The impact of physical exercise on cognitive and affective functions and serum levels of brain-derived neurotrophic factor in nursing home residents: A randomized controlled trial

Arrieta, Haritz; Rezola-Pardo, Chloe; Kortajarena, Maider; Hervás, Gotzone; Gil, Javier; Yanguas, José Javier; Iturburu, Miren; Gil, Susana María; Irazusta, Jon; Rodríguez-Larrad, Ana

doi:10.1016/j.maturitas.2019.10.014

Cited by 30 publications

(26 citation statements)

References 27 publications

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“…An RCT of 112 participants by Haritz Arrieta, et al. 36 reported that a 6‐month individualized, progressive, multicomponent physical exercise intervention is effective at maintaining cognitive function. Miu et al.…”

Section: Discussionmentioning

confidence: 99%

The effect of physical activity interventions on cognition function in patients with diabetes: A systematic review and meta‐analysis

Wang

Yan

et al. 2021

Diabetes Metabolism Res

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Background: In recent years, studies have revealed that cognition may be impaired by glucose metabolism disorder. Meanwhile, physical activity has been demonstrated to maintain blood glucose. This meta-analysis was conducted to assess the effect of physical activity on cognition in patients with diabetes and provide evidence for the treatment of cognition impairment among them. Methods:We searched studies published in five databases from 1 January 1984 to 29 August 2020. A random-effect or fixed-effect meta-analysis was used to estimate the pooled effect of physical activity on the change of cognition throughout intervention duration and post-intervention cognition scores by standardized mean difference (SMD) and its 95% confidence interval (CI). We used funnel plots to evaluate the publication bias, I 2 statistic to evaluate the heterogeneity and did subgroup analysis stratified by sample size and follow-up time.Results: Five eligible studies involving 2581 patients with diabetes were included. The pooled effect of physical activity on cognition improvement in patients with diabetes was significant (SMD = 0.98, 95% CI: 0.34-1.62), while the effect on post-intervention cognition scores was not significant (SMD = 0.35, 95% CI: −0.04-0.73). In the subgroup analysis, the pooled effect was significantly higher in studies of follow-up time less than 1 year (SMD = 2.14, 95% CI: 1.63-2.64), while observing no significant effect in studies of follow-up time over 1 year (SMD = 0.10, 95% CI: −0.11-0.32).Conclusions: Physical activity is beneficial to improving cognition in patients with diabetes. However, the long-term effect needs to be explored in future studies. K E Y W O R D S cognition, diabetes mellitus, meta-analysis, physical activity # Contributed equally.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

The effect of physical activity interventions on cognition function in patients with diabetes: A systematic review and meta‐analysis

Wang

Yan

et al. 2021

Diabetes Metabolism Res

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“…10 Contudo, grande parte dos estudos se concentraram principalmente em idosos da comunidade, 11 e a maioria deles utilizaram treinamentos multicomponentes compostos por exercícios aeróbicos, respiratórios ou de fortalecimento global, portanto não avaliaram especificamente os efeitos de um programa de fortalecimento muscular de membros inferiores. 12 Considerando-se que o fisioterapeuta nas instituições de longa permanência para idosos (ILPI) tem o foco de restaurar e manter a funcionalidade dos mesmos, 13 este estudo se justifica pela importância em determinar intervenções ideais para exercícios físicos necessárias para promover melhorias significativas no equilíbrio, performance funcional e força muscular de idosos institucionalizados. 14…”

Section: Introductionunclassified

Impacto de um programa de fortalecimento muscular dos membros inferiores no equilíbrio e na performance funcional de idosos institucionalizados: um estudo controlado e randomizado

et al. 2020

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A performance funcional é maximizada através de programas de fortalecimento muscular em idosos. Contudo, poucas intervenções foram implementadas em idosos institucionalizados para avaliar os efeitos de programas de exercícios de fortalecimento muscular em desfechos como o equilíbrio, performance funcional e força muscular. Objetivo: Avaliar o impacto de um programa de fortalecimento muscular de membros inferiores no equilíbrio, performance funcional e força muscular de idosos institucionalizados. Métodos: Ensaio clínico controlado e randomizado. O equilíbrio, a performance funcional e a força muscular foram avaliados através da Escala de Equilíbrio de Berg (EEB), Marcha Tandem (MT), Short Physical Performance Battery (SPPB) e Teste do Esfigmomanômetro (TE), respectivamente. O grupo experimental (GE, n=11) participou do programa de exercícios em grupo, três vezes semanais, durante oito semanas, enquanto o grupo controle (GC, n=8) continuou sua rotina habitual. Foram calculados os intervalos de 95% de confiança para as diferenças entre os grupos experimental e controle (experimental – controle) e entre os dois momentos de observação (pós – pré). Foi realizada análise de intenção de tratar. Resultados: O GE apresentou um ganho significativo em relação ao GC para a EEB (DM=3,7 IC95% 1,0 a 6,5), MT DM=3,5 IC95% 0,7 a 6,2), FMEJ (DM=33,2 IC95% 4,9 a 61,5) e FMD (DM=37,5 IC95% 9,6 a 65,3). Conclusão: O programa de fortalecimento muscular foi capaz de melhorar o equilíbrio, a performance funcional e a força muscular em idosos institucionalizados.

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“…The association between multicomponent physical exercise (a composite strength and balance training program associated with a walking recommendation) and brain-derived neurotrophic factor (BDNF), a factor that promotes the growth and differentiation of neurons and supports the survival of existing neurons, was previously explored. It seems that blood levels of BDNF are not affected by the multicomponent physical exercise intervention 35 . This result is consistent with animal models in which strength exercise reduces aerobic exercise-induced adult hippocampal neurogenesis due to reduced BDNF and β-hydroxybutyrate 36 , and with a study in young male participants that showed no effect of acute strength exercise on plasma levels of BDNF 37 .…”

Section: Discussionmentioning

confidence: 98%

Effect of multicomponent exercise in cognitive impairment: A systematic review and meta-analysis

Cavero‐Redondo

Venegas-Sanabria

Martínez‐Vizcaíno

et al. 2022

Preprint

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Background: Multicomponent physical exercise is the most recommended type of physical intervention in older adults, however, this effect on cognition is unclear. This study assesses the effect of multicomponent physical exercise on global cognition in people with mild cognitive impairment or dementia.Methods: Randomized controlled trials published until January 2021 were searched across three electronic databases (PubMed, Scopus, and Cochrane Database). Data about exercises included in the multicomponent intervention (endurance, strength, balance, or flexibility), the inclusion of aerobic exercise, and the change in global cognition were extracted. The effect size was represented as a standardized mean difference. Risk of bias was assessed by the RoB2 tool. Results: A total of 8 studies were included. The overall effect size suggested an effect of multicomponent exercise on global cognition. However, the subgroup analysis showed an effect only when aerobic exercise was included in the intervention. No effect when mild cognitive impairment and dementia were assessed separately was found.Conclusion: This study suggests that multicomponent physical exercise could have an effect on global cognition in people with mild cognitive impairment or dementia only when aerobic exercise is included in the intervention. Our results support the inclusion of structured physical exercise programs in the management of people with cognitive impairment.

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The impact of physical exercise on cognitive and affective functions and serum levels of brain-derived neurotrophic factor in nursing home residents: A randomized controlled trial

Cited by 30 publications

References 27 publications

The effect of physical activity interventions on cognition function in patients with diabetes: A systematic review and meta‐analysis

The effect of physical activity interventions on cognition function in patients with diabetes: A systematic review and meta‐analysis

Impacto de um programa de fortalecimento muscular dos membros inferiores no equilíbrio e na performance funcional de idosos institucionalizados: um estudo controlado e randomizado

Effect of multicomponent exercise in cognitive impairment: A systematic review and meta-analysis

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