d is associated with failure to respond to PEG-IFN and RBV for treatment of hepatitis C. Past alcohol use should be evaluated when considering treatment for hepatitis C [42] .…”

Section: Alcohol Abusementioning

confidence: 99%

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Hepatitis C comorbidities affecting the course and response to therapy

El-Zayadi¹

2009

WJG

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Several studies have demonstrated that the outcome of chronic hepatitis C (CHC) infection is profoundly influenced by a variety of comorbidities. Many of these comorbidities have a significant influence on the response to antiviral therapy. These comorbidities negatively affect the course and outcome of liver disease, often reducing the chance of achieving a sustained virological response with PEGylated interferon and ribavirin treatments. Comorbidities affecting response to antiviral therapy reduce compliance and adherence to inadequate doses of therapy. The most important comorbidities affecting the course of CHC include hepatitis B virus coinfection, metabolic syndrome, and intestinal bacterial overgrowth. Comorbidities affecting the course and response to therapy include schistosomiasis, iron overload, alcohol abuse, and excessive smoking. Comorbidities affecting response to antiviral therapy include depression, anemia, cardiovascular disease, and renal failure.

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Section: Alcohol Abusementioning

confidence: 99%

Section: Alcohol Abusementioning

confidence: 99%

Hepatitis C comorbidities affecting the course and response to therapy

El-Zayadi¹

2009

WJG

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“…A direct relationship has been shown between alcohol and the response to interferon (IFN) therapy (13). Several studies have indicated that the response to interferon is decreased in patients with alcoholism (82)(83)(84)(85)(86). In HCV infected patients, the IFN response is influenced by two factors, ethanol intake and HCV RNA levels.…”

Section: Alcohol Consumption and Impact On Antihepatitis C Virus Therapymentioning

confidence: 99%

New Insights Into the Relationships Among Alcohol Consumption, Hepatocellular Carcinoma and Hepatitis C Virus Infection

Ghannad¹,

Mohammadi²,

Kazemian³

2014

Avicenna J Clin Microbiol Infect

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Context: Viral hepatitis and the consumption of alcohol are recognized as important reasons for the development of liver disease throughout the world. It would also seem that chronic alcoholism causes more severe and rapid progression of liver disease in patients with chronic hepatitis C, leading to more frequent liver cirrhosis and hepatocellular carcinoma. Evidence Acquisition: The data for this article were obtained through an initial Medline search and from the references of relevant articles, and used to provide updated information on the relationship between alcohol consumption and the hepatitis C virus. Results: Excessive alcohol consumption among patients with chronic hepatitis C is likely to result in more severe hepatic injuries, promote pathologic progression to cirrhosis, and increase the risk of developing hepatocellular carcinoma. Although the exact mechanisms involved in the progression of chronic hepatitis C in alcoholic patients have not been definitely established, possible alcohol-induced enhancement of viral replication, iron overload, immunologic suppression, the role of NF-kappa B, and the signaling pathways involved in its activation, have been suggested. Significant correlations have been reported between hepatitis C virus RNA levels and the amount of alcohol consumed by an individual. Interferon therapy is less effective for alcohol patients, than non-alcoholic patients, even after a period of abstinence. The obtained data suggest that a hepatitis C virus infection is an important cofactor in the pathogenesis of liver disease among patients with an alcohol problem. Conclusions: In light of a possible synergistic effect between alcohol and hepatitis C virus replication, total abstention ought to be recommended, and due to alcohol's inhibitory effect on interferon therapy, patients with alcohol problems should not be treated until they stop drinking.Keywords:Hepatitis C; Carcinoma, Hepatocellular; Alcohols; Interferons Implication for health policy/practice/research/medical education: Chronic alcoholism in patients with chronic hepatitis C appears to cause more severe and rapidly progressive liver disease, leading more frequently to liver cirrhosis and HCC. In conclusion, patients with chronic hepatitis C should limit their alcohol intake and if cirrhosis is present or interferon therapy is planned, complete avoidance from alcohol should be encouraged.

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“…Nunes and colleagues (2006) suggested that active alcohol use was a major barrier to HCV treatment in HIV/HCV coinfected adults. Excessive alcohol use Substance Use and HCV Decision-Making 917 has also been associated with early HCV treatment discontinuation (Anand et al, 2006) and a reduced response rate to HCV treatment (Bhattacharya and Shuhart, 2003;Chang et al, 2005;Torriani et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

HCV Treatment Decision-Making Substance Use Experiences and Hepatitis C Treatment Decision-Making Among HIV/HCV Coinfected Adults

Ogawa

Bova

2009

Substance Use & Misuse

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Hepatitis C virus (HCV) infection is a major source of morbidity and mortality among substance users and persons living with human immunodeficiency virus (HIV) infection. Treatment for chronic HCV infection involves complex decision-making. These decisions are even more complicated in persons with HIV and substance use related problems. A secondary analyses of qualitative data collected in the United States (2004-2005) with 31 HIV/HCV coinfected adults (48% women; mean age 44.7 years) revealed three themes related to substance use (substance use evolution, revolving door: going back out and reconstructing life) and two HCV treatment decision-making themes (HCV infection treatment issues: not a priority, fear, misinformation and get clean and try it). Study limitations and implications are discussed.

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The impact of past alcohol use on treatment response rates in patients with chronic hepatitis C

Cited by 23 publications

References 15 publications

Hepatitis C comorbidities affecting the course and response to therapy

Hepatitis C comorbidities affecting the course and response to therapy

New Insights Into the Relationships Among Alcohol Consumption, Hepatocellular Carcinoma and Hepatitis C Virus Infection

HCV Treatment Decision-Making Substance Use Experiences and Hepatitis C Treatment Decision-Making Among HIV/HCV Coinfected Adults

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