The impact of plaque type on strut embedment/protrusion and shear stress distribution in bioresorbable scaffold

Torii, Ryo; Tenekecioğlu, Erhan; Katagiri, Yuki; Chichareon, Ply; Sotomi, Yohei; Dijkstra, Jouke; Asano, Taku; Modolo, Rodrigo; Takahashi, Kuniaki; Jonker, Hans; Geuns, Robert van; Onuma, Yoshinobu; Pekkan, Kerem; Bourantas, Christos V.; Serruys, Patrick W.

doi:10.1093/ehjci/jez155

Cited by 6 publications

(5 citation statements)

References 39 publications

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“…EROSION Study (Effective Anti-Thrombotic Therapy Without Stenting: Intravascular Optical Coherence Tomography-Based Management in Plaque Erosion) [47] was the first study to suggest that patient with acute coronary syndrome due to plaque erosion can be managed by effective antiplatelet therapy without stent implantation. Torii et al reported the impact of plaque type on stent strut [48]. However, high price and technical safety concerns restrict the application of OCT to a selected population of AMI, surrogates for predicting culprit lesions are needed in clinical practice.…”

Section: A/c As a Predictor For Plaque Vulnerability Inmentioning

confidence: 99%

Association between Admission Hyperglycemia and Culprit Lesion Characteristics in Nondiabetic Patients with Acute Myocardial Infarction: An Intravascular Optical Coherence Tomography Study

Zhou

Sheng

Liu

et al. 2020

Journal of Diabetes Research

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Background. Hyperglycemia is frequently observed in acute myocardial infarction (AMI). Diabetes mellitus (DM) patients and non-DM patients have different culprit lesion phenotypes and few data are available on non-DM patients with admission hyperglycemia. Therefore, we aimed to investigate the association between admission hyperglycemia and culprit lesion characteristics using optical coherence tomography (OCT) in AMI patients. Methods and Results. We consecutively enrolled 434 patients with AMI, and 277 patients were included in analysis: 65.7% (n=182) non-DM patients and 34.3% (n=95) DM patients. We measured acute blood glucose (ABG) and hemoglobin A1c to calculate the acute-to-chronic glycemic ratio (A/C). Then, we grouped non-DM patients into tertiles of A/C. OCT-based culprit lesion characteristics were compared across A/C tertiles in non-DM patients and between DM and non-DM patients. Non-DM patients had fewer lipid-rich plaques (52.7% versus 68.4%, p=0.012) and thin-cap fibroatheroma (TCFA) (19.8% versus 34.7%, p=0.006) than DM patients but similar prevalence of plaque rupture (47.3% versus 56.8%, p=0.130). Non-DM patients with the highest A/C tertile had the highest prevalence of plaque rupture (pfor trend=0.002), lipid-rich plaque (pfor trend=0.001), and TCFA (pfor trend=0.003). A/C>1.22 but not ABG>140 mg/dl predicted a high prevalence of plaque rupture, lipid-rich plaque, and TCFA in non-DM patients. Conclusions. In AMI patients without DM, admission hyperglycemia is associated with vulnerable culprit lesion characteristics, and A/C is a better predictor for vulnerable culprit plaque characteristics than ABG. These results call for a tailored evaluation and management of glucose metabolism in nondiabetic AMI patients. This trial is registered with NCT03593928.

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Section: A/c As a Predictor For Plaque Vulnerability Inmentioning

confidence: 99%

Association between Admission Hyperglycemia and Culprit Lesion Characteristics in Nondiabetic Patients with Acute Myocardial Infarction: An Intravascular Optical Coherence Tomography Study

Zhou

Sheng

Liu

et al. 2020

Journal of Diabetes Research

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“…On the other hand, in acute coronary syndromes -a population that was underrepresented in the first stent studies -the calcific burden in culprit lesions is higher in males 11 . Plaque composition, especially an increased calcific burden, is a well-known predictor of TLR in metallic stents 12 and is expected also to have prognostic implications in Absorb BVS, as the acute gain is smaller following implantation of this device 13 that also has thicker struts which, in case of a fibrotic or calcific plaque, tend to protrude into the lumen, causing flow disturbances and a higher shear rate that predisposes to platelet activation and thrombus formation 14 . The differences in plaque composition between male and female patients may explain the numerically lower scaffold thrombosis rate noted in female patients in this study but also in the AIDA study in which 53.6% of the recruited patients were admitted with an acute coronary syndrome (Figure 1) 15 .…”

Section: Article See Page 615mentioning

confidence: 99%

Sex differences in clinical outcomes following bioresorbable scaffold implantation: a paradigm shift?

Bourantas

Bajaj²,

Tufaro³

et al. 2019

EuroIntervention

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“…There are several factors that can potentially influence endothelium recovery post stenting, including stent deployment depth, the scale of endothelial denudation, hemodynamic changes, and the structure and material properties of the stent (Kakinoki et al, 2018;Wang et al, 2018;Torii et al, 2020). Due to differences in individual vessel diameter and atherosclerotic plaque type, stent placement causes endothelium injury of various depths and scales (O'Brien et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…The presence of stent markedly alters vascular mechanics, especially blood flow patterns and fluid shear stress (FSS) (Gijsen et al, 2019;Torii et al, 2020). Under physiological conditions, endothelial cells are exposed to laminar FSS ranging from 10 to 20 dyn/cm 2 (Kwak et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

The Combined Contribution of Vascular Endothelial Cell Migration and Adhesion to Stent Re-endothelialization

Wang

Fang

et al. 2021

Front. Cell Dev. Biol.

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Coronary stent placement inevitably causes mechanical damage to the endothelium, leading to endothelial denudation and in-stent restenosis (ISR). Re-endothelialization depends mainly on the migration of vascular endothelial cells (VECs) adjacent to the damaged intima, as well as the mobilization and adhesion of circulating VECs. To evaluate the combined contribution of VEC migration and adhesion to re-endothelialization under flow and the influence of stent, in vitro models were constructed to simulate various endothelial denudation scales (2 mm/5 mm/10 mm) and stent deployment depths (flat/groove/bulge). Our results showed that (1) in 2 mm flat/groove/bulge models, both VEC migration and adhesion combined completed the percentage of endothelial recovery about 27, 16, and 12%, and migration accounted for about 21, 15, and 7%, respectively. It was suggested that the flat and groove models were in favor of VEC migration. (2) With the augmentation of the injury scales (5 and 10 mm), the contribution of circulating VEC adhesion on endothelial repair increased. Taken together, endothelial restoration mainly depended on the migration of adjacent VECs when the injury scale was 2 mm. The adhered cells contributed to re-endothelialization in an injury scale-dependent way. This study is helpful to provide new enlightenment for surface modification of cardiovascular implants.

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The impact of plaque type on strut embedment/protrusion and shear stress distribution in bioresorbable scaffold

Cited by 6 publications

References 39 publications

Association between Admission Hyperglycemia and Culprit Lesion Characteristics in Nondiabetic Patients with Acute Myocardial Infarction: An Intravascular Optical Coherence Tomography Study

Association between Admission Hyperglycemia and Culprit Lesion Characteristics in Nondiabetic Patients with Acute Myocardial Infarction: An Intravascular Optical Coherence Tomography Study

Sex differences in clinical outcomes following bioresorbable scaffold implantation: a paradigm shift?

The Combined Contribution of Vascular Endothelial Cell Migration and Adhesion to Stent Re-endothelialization

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