The impact of patient preference in the treatment algorithm for recurrent/metastatic head and neck squamous cell carcinoma

Salvestrini, Viola; Becherini, Carlotta; Desideri, Isacco; Caprara, Luisa; Mariotti, Matteo; Banini, Marco; Pierossi, Nicola; Scotti, Vieri; Livi, Lorenzo; Bonomo, Pierluigi

doi:10.1007/s11547-022-01509-1

Cited by 6 publications

(3 citation statements)

References 43 publications

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“…Radiomics models [ 123 , 124 ] showed an excellent correspondence with pathologists’ assessment on postoperative specimens or preoperative biopsy, which are hampered by being invasive and not automatically representative of the whole lesion. The possibility to capture the complex intratumoral heterogeneity is an important tool in intercepting the tumor’s overall biological behavior [ 125 , 126 , 127 , 128 , 129 ]. From a clinical perspective, these open up the possibility to select patients and guide the right treatment choice, allowing a more personalized approach.…”

Section: Resultsmentioning

confidence: 99%

Prognostic Assessment of Gastropancreatic Neuroendocrine Neoplasm: Prospects and limits of Radiomics

De Muzio,

Pellegrino,

Fusco

et al. 2023

Diagnostics

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Neuroendocrine neoplasms (NENs) are a group of lesions originating from cells of the diffuse neuroendocrine system. NENs may involve different sites, including the gastrointestinal tract (GEP-NENs). The incidence and prevalence of GEP-NENs has been constantly rising thanks to the increased diagnostic power of imaging and immuno–histochemistry. Despite the plethora of biochemical markers and imaging techniques, the prognosis and therapeutic choice in GEP-NENs still represents a challenge, mainly due to the great heterogeneity in terms of tumor lesions and clinical behavior. The concept that biomedical images contain information about tissue heterogeneity and pathological processes invisible to the human eye is now well established. From this substrate comes the idea of radiomics. Computational analysis has achieved promising results in several oncological settings, and the use of radiomics in different types of GEP-NENs is growing in the field of research, yet with conflicting results. The aim of this narrative review is to provide a comprehensive update on the role of radiomics on GEP-NEN management, focusing on the main clinical aspects analyzed by most existing reports: predicting tumor grade, distinguishing NET from other tumors, and prognosis assessment.

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Section: Resultsmentioning

confidence: 99%

Prognostic Assessment of Gastropancreatic Neuroendocrine Neoplasm: Prospects and limits of Radiomics

De Muzio,

Pellegrino,

Fusco

et al. 2023

Diagnostics

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“…HPV-related cancer usually presents itself as an exophytic lesion with well-defined borders and little to no invasion of the submucosa or of the adjacent tissues, such as muscle [ 13 , 29 – 32 ] (Fig. 2 ).…”

Section: Diagnostic Role Of Computed Tomographymentioning

confidence: 99%

Imaging of human papilloma virus (HPV) related oropharynx tumour: what we know to date

Bicci,

Calamandrei,

Mungai

et al. 2023

Infect Agents Cancer

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The tumours of head and neck district are around 3% of all malignancies and squamous cell carcinoma is the most frequent histotype, with rapid increase during the last two decades because of the increment of the infection due to human papilloma virus (HPV). Even if the gold standard for the diagnosis is histological examination, including the detection of viral DNA and transcription products, imaging plays a fundamental role in the detection and staging of HPV + tumours, in order to assess the primary tumour, to establish the extent of disease and for follow-up. The main diagnostic tools are Computed Tomography (CT), Positron Emission Tomography-Computed Tomography (PET-CT) and Magnetic Resonance Imaging (MRI), but also Ultrasound (US) and the use of innovative techniques such as Radiomics have an important role. Aim of our review is to illustrate the main imaging features of HPV + tumours of the oropharynx, in US, CT and MRI imaging. In particular, we will outline the main limitations and strengths of the various imaging techniques, the main uses in the diagnosis, staging and follow-up of disease and the fundamental differential diagnoses of this type of tumour. Finally, we will focus on the innovative technique of texture analysis, which is increasingly gaining importance as a diagnostic tool in aid of the radiologist.

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“…Low anterior resection (LAR) is a sphincter-sparing TME technique. Although definitive colostomy could be avoided, up to 90% of patients following the procedure could experience disabling symptoms of the so-called LAR syndrome, that drastically reduce the quality of life [ 13 , 14 ]. Therefore, less-invasive strategies have been tested in order to mitigate the morbidity of rectal resection, while providing acceptable oncologic results, particularly for early-stage RC.…”

Section: Introductionmentioning

confidence: 99%

Post-Surgical Imaging Assessment in Rectal Cancer: Normal Findings and Complications

Muzio

Fusco

Cutolo

et al. 2023

JCM

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Rectal cancer (RC) is one of the deadliest malignancies worldwide. Surgery is the most common treatment for RC, performed in 63.2% of patients. The type of surgical approach chosen aims to achieve maximum residual function with the lowest risk of recurrence. The selection is made by a multidisciplinary team that assesses the characteristics of the patient and the tumor. Total mesorectal excision (TME), including both low anterior resection (LAR) and abdominoperineal resection (APR), is still the standard of care for RC. Radical surgery is burdened by a 31% rate of major complications (Clavien–Dindo grade 3–4), such as anastomotic leaks and a risk of a permanent stoma. In recent years, less-invasive techniques, such as local excision, have been tested. These additional procedures could mitigate the morbidity of rectal resection, while providing acceptable oncologic results. The “watch and wait” approach is not a globally accepted model of care but encouraging results on selected groups of patients make it a promising strategy. In this plethora of treatments, the radiologist is called upon to distinguish a physiological from a pathological postoperative finding. The aim of this narrative review is to identify the main post-surgical complications and the most effective imaging techniques.

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The impact of patient preference in the treatment algorithm for recurrent/metastatic head and neck squamous cell carcinoma

Cited by 6 publications

References 43 publications

Prognostic Assessment of Gastropancreatic Neuroendocrine Neoplasm: Prospects and limits of Radiomics

Prognostic Assessment of Gastropancreatic Neuroendocrine Neoplasm: Prospects and limits of Radiomics

Imaging of human papilloma virus (HPV) related oropharynx tumour: what we know to date

Post-Surgical Imaging Assessment in Rectal Cancer: Normal Findings and Complications

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