The impact of periconceptional alcohol exposure on fat preference and gene expression in the mesolimbic reward pathway in adult rat offspring

Dorey, Emily S.; Cullen, Carlie L.; Lucia, D.; Mah, Kunie; Manchadi, M-L Roy; Mühlhäusler, Beverly S.

doi:10.1017/s2040174417000824

Cited by 15 publications

(23 citation statements)

References 33 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was particularly evident in the second choice period, when the novelty of the new diet had presumably waned (Dorey et al . ). This was contrary to a recent study in rat offspring exposed to a higher dose of alcohol exclusively around conception, which found that males preferentially consumed more HFD than controls (Dorey et al .…”

Section: Discussionmentioning

confidence: 97%

“…This was contrary to a recent study in rat offspring exposed to a higher dose of alcohol exclusively around conception, which found that males preferentially consumed more HFD than controls (Dorey et al . ). However, this study was conducted in much older rats (15 months of age).…”

Section: Discussionmentioning

confidence: 97%

“…Food preference was assessed in offspring 4–5 months of age as previously reported (Dorey et al . ). Briefly, one male and one female from each litter were randomly chosen and housed individually in cages with a divided feed hopper.…”

Section: Methodsmentioning

confidence: 97%

“…The test period was split into CP1 and CP2, as a previous study has shown that the novelty of the HFD diminishes over the test period, resulting in different eating behaviour over the 4 day period (Dorey et al . ).…”

Section: Methodsmentioning

confidence: 97%

“…; Dorey et al . ) and children with fetal alcohol spectrum disorder (FASD) (Werts et al . ; Amos‐Kroohs et al .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Prenatal alcohol exposure programmes offspring disease: insulin resistance in adult males in a rat model of acute exposure

Nguyen

Steane

Moritz

et al. 2019

The Journal of Physiology

View full text Add to dashboard Cite

Key points Prenatal alcohol exposure has the potential to affect fetal development and programme chronic disease in offspring. Previous preclinical models typically use high, chronic doses of alcohol throughout pregnancy to examine effects on offspring, particularly on the brain and behaviour. In this study we use a rat model of moderate, acute, prenatal alcohol exposure to determine if this can be detrimental to maintenance of glucose homeostasis in adolescent and adult offspring. Although female offspring were relatively unaffected, there was evidence of insulin resistance in 6‐month‐old male offspring exposed to prenatal alcohol, suggestive of a pre‐diabetic state. This result suggests that even a relatively low‐dose, acute exposure to alcohol during pregnancy can still programme metabolic dysfunction in a sex‐specific manner. Abstract Alcohol consumption is highly prevalent amongst women of reproductive age. Given that approximately 50% of pregnancies are unplanned, alcohol has the potential to affect fetal development and programme chronic disease in offspring. We examined the effect of an acute but moderate prenatal alcohol exposure (PAE) on glucose metabolism, lipid levels and dietary preference in adolescent and/or adult rat offspring. Pregnant Sprague–Dawley rats received an oral gavage of ethanol (1 g kg−1 maternal body weight, n = 9 dams) or an equivalent volume of saline (control, n = 8 dams) at embryonic days 13.5 and 14.5. PAE resulted in a blood alcohol concentration of 0.05–0.06% 1 h post‐gavage in dams. Fasting blood glucose concentration was not affected by PAE in offspring at any age, nor were blood glucose levels during a glucose tolerance test (GTT) in 6‐month‐old offspring (P > 0.5). However, there was evidence of insulin resistance in PAE male offspring at 6 months of age, with significantly elevated fasting plasma insulin (P = 0.001), a tendency for increased first phase insulin secretion during the GTT and impaired glucose clearance following an insulin challenge (P = 0.007). This was accompanied by modest alterations in protein kinase B (AKT) signalling in adipose tissue. PAE also resulted in reduced calorie consumption by offspring compared to controls (P = 0.04). These data suggest that a relatively low‐level, acute PAE programmes metabolic dysfunction in offspring in a sex‐specific manner. These results highlight that alcohol consumption during pregnancy has the potential to affect the long‐term health of offspring.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 97%

“…; Dorey et al . ) and children with fetal alcohol spectrum disorder (FASD) (Werts et al . ; Amos‐Kroohs et al .…”

Section: Introductionmentioning

confidence: 99%