The impact of patients' real-life environmental temperature and humidity use conditions of tiotropium dry powder inhaler on its aerosol emission characteristics

Ammari, Wesam G.; Mohammad, Mohammad Khalil; Tayyem, Rabab

doi:10.1016/j.ejps.2019.04.002

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…Because an MMAD below 5 µm is typically assumed to be necessary for deposition in the lower airways [ 83 ], it is concluded that all three rod formulations will reach the pertinent targets. Moreover, the efficacy of these particles is comparable to commercial DPI formulations using the HandiHaler ® [ 84 , 85 ] while being able to deliver higher amounts of API due to the larger volume of the delivery system.…”

Section: Resultsmentioning

confidence: 97%

Aspherical, Nano-Structured Drug Delivery System with Tunable Release and Clearance for Pulmonary Applications

Pioch,

Fischer,

Schneider

2024

Pharmaceutics

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Addressing the challenge of efficient drug delivery to the lungs, a nano-structured, microparticulate carrier system with defined and customizable dimensions has been developed. Utilizing a template-assisted approach and capillary forces, particles were rapidly loaded and stabilized. The system employs a biocompatible alginate gel as a stabilizing matrix, facilitating the breakdown of the carrier in body fluids with the subsequent release of its nano-load, while also mitigating long-term accumulation in the lung. Different gel strengths and stabilizing steps were applied, allowing us to tune the release kinetics, as evaluated by a quantitative method based on a flow-imaging system. The micro-cylinders demonstrated superior aerodynamic properties in Next Generation Impactor (NGI) experiments, such as a smaller median aerodynamic diameter (MMAD), while yielding a higher fine particle fraction (FPF) than spherical particles similar in critical dimensions. They exhibited negligible toxicity to a differentiated macrophage cell line (dTHP-1) for up to 24 h of incubation. The kinetics of the cellular uptake by dTHP-1 cells was assessed via fluorescence microscopy, revealing an uptake-rate dependence on the aspect ratio (AR = l/d); cylinders with high AR were phagocytosed more slowly than shorter rods and comparable spherical particles. This indicates that this novel drug delivery system can modulate macrophage uptake and clearance by adjusting its geometric parameters while maintaining optimal aerodynamic properties and featuring a biodegradable stabilizing matrix.

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Section: Resultsmentioning

confidence: 97%

Aspherical, Nano-Structured Drug Delivery System with Tunable Release and Clearance for Pulmonary Applications

Pioch,

Fischer,

Schneider

2024

Pharmaceutics

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“…In particular, females and younger age groups seem to be more affected by high RH and heatwaves [54]. RH below or above the recommended levels may also affect the storage stability of drugs, particularly those administered by inhalation [55]. A limited number of studies underline the positive role of humidity reduction, especially in improving work activity and reducing school absenteeism following indoor air humidification [56].…”

Section: Unhealthy Environment and Interventionsmentioning

confidence: 99%

Relative Humidity and Its Impact on the Immune System and Infections

Guarnieri

Olivieri

Senna

et al. 2023

IJMS

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Relative humidity (RH) represents an underestimated outdoor and indoor environmental parameter. Conditions below and above the optimal range could facilitate infectious transmission as well as the exacerbation of respiratory diseases. The aim of this review is to outline the consequences for health of suboptimal RH in the environment and how to limit this negative impact. RH primarily affects the rheological properties of the mucus, modifying its osmolarity and thus the mucociliary clearance. The integrity of the physical barrier, maintained by mucus and tight junctions, is critical for protection from pathogens or irritants. Moreover, the control of RH seems to be a strategy to prevent and control the spread of viruses and bacteria. However, the imbalance of RH in the outdoor and indoor environments is frequently associated with the presence of other irritants, allergens, and pathogens, and therefore the burden of a single risk factor is not clearly defined in different situations. Nonetheless, RHmay have a synergistic negative effect with these risk factors, and its normalization, if possible, may have a positive impact on a healthier environment.

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Scientific and regulatory activities initiated by the U.S. food and drug administration to foster approvals of generic dry powder inhalers: Quality perspective

El-Gendy

Bertha

El-Shafy

et al. 2022

Advanced Drug Delivery Reviews

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The impact of patients' real-life environmental temperature and humidity use conditions of tiotropium dry powder inhaler on its aerosol emission characteristics

Cited by 6 publications

References 19 publications

Aspherical, Nano-Structured Drug Delivery System with Tunable Release and Clearance for Pulmonary Applications

Aspherical, Nano-Structured Drug Delivery System with Tunable Release and Clearance for Pulmonary Applications

Relative Humidity and Its Impact on the Immune System and Infections

Scientific and regulatory activities initiated by the U.S. food and drug administration to foster approvals of generic dry powder inhalers: Quality perspective

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