2013
DOI: 10.1016/j.intimp.2012.12.012
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The impact of PEGylation on protein immunogenicity

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Cited by 42 publications
(29 citation statements)
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“…One possible explanation for the reduction in antibody immune response is the masking effect, which can be achieved by conjugation of molecules to a protein's surface . Immunization with hsIgG conjugated to MBA, MDTBA or MLA significantly reduced the antibody immune response against hsIgG.…”
Section: Discussionmentioning
confidence: 99%
“…One possible explanation for the reduction in antibody immune response is the masking effect, which can be achieved by conjugation of molecules to a protein's surface . Immunization with hsIgG conjugated to MBA, MDTBA or MLA significantly reduced the antibody immune response against hsIgG.…”
Section: Discussionmentioning
confidence: 99%
“…However, chemical modification, such as PEGylation, is largely non-specific, thus resulting in unpredictable outcomes for vaccines. For this reason, it is mainly employed to reduce therapeutic protein antigenicity (141)(142)(143)(144). Ideally, immunogen surface should be considered for each individual vaccine in order to simultaneously direct antibody-mediated immune response toward important epitopes and prevent pre-existing antibody recognition of carrier-specific immunodominant regions.…”
Section: Carrier Induced Epitopic Suppressionmentioning
confidence: 99%
“…Beside presenting the same advantages achievable for small drugs, polymer-protein conjugates can count on additional benefits linked to the shielding effect of polymer chains on the protein surface, thus reducing immunogenicity and protein aggregation [47]. These positive results are gained at the expense of protein activity that is usually reduced in conjugated forms due to the steric hindrance of polymer chains on the recognition receptors [48].…”
Section: Polymer Conjugation Of Proteinsmentioning
confidence: 99%