The Impact of Perioperative Antibiotic Prophylaxis on Weight Loss Following Laparoscopic Sleeve Gastrectomy

Jacobson, Richard A.; Terranella, Samantha; Booker, Connor; Khalid, Syed I.; Torquati, Alfonso; Omotosho, Philip

doi:10.1089/lap.2020.0449

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…Indeed, Jacobson et al suggested a role for antibiotic-induced dysbiosis in weight loss after SG. In their study, in a 12-month follow-up, weight loss after SG significantly varied according to the type of preoperative antibiotic prophylaxis treatment received (cefoxitin vs. levofloxacin and metronidazole) [112].…”

Section: Gut Microbiota Manipulation Complementary To Bariatric Surgerymentioning

confidence: 98%

Shifts in gut microbiota and their metabolites induced by bariatric surgery. Impact of factors shaping gut microbiota on bariatric surgery outcomes

Gutiérrez-Repiso

Moreno-Indias

Tinahones

2021

Rev Endocr Metab Disord

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Evidence suggests that bariatric surgery alters gut microbiota, although its impact at compositional and functional level is not well described. In this review, the most relevant findings, mainly described in Roux-en-Y gastric bypass and sleeve gastrectomy, are outlined. Although the number of studies has increased in the last years, conclusive assertions cannot be elaborated. An issue to address is to know the influence of these alterations on host metabolism and the contribution of gut microbiota derived metabolites. New lines of research have been focusing on analysing gut microbiota functionality rather than evaluating changes at compositional level, and the functions of gut microbiota metabolites in host metabolism, what will bring more relevant information about the influence of gut microbiota in bariatric surgery outcomes. Personalized medicine, because of the predictive value of gut microbiota, is another promising field. The possibility of a specific gut microbiota pattern that could predict type 2 diabetes remission or weight loss failure after bariatric surgery is a matter of great interest. However, little is known about how gut microbiota manipulation could contribute to the beneficial effects of bariatric surgery. Peri-operative antibiotics prophylaxis or probiotic supplementation early after surgery, are strategies barely studied so far, and could constitute a novel tool in the management of weight loss and metabolic profile improvement after surgery.

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Section: Gut Microbiota Manipulation Complementary To Bariatric Surgerymentioning

confidence: 98%

Shifts in gut microbiota and their metabolites induced by bariatric surgery. Impact of factors shaping gut microbiota on bariatric surgery outcomes

Gutiérrez-Repiso

Moreno-Indias

Tinahones

2021

Rev Endocr Metab Disord

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“…As in previous studies, it has been found that antibiotics can destroy the intestinal flora; the negative impact of weight loss and the influence has nothing to do with the food intake, sports activities, or energy consumption [ 9 – 12 ]. Also, in a retrospective study [ 5 , 6 ], it was found that patients treated with levofloxacin/metronidazole had significantly less weight loss than patients treated with cefoxitin 6 months after surgery, and this trend continued 12 months after surgery. However, in this clinical study, only the types of antibiotics are grouped, and there is no blank control group, so we can only speculate that the types of antibiotics will have different effects on body weight.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it can avoid excessive consumption of medical resources. But some scholars at home and abroad think sleeve shape after gastrectomy antimicrobial drug use will exist for weight loss [ 5 , 6 ]. Therefore, this article intends to explore the laparoscopic sleeve shape in gastric resection of antimicrobial drug use effect on the patient's body weight changes and inflammatory indexes, providing reference for clinical use antimicrobial drugs.…”

Section: Introductionmentioning

confidence: 99%

Effects of Antibiotics on Weight in Obese Patients after Sleeve Gastrectomy

Hou

Zhai

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Obese patients can significantly reduce weight and have a positive impact on obesity-related diseases. However, the risk of infection complications in obese people is higher than that in normal people, especially the surgical site infection. This research investigates the effect of antibiotics on weight change of obese patients after laparoscopic sleeve gastrectomy (LSG). A retrospective analysis was performed on 131 morbidly obese patients or obese patients with complications who received LSG treatment in the Third Hospital of Shanxi Medical University from 2013 to 2020. Patients were separated into the antibiotic group (59 cases) and the normal group (72 cases) according to whether antibiotics were used after surgery. The differences of postoperative weight-related indexes, inflammation-related indexes, and short-term complications were compared between the two groups. At 12-month follow-up, the % excess weight loss (%EWL) in the antibiotic group was statistically abated than that in the normal group ( 92.99 ± 28.60 , P < 0.01 ). In addition, the percentage of total weight loss (%total weight loss (%TWL)) was abated in the antibiotic group than in the normal group, but it was not significant ( P > 0.05 ). White blood cell count and neutrophil count in the antibiotic group were statistically raised than those in the in normal group ( P < 0.05 ), but neutrophil/lymphocyte ratio (NLR) showed no significant difference. Comparison of short-term postoperative complications between the two groups showed that the number of abdominal wall wound infection, body temperature > 38 ° C , and abdominal pain > 3 days in the antibiotic group were abated, but they were not statistically significant ( P > 0.05 ). Short-term antibiotic exposure after sleeve gastrectomy had an adverse effect on postoperative weight loss, with no significant improvement in short-term complications.

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“…Após gastrectomia laparoscópica de manga, foi demonstrado uma perda de peso significativamente menor dos pacientes que receberam profilaxia perioperatória alternativa (levofloxacina e metronidazol), comparando com os que receberam a profilaxia padrão (cefoxitina). Isso ocorre devido a disbiose ocasionada por alguns medicamentos, refletindo no metabolismo gastrointestinal (Jacobson et al, 2020).…”

Section: Mudanças Fisiológicas Da Microbiota Gastrointestinal Pós-cir...unclassified

Readaptação à nova fisiologia do paciente submetido à cirurgia bariátrica

Aragão,

Melo,

Rêgo

et al. 2023

RSD

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A cirurgia bariátrica é o procedimento indicado para o tratamento da obesidade, visando a melhora na qualidade de vida do paciente submetido à mencionada intervenção, quando alternativas clínicas não são bem-sucedidas. Esta cirurgia causa diversas mudanças na fisiologia do ser humano, principalmente gastrointestinal, e, devido a isso, têm critérios rigorosos de indicação para ser realizada. A presente revisão objetivou entender as mudanças fisiológicas, com enfoque na remissão de doenças crônicas e alterações na microbiota, além de identificar os principais indicativos para realização do procedimento. Foi realizado um levantamento bibliográfico nas bases de dados PubMed e Scielo, através de uma revisão sistemática de literatura, de publicações do ano de 2017 ao ano de 2022, nos idiomas português, inglês e espanhol. A partir disso, a cirurgia bariátrica promove mudanças fisiológicas importantes no paciente após o procedimento, tanto no aspecto de doenças crônicas quanto da microbiota gastrointestinal.

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The Impact of Perioperative Antibiotic Prophylaxis on Weight Loss Following Laparoscopic Sleeve Gastrectomy

Cited by 7 publications

References 11 publications

Shifts in gut microbiota and their metabolites induced by bariatric surgery. Impact of factors shaping gut microbiota on bariatric surgery outcomes

Shifts in gut microbiota and their metabolites induced by bariatric surgery. Impact of factors shaping gut microbiota on bariatric surgery outcomes

Effects of Antibiotics on Weight in Obese Patients after Sleeve Gastrectomy

Readaptação à nova fisiologia do paciente submetido à cirurgia bariátrica

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