The Impact of Perceived Adverse Effects on Medication Changes in Heart Failure Patients

Smedt, Ruth H. E. De; Jaarsma, Tiny; Haaijer‐Ruskamp, Flora; Denig, Petra

doi:10.1016/j.cardfail.2009.09.006

Cited by 10 publications

(7 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23,24 Modification of medication prescribed by physicians in case of mild ADEs, even after multiple reporting, is shown to be relatively low (only in 38% of the cases). 4 Our results suggest that the meaning of a Bsignificant health problem[ as a justification of discontinuation or uptitration as mentioned in the European guidelines of HF treatment 1 may be put into a broader perspective including the more mild ADEs, with patients' tolerance as cutoff. There is still a low level of dialogue about Adverse Drug Events in Heart Failure 257 medication use between patients and physicians during medical encounters, 25 because not all physicians consider ADE as a concern related to clinical practice.…”

Section: Discussionmentioning

confidence: 96%

“…For example, in case of dry cough, the likelihood that medication is being changed was found to be high, greater than 80%. 4 The most common medication change was a switch from an ACE inhibitor to an angiotensin receptor blocker. When comparing this with other mild common perceived ADEs in HF such as dizziness, the initiation of medication modifications was much lower (G40%).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Perceived Adverse Drug Events in Heart Failure

Smedt

Haaijer‐Ruskamp

Groenier

et al. 2011

Journal of Cardiovascular Nursing

Self Cite

View full text Add to dashboard Cite

Background: Patients with heart failure (HF) often perceive adverse drug events (ADEs), affecting quality of life. For weighing the benefits and burden of medication in HF care, knowledge on patients' perception of ADEs is needed. Our aim was to assess these ADE perceptions and to identify factors related to these perceptions. Methods: A cross-sectional study was performed including HF patients recruited from primary care and outpatient clinics. Patients were included in the analysis if they perceived an ADE in the past 4 weeks. This information was collected using an open-ended question and a symptom checklist. Data on ADE perception were obtained using a modified version of the Revised Illness Perception Questionnaire. Demographic, clinical, and ADE characteristics were collected by self-administered questionnaire and chart review. The relations between these factors and ADE perceptions were analyzed using regression analyses. Results: In total, 261 HF patients perceived an ADE and completed the questionnaire. Patients reported 814 ADEs, of which 26% of the patients reported dizziness and 24% reported dry mouth as being the most prevalent. Almost half of the patients (46%) perceived their ADE as something serious, with major consequences for their daily life (40%) and reported to be worried (36%) about the ADE. Patients perceived the ADE as a chronic problem (91%), and the majority believed more in the ability of the health care provider to control the ADE (61%) than in their own ability (46%). Demographic and clinical variables had a limited contribution to the explained variance of ADE perceptions after adjusting for ADE characteristics, such as perceived severity. Conclusion: Patients with HF perceive particular negative consequences and emotional distress of symptomatic ADE. Open communication between patients and providers with attention for patients ADE perceptions would be valuable during the decision process of ADE management and may result in a regimen aligned with patients' preferences and needs.

show abstract

Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Perceived Adverse Drug Events in Heart Failure

Smedt

Haaijer‐Ruskamp

Groenier

et al. 2011

Journal of Cardiovascular Nursing

Self Cite

View full text Add to dashboard Cite

show abstract

“…In a study in elderly patients, doctors failed to record ADRs even when these were recognised by the patients 28. A failure to correctly attribute clinical presentations to ADRs can lead to unnecessary patient suffering and harms,29 30 and even more symptom-specific medications being prescribed in a prescribing cascade.…”

Section: Discussionmentioning

confidence: 99%

Analysis of drug interactions at the end of life

Morgan

Rowett

Currow

2015

BMJ Support Palliat Care

View full text Add to dashboard Cite

Potential drug-drug interactions are common for this group of patients. Some interactions may be recognised as an acceptable risk when the prescription is written. Further research is necessary to determine the best way to improve recognition of potential drug-drug interactions and the rates of morbidity or accelerated mortality associated with this. It is likely that palliative care services will need to implement multiple strategies including greater use of computerised prescribing software, and greater closer liaison with clinical pharmacists.

show abstract

“…113 Patients with idiopathic DCM have a lower total mortality rate than patients with other types of DCM. 114 However, GDMT is beneficial in all forms of DCM. 78,109,[115][116][117] …”

Section: Epidemiology and Natural History Of Dcmmentioning

confidence: 99%